DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and nep-18

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_494297.1	Gene:	nep-18 / 186911	WormBaseID:	WBGene00019343	Length:	701	Species:	Caenorhabditis elegans

Alignment Length:	776	Identity:	178/776 - (22%)
Similarity:	296/776 - (38%)	Gaps:	177/776 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LWLCLLVAIVPAMAKPSDAGDPFADDLTSDYAKKIIVQAKVAEMKTMMKPEVSPCDDFYTHACGN 71
            |.:.|..::.|:.:..:..|.|     .:.::|:.:  ..:|.:|......|.||:||:.|.||.
Worm     3 LMIALWASLWPSGSSNAPNGSP-----ETCWSKECV--GVLAMIKNYQNASVDPCEDFFEHTCGR 60

  Fly    72 WHRHNPAQLLGDVMTDNFKLISKGFDRRLQRLL-------RANDLQSELEKKMQRFYMSC-NLVH 128
            :..|        ||.||    |.|:.:..|.|.       :.|...|:..::::.|..|| :...
Worm    61 YSEH--------VMDDN----SWGYVQYKQLLYQVFAIARKTNKFNSKPNEQLRIFTKSCLDRKE 113

  Fly   129 RDDVHYKLALENVIREYGTLPALVGAQWNSSDFSWWRTVAQIQHKY-----GKQIIIGLEIMHDI 188
            .|:..:: .|.|.|.|.|..| ::...||...|.    ::.:..||     .:...:.:|....|
Worm   114 MDEDTFQ-DLRNDIEERGGFP-MIDPNWNEEKFD----LSDMLAKYLSINRNRMGFLSVEPYAAI 172

  Fly   189 R-NTSVNRVYISQPDFKTINTRLTNLMEEVRTSMDLQQYFGLSSSVAKHTA-----EQLTELERT 247
            . |.||||:|:|.......|..:...:.:...:..|::...|.:.....|.     .:|.:||..
Worm   173 EGNKSVNRLYVSPGPHWVYNWAMGISIYKDSVAFMLRRLLKLENRELNETIYDKEFAELVQLEAN 237

  Fly   248 FSSGGSGAATLQESLSLYTVADLQ------EKYSDHLNFTEFLGLI----------------LGE 290
            ||                |:||.:      :..|...|.|:.:.:|                ..|
Worm   238 FS----------------TLADYRNLALDNDNMSKSRNLTDLVKMIPEIDWIKILKALARHGTSE 286

  Fly   291 ENIPKSL----------YIYDEEYLDKALLTMRSTPLATQANYVLWKLLED----FLVDAQPK-- 339
            |:..|.|          |.:.|......:.|  .||.:..|||::.:.|.|    |....||:
Worm   287 EDEEKLLERVTVHGAGEYFFGENRELARIAT--ETPKSALANYLVVRQLIDVALYFYDKDQPRQN 349

  Fly   340 ------DMVKWCTESTKKYF-----GKLAEHAVYKRYRNPDVESEVHKIWDQIKGIFRQRLLGDK 393
                  |...:|......:|     ....|.:.:|......:|....||..:.:.||.:.
Worm   350 KFYNHVDQQSFCATQVASFFPMPSMNVFIESSQFKIENLKVIEEMFVKIKAEYEQIFTEN----- 409

  Fly   394 LDWISNATRTLAIEK-------------------LERMHLNINSYDEENFENVY-------GEVF 432
             :::....|...|.|                   ||:|:..:|..|.::...||       .|..
Worm   410 -EYLELEIREFLIRKLNAIDGKFGLDQYTEGKPLLEKMYETLNFLDTDSPWQVYMKMWRHWSEQL 473

  Fly   433 IDRLNYVSNVQQLLIAKGIRFVARINQPADSVDATELLGFTPAYNIQENNITIPVALLQPRYFWG 497
            ::.:.:                   :.|.|.|: .::.|...||....|:..|.:..|  .|.|.
Worm   474 VEHIVH-------------------DTPLDPVN-LKMFGTHAAYQPYPNHFYINLPYL--TYPWM 516

  Fly   498 D-QYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLK---SRYEFEERRKCFQAQYH 558
            | .:|....|..|||::.||:.|.||...|:.|.||....:|..:   |..|:|.|.||.:.||.
Worm   517 DADFPANTNYGYLGYVIGHEIGHAFDHFHRKLDESGRQQQYWFTETNSSNTEYELREKCLRDQYS 581

  Fly   559 EYQYGGSK--LPESKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQLFFLG 621
            .|:..|..  :..:..:.|...|..|::.|:..:|    :..:|  .|..:.||..:..||||..
Worm   582 AYKEPGYDFFMNGTHCRYEIAGDHMGIRTAFRVFE----KVKKE--DRFRLPGLEMSEEQLFFYN 640

  Fly   622 YAQLLCDDVQFLFQPWVSQSDRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
            ||...||.......|....:.:|..::|||.|.:.|..||...|||.:::||:||.||.:|
Worm   641 YAFRQCDVYNPNKLPRNMLARQHPTNRYRVNGVIQNIPEFAEAFNCPKNSPMNPEMKCKLY 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	169/727 (23%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	167/720 (23%)
nep-18	NP_494297.1	PepO	42..692	CDD:226118	163/719 (23%)
nep-18	NP_494297.1	M13	47..699	CDD:189000	168/721 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28686
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.890