Protein Alignment Nepl18 and nep-23

DIOPT Version :9

• Sequence 1: NP_651643.1
• Gene: Nepl18 / 43410
• FlyBaseID: FBgn0039611
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_503004.2
• Gene: nep-23 / 178472
• WormBaseID: WBGene00013785
• Length: 714
• Species: Caenorhabditis elegans
• Alignment Length: 728
• Identity: 153/728 - (21%)
• Similarity: 272/728 - (37%)
• Gaps: 208/728 - (28%)

  Fly    56 PEVSPCDDFYTHACGNWHRHNPAQLLGDVMTDNFKLISKGFDRR---LQRLLRANDLQ------S 111
            |...|||:||...||..|.|:               :..|..::   |:.|:|.....      |
 Worm    94 PSADPCDNFYQSVCGKQHEHS---------------LKSGLAKKHLILRNLIRETITNRKVTPTS 143

  Fly   112 ELEKKMQRFYMSCNLVHR----DDVHYKLALENVIRE---YGTLPALVGAQ-WNSSDFSWWRT-- 166
            :.|.:|::|:..|:...|    .|:..: ||.::.|:   .|:.||  |:: ||.|||:....
 Worm   144 KSENEMRKFHGICSKYQRANSSSDIAQQ-ALRDIFRDVQSIGSWPA--GSRNWNESDFNLNEMLN 205

  Fly   167 -----------VAQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQPDFKTINTRLTNLMEEVRTS 220
                       :.||..||..|::|..|  ...||            :..:...:.|:.|
 Worm   206 NLVKLGQRNFGLFQISFKYRDQLLISAE--EHRRN------------YSKLEPTILNIFE----- 251

  Fly   221 MDLQQYFGLSSSVAKHTAEQLTELERTFSSGGSGAATLQESLSLYTVADLQEK-----YSDHLNF 280
                     ::.:.....:.|.:||        |.|:|:..|..:...|..:|     ..|.:..
 Worm   252 ---------TNGLVPDRIQLLKDLE--------GFASLEALLKNHYYLDNMDKMKPAVLDDLVPS 299

  Fly   281 TEFLGLIL-----GEENI-PK--------SLYIYDEEYLDKALLTMRSTPLATQANYVLWKLLE- 330
            .:|:||:.     |:|:: ||        :..::::|.::...:.: .||..|.|||:::..::
 Worm   300 VDFMGLVKAMISPGKEHLMPKIELKTSVLNQTLFNDENMNLEAIIL-DTPKRTLANYLIFNFIDS 363

  Fly   331 --DFLVDAQPKDMVKWCTESTKKYFGKLAEHAVYKRYRNPDVESEVHKIWDQIKGIFRQRL--LG 391
              |.||..........|.:....|..:.:.....:.|    |:.|...:..|:....|..|  |.
 Worm   364 SLDHLVFETTSQKGNTCEDKVITYLPRASLRVFIRNY----VDKENRDLITQLAEKTRIALHTLV 424

  Fly   392 DKLDWISNATRTLAIEKLERM---------------------HLNINSYDEENFENVYGEVFIDR 435
            ....|:...::.||::|:..|                     :||::|.|          .:...
 Worm   425 QNSTWLKAESKQLALDKINAMGKMIGYPDFFEPPGTLDGMFKNLNLDSSD----------TYYTA 479

  Fly   436 LNYVSNVQQLLIAKGIRFVARINQPAD-SVDATELLGFTPAYNIQENNITIPVALLQPRYFWGD- 498
            ||   .:::..:.:.:.:.|. ..|.| .:...|:..:   |.|..|.:.    .|.|  |:.|
 Worm   480 LN---KLERYFVEQKMDYFAE-ETPLDPDLRVFEMNAY---YYIPGNQLN----FLAP--FFDDP 531

  Fly   499 ----QYPEALKYATLGYLLAHEMLHGFDDD-------GRQYDASGNLAPWWDLKSRYEFEERRKC 552
                .||:.:..|..|.::.|||.|.|...       ||:.        |...:...|:|.|.:|
 Worm   532 MFDSTYPDYVNIAMSGNIIGHEMGHAFGPHAILRTVRGREV--------WMKPEELAEYESRAQC 588

  Fly   553 FQAQYHEYQ-------YGGSKLPESKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQRETMEGL 610
            ...||.||.       :.|.|:.:     |.:||:.|.:::      |...:|.::.....:.|.
 Worm   589 LANQYSEYDDPDFGRVFDGGKVID-----ELVADNIGREVS------WKMFKSLDLTNATRIIGF 642

  Fly   611 -PFNSRQLFFLGYAQLLCD-----DVQFLFQPWVSQSDRHAPSKYRVIGPLSNFQEFPWVFNCSQ 669
             .::..||:|...|...|.     |::      .|....|....:||.|..:|..||...|||..
 Worm   643 EDYDIDQLYFRVGALTHCTPHAMRDLK------GSIESSHPRKAFRVNGVYANLPEFARAFNCPT 701

  Fly   670 SAPMDPEYKCAIY 682
            .:||:|..||.::
 Worm   702 GSPMNPRKKCDMF 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	153/726 (21%)
		M13	58..679	CDD:189000	150/721 (21%)
nep-23	NP_503004.2	M13	96..711	CDD:189000	150/721 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920