Protein Alignment Nepl18 and nep-21

DIOPT Version :10

• Sequence 1: NP_651643.1
• Gene: Nepl18 / 43410
• FlyBaseID: FBgn0039611
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_001360525.1
• Gene: nep-21 / 179925
• WormBaseID: WBGene00011794
• Length: 864
• Species: Caenorhabditis elegans
• Alignment Length: 728
• Identity: 180/728 - (24%)
• Similarity: 308/728 - (42%)
• Gaps: 151/728 - (20%)

  Fly    54 MKPEVSPCDDFYTHACGNW--HRHNPA-QLLGDVMTDNFKLISKGFDRRLQRLLRANDLQSELEK 115
            :..:::||:|||..||||:  :::.|| :.|...::|....::|.....||..:.||  :...:|
 Worm   189 LNSKINPCEDFYEFACGNYGLNKNLPANKPLRHTISDVQSRLNKQVKSMLQSPISAN--EKPWDK 251

  Fly   116 KMQRFYMSCNLVHRDDVHYKL----ALENVIREYGTLPALVGAQWNSSDFSWWRTVAQIQHKYG- 175
            ..:.:|..|    .|:...:.    |:.::.:..|..|.|.|.:|.....||...:|.:.:..|
 Worm   252 VAKGYYQKC----LDEEELESTGVEAMRDIAKRIGGWPTLEGDKWQEWSHSWEEQIALVLNLTGV 312

  Fly   176 KQIIIGLEIMHDIRNTSVNRVYISQPDF-------------KTINTRLTNLMEEVRTSMDLQQYF 227
            ..:|:.:.:.||..|:|.:.:.:.||.:             ..:....|.||:....::
 Worm   313 NAVILEMAVTHDPSNSSRSVIELDQPKWGAGSRYPYLSGANDPMLRNYTTLMKMTAVAL------ 371

  Fly   228 GLSSSVAKHTAEQLTELER---TFSSG---------GSGAATLQESLSLYTVADLQEKYSDHLNF 280
            |...::|:....:..|.|.   .||:.         |:....|.:..|::...:. |||..
 Worm   372 GADPAIAEKEMNEAMEFELKLVNFSADDMVRRDPERGNNRFELWQLKSVFPFINF-EKYLK---- 431

  Fly   281 TEFLGLILGEENIPKSLYIYDEEYLDKALLTMRSTPLATQANYVLWKLLE-----DF-------- 332
            |.|..|:....|  .::.:.:.:|.......::|||....|||:.|:|::     |:
 Worm   432 TVFKELVALSPN--HTVIVREIDYFVGIQHVLQSTPKRVLANYISWRLVQGGPTGDYFSFSPFLP 494

  Fly   333 ----------------LVDAQPKDMVKWCTEST-------------KKYFGKLAEHAVYKRYRNP 368
                            :.::.|.|..:.|...:             :.:|.|  |.|:.|
 Worm   495 PSAREPFYQFKANQTGMFNSPPPDRWEDCVTLSVIMMDMPVGRLFVENFFEK--ERAMKK----- 552

  Fly   369 DVESEVHKIWDQIKGIFRQRLLGDKLDWISNATRTLAIEKLER--------MHLNINSYDEENFE 425
                 :.::...:|..|.::|  ..|||:...||..||.|...        |.|..:::.|:|
 Worm   553 -----MTELTSYLKNEFIKQL--HVLDWMDEITRRRAISKANMIEYKSGFPMVLFNDTWMEKN-- 608

  Fly   426 NVYGEVFIDRLNYVSNVQQLLIAKGIRF---VARINQPAD---------SVDATELLGFTPAYNI 478
              :|.:...| .|:.::  .:..|.:||   :.|::||.|         .|||        .|..
 Worm   609 --WGMIIKPR-EYLLHL--TIRVKLVRFTEELLRLDQPLDRSMWFQSPAQVDA--------YYAP 660

  Fly   479 QENNITIPVALLQ-PRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKS 542
            ..|.:..|..::| |....|  .|..:.|..:|.::.||:.|.|||.|.|||..|||..|||.::
 Worm   661 NNNEMIFPAGIMQFPFLTLG--VPNYITYGMVGAVIGHEVSHAFDDQGGQYDEMGNLNDWWDAET 723

  Fly   543 RYEFEERRKCFQAQYHEYQYGGSKLPESKDQS--ENIADSGGLKLAYAAYELWLGQQSEEVLQRE 605
            ..:|.|:.:||..||.......:.:..:...|  |||||:||:|.|:.||:.|  :.:...:...
 Worm   724 EEKFIEKTRCFVRQYENVHVVEADIHLNGQLSLGENIADNGGVKTAFNAYKAW--KSNTTGISEP 786

  Fly   606 TMEGLP-FNSRQLFFLGYAQLLCDDVQFLFQPWVSQSDRHAPSKYRVIGPLSNFQEFPWVFNCSQ 669
            .:.|.. |.|:|:|||.||...|..|:......:..:|.|||||||.:.||.|..||...|.|..
 Worm   787 ALPGFQNFTSQQMFFLAYANNWCSLVRPKHYIQIILTDVHAPSKYRAMIPLQNRPEFAKAFQCPI 851

  Fly   670 SAPMDPEYKCAIY 682
            .:||:||.||.::
 Worm   852 GSPMNPERKCQVW 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	M13	58..679	CDD:341056	178/719 (25%)
nep-21	NP_001360525.1	M13	193..862	CDD:341056	179/720 (25%)