DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl18 and Ece1

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001356106.1	Gene:	Ece1 / 230857	MGIID:	1101357	Length:	769	Species:	Mus musculus

Alignment Length:	705	Identity:	194/705 - (27%)
Similarity:	300/705 - (42%)	Gaps:	125/705 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 MKPEVSPCDDFYTHACGNWHRHNPAQLLGDVMTDNFKLISKGFDRRLQRLL-RANDLQSELEKKM 117
            |.|.|.||.||:::|||.|.:.||.. .|......|..:.:.....::.|| .|....||.|:|.
Mouse   114 MDPTVDPCQDFFSYACGGWIKANPVP-DGHSRWGTFSNLWEHNQAVIKHLLENATASVSEAERKA 177

  Fly   118 QRFYMSC-NLVHRDDVHYKLALENVIREYG----TLPALVGAQWNSSDFSWWRTVAQIQHKYGKQ 177
            |.:|.:| |....:::..|..:| :|.:.|    |.|      |...:|.  .|:..:...|...
Mouse   178 QVYYRACMNETRIEELRAKPLME-LIEKLGGWNITGP------WAKDNFQ--DTLQVVTAHYRTS 233

  Fly   178 IIIGLEIMHDIRNTSVNRV--------------YISQPDFKTINTRLTNLM------------EE 216
            ....:.:..|.:|::.|.:              |:::.:.:.:.|...|.|            :.
Mouse   234 PFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDA 298

  Fly   217 VRTSMDLQQYFGLSSSVAKHTAEQLTELERTFSSGGSGAATLQESLSLY--TVADLQEKYSDHLN 279
            :|..|  ||.....:::|..|..|  |..|            .|.|..:  |.|:|| ..:..:|
Mouse   299 IRPQM--QQILDFETALANITIPQ--EKRR------------DEELIYHKVTAAELQ-TLAPAIN 346

  Fly   280 FTEFLGLIL--GEENIPKSLYIYDEEYLDKALLTMRSTPLATQANYVLWKL-------LEDFLVD 335
            :..||..|.  .|.|..:.:.:||:|||.:....:.:|......||::|.|       |:....|
Mouse   347 WLPFLNTIFYPVEINESEPIVVYDKEYLRQVSTLINNTDKCLLNNYMMWNLVRKTSSFLDQRFQD 411

  Fly   336 AQPKDMV-------------KWCTESTKKYFGKLAEHAVYKRYRNPDVESEVHKIWDQIKGIFRQ 387
            |..|.|.             |:|...|:...|........|.....|.::...:|..:||..|.:
Mouse   412 ADEKFMEVMYGTKKTCIPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIIMEIKKAFEE 476

  Fly   388 RLLGDKLDWISNATRTLAIEKLERMHLNINSY-----DEENFENVYGEVFIDRLNYVSNVQQLLI 447
            .|  ..|.|:...||..|.||.:.:: |:..|     |.:..:.|:        |..:.|..|..
Mouse   477 SL--STLKWMDEETRRSAKEKADAIY-NMIGYPNFIMDPKELDKVF--------NDYTAVPDLYF 530

  Fly   448 AKGIRFVA---RINQPADSVDAT---ELLGFTPA-----YNIQENNITIPVALLQPRYFWGDQYP 501
            ...:||..   |:.  ||.:...   :....||.     |:..:|.|..|..:||.. |:....|
Mouse   531 ENAMRFFNFSWRVT--ADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAP-FYTRSSP 592

  Fly   502 EALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSK 566
            .||.:..:|.::.||:.|.|||.||:||..|||.|||...|...|:::.:|...||..|...|..
Mouse   593 NALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYSNYSVNGEP 657

  Fly   567 LPESKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQ 631
            :.......|||||:||||.||.||:.|:.:...|    :|:..|...|.||||||:||:.|.
Mouse   658 VNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAE----QTLPTLGLTSNQLFFLGFAQVWCS--- 715

  Fly   632 FLFQPWVSQ----SDRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
             :..|..|.    :|.|:||::||||.|||.:||...|.|...:||:|.:||.::
Mouse   716 -VRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPHHKCEVW 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	194/703 (28%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	190/696 (27%)
Ece1	NP_001356106.1	M13	118..767	CDD:341056	191/697 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841072
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850