DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl18 and ECE1

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens

Alignment Length:	704	Identity:	193/704 - (27%)
Similarity:	299/704 - (42%)	Gaps:	123/704 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 MKPEVSPCDDFYTHACGNWHRHNPAQLLGDVMTDNFKLISKGFDRRLQRLLRANDLQ-SELEKKM 117
            |.|.|.||.||:::|||.|.:.||.. .|......|..:.:.....::.||..:... ||.|:|.
Human   123 MDPTVDPCHDFFSYACGGWIKANPVP-DGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKA 186

  Fly   118 QRFYMSC-NLVHRDDVHYKLALENVIREYG---TLPALVGAQWNSSDFSWWRTVAQIQHKYGKQI 178
            |.:|.:| |....:::..|..:|.:.|..|   |.|      |...:|.  .|:..:...|....
Human   187 QVYYRACMNETRIEELRAKPLMELIERLGGWNITGP------WAKDNFQ--DTLQVVTAHYRTSP 243

  Fly   179 IIGLEIMHDIRNTSVNRV--------------YISQPDFKTINTRLTNLM------------EEV 217
            ...:.:..|.:|::.|.:              |:::.:.:.:.|...|.|            |.:
Human   244 FFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI 308

  Fly   218 RTSMDLQQYFGLSSSVAKHTAEQLTELERTFSSGGSGAATLQESLSLY--TVADLQEKYSDHLNF 280
            |..|  ||.....:::|..|..|  |..|            .|.|..:  |.|:|| ..:..:|:
Human   309 RPQM--QQILDFETALANITIPQ--EKRR------------DEELIYHKVTAAELQ-TLAPAINW 356

  Fly   281 TEFLGLIL--GEENIPKSLYIYDEEYLDKALLTMRSTPLATQANYVLWKL-------LEDFLVDA 336
            ..||..|.  .|.|..:.:.:||:|||::....:.:|......||::|.|       |:....||
Human   357 LPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDA 421

  Fly   337 QPKDMV-------------KWCTESTKKYFGKLAEHAVYKRYRNPDVESEVHKIWDQIKGIFRQR 388
            ..|.|.             |:|...|:...|........|.....|.:|...:|..:||..|.:.
Human   422 DEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEES 486

  Fly   389 LLGDKLDWISNATRTLAIEKLERMHLNINSY-----DEENFENVYGEVFIDRLNYVSNVQQLLIA 448
            |  ..|.|:...||..|.||.:.:: |:..|     |.:..:.|:        |..:.|..|...
Human   487 L--STLKWMDEETRKSAKEKADAIY-NMIGYPNFIMDPKELDKVF--------NDYTAVPDLYFE 540

  Fly   449 KGIRFVA---RINQPADSVDAT---ELLGFTPA-----YNIQENNITIPVALLQPRYFWGDQYPE 502
            ..:||..   |:.  ||.:...   :....||.     |:..:|.|..|..:||.. |:....|:
Human   541 NAMRFFNFSWRVT--ADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAP-FYTRSSPK 602

  Fly   503 ALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSKL 567
            ||.:..:|.::.||:.|.|||.||:||..|||.|||...|...|:.:.:|...||..|...|..:
Human   603 ALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPV 667

  Fly   568 PESKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQF 632
            .......|||||:||||.||.||:.|:.:...|    .::..|...:.||||||:||:.|.
Human   668 NGRHTLGENIADNGGLKAAYRAYQNWVKKNGAE----HSLPTLGLTNNQLFFLGFAQVWCS---- 724

  Fly   633 LFQPWVSQ----SDRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
            :..|..|.    :|.|:||::||||.|||.:||...|.|...:||:|.:||.::
Human   725 VRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	193/702 (27%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	189/695 (27%)
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	188/693 (27%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	190/696 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150956
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850