DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl18 and Phex

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_035207.1	Gene:	Phex / 18675	MGIID:	107489	Length:	749	Species:	Mus musculus

Alignment Length:	746	Identity:	180/746 - (24%)
Similarity:	311/746 - (41%)	Gaps:	173/746 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 AEMKTMMKPE---------------VSPCDDFYTHACGNWHRHNPAQLLGDVMTDN-FKLISKGF 96
            |:.:..:|||               |.||::|:..||..|..:||  :..|:.:.. :..:....
Mouse    49 AKQEYCLKPECIEAAAAIMSKVNLSVDPCENFFRFACDGWISNNP--IPEDMPSYGVYPWLRHNV 111

  Fly    97 DRRLQRLL-----RANDLQSELEKKMQRFYMSC---NLVHRDDVHYKLALENVIR----EYGTLP 149
            |.:|:.||     |..|  :|..:|.:..|.||   ..:.:.|..   .|.:::|    .:..|.
Mouse   112 DLKLKALLEKSVSRRRD--TEAVQKAKILYSSCMNEKAIEKADAK---PLLHILRHSPFRWPVLE 171

  Fly   150 ALVGAQ--WNSSDFSWWRTVAQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQPDFKTINTRLTN 212
            |.:|.:  |:...||..:|:|..:.:|...:.|              |:|:| ||.|..|..:..
Mouse   172 ANIGPEGVWSERKFSLLQTLATFRGQYSNSVFI--------------RLYVS-PDDKASNEHILK 221

  Fly   213 LMEEVRTSMDLQQYF-------------------------GLSSSVAKHTAEQLTELE------- 245
            | ::...|:.:::.|                         |.:||.|:|..:.:..||
Mouse   222 L-DQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIM 285

  Fly   246 -----RTFSSGGSGAATLQESLSLYTVADLQEKYSDHLNFTEFLGLILGEENIPKSLY------- 298
                 ||             |.::|...::.| .|..:...::||.|  ::.|...||
Mouse   286 IPHENRT-------------SEAMYNKMNISE-LSAMIPQFDWLGYI--KKVIDTRLYPHLKDIG 334

  Fly   299 ------IYDEEYLDKALLTMRSTPLATQANYVLWKLLEDFLVDAQPKDMVKW------------- 344
                  :...:|.......:.:....|.|||::|:::...:.:...:...:|
Mouse   335 PSENVVVRVPQYFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTL 399

  Fly   345 ------CT---ESTKKY-FGKLAEHAVYKRYRNPDVESEVHKI-WDQIKGIFRQRLLGDKLDWIS 398
                  |.   ||...| .||:..:..::..:...:|..:..: |..|.      :|..:.:|:.
Mouse   400 LPQWDKCVNFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFID------MLEKENEWMD 458

  Fly   399 NATRTLAIEKLERMHLNINSYDEENFENVY-----GEVFIDRLNYVSNVQQL--LIAKGIRFVAR 456
            ..|:..|.||...:...: .|.|....:.|     ..:.....:|..||.|.  .:|:...|..|
Mouse   459 AGTKRKAQEKARAVLAKV-GYPEFIMNDTYVNEDLKAIKFSESDYFGNVLQTRKYLAQSDFFWLR 522

  Fly   457 INQPADS--VDATELLGFTPAYNIQENNITIPVALLQPRYFWGDQYPEALKYATLGYLLAHEMLH 519
            ...|...  .:.|.:..|   |:...|.|..|...||..:|||.:||.:|.|..:|.::.||..|
Mouse   523 KAVPKTEWFTNPTTVNAF---YSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTH 584

  Fly   520 GFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQY--GGSKLPESKDQSENIADSGG 582
            |||::||:||.:|||.|||.::|..:|:|:.||...||..|.:  .|..:...:...|||||:||
Mouse   585 GFDNNGRKYDKNGNLDPWWSVESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGG 649

  Fly   583 LKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQFLFQPWVS----QSDR 643
            |:.|:.||..|:..:.:.| :...:.|:.|.:.|||||.||.:.|:.    ::|..:    |...
Mouse   650 LREAFRAYRKWINDRRQGV-EEPLLPGITFTNNQLFFLSYAHVRCNS----YRPEAAREQVQIGA 709

  Fly   644 HAPSKYRVIGPLSNFQEFPWVFNCSQSAPMD 674
            |:|.::||.|.:|||:||...|||.:::.|:
Mouse   710 HSPPQFRVNGAISNFEEFQKAFNCPRNSTMN 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	179/740 (24%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	176/721 (24%)
Phex	NP_035207.1	PepO	67..741	CDD:226118	176/728 (24%)
Phex	NP_035207.1	M13	74..747	CDD:189000	176/721 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920