DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and nep-16

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001023203.2	Gene:	nep-16 / 177541	WormBaseID:	WBGene00018472	Length:	868	Species:	Caenorhabditis elegans

Alignment Length:	706	Identity:	145/706 - (20%)
Similarity:	259/706 - (36%)	Gaps:	160/706 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 MKTMMKPEVSPCDDFYTHACGNWHRHNPAQLLGDVMTDNFKLISKGFDRRLQRL--LRANDLQSE 112
            :.:.:..|:.||::||.::|..:|        ..........:|:..|..|:|:  |.:::..|.
Worm   246 LSSCIDDEIEPCENFYRYSCQRYH--------SQTADKQMSFLSQLKDESLRRMHSLLSSEEDSR 302

  Fly   113 LEKKMQR----FYMSC-NLVHRDDVHYKLALENVIREYGTLPALVGAQ-WNSSDFSWWRTVAQIQ 171
            |..|..|    .|.:| |.|.|.. :....|...||.:...|.|...| :::..:||.|....:.
Worm   303 LLPKSARLSRSLYSACMNAVLRSS-NAPTDLLTFIRNFPCGPLLRDCQNFHADSYSWERHAGMLD 366

  Fly   172 HKYGKQIIIGLEIMHDIRNTSVNRV--YISQPDFKTINTRLTNLME--------------EVRTS 220
            ...|:..:|..:  .|:.....:::  .|..||.    |.:..|:|              |....
Worm   367 WYAGRYNLIVYD--RDVHPQDRSKIILQIKPPDL----TPIVGLIERDLIDLARPSPTEFEPLLQ 425

  Fly   221 MDLQQYFGLSSSVAKHT--------AEQLTELERTFSS---GGSGAATLQESLSLYTVADLQEKY 274
            :.|:|  .|.|:.|:.:        ..||.|:.|....   ....:|:|..:.:..|:.::.:..
Worm   426 LSLRQ--NLLSAFARDSLLRDPRDVQSQLDEVARLMVDLYISARQSASLTPNTTYMTIGEMFQAL 488

  Fly   275 SDHLNFTEFLGLILG------EENIPKSLYIYDEEYLDKALLTMRSTPLATQANYVL----WKLL 329
             ..|...|||...|.      |.::   |.|.|.:|..:....|..|.....|||:|    |.|.
Worm   489 -PQLYLREFLDAQLSNTYRWTETDM---LSIQDYDYFARLSDIMAQTSRQAVANYLLTVTVWNLK 549

  Fly   330 EDFLVDAQPKDMVKW--CTESTKKY-FGKLAEHAVYKRYRNPDVES-EVHKIWDQIKGIFRQRLL 390
            :   ....|:|...|  |.:....: .|:       |.|.:...:: ::.||.:     |.|.|
Worm   550 Q---YSYSPRDQYGWRECVDQISSFEIGR-------KMYVDKASQTIDLPKIQE-----FLQNL- 598

  Fly   391 GDKLDWISNATRTLAIEKLERMHLNINS-----------YDEENFENVYGEVFIDRLNYVSNVQQ 444
              |:|::| ..|:..::.|.    |||.           .:||.......:|.::..:|..::.:
Worm   599 --KIDFLS-VHRSTPLQYLS----NINRLGFYVGFPRRLQNEELIWKPVSQVSLNETDYFDSMIR 656

  Fly   445 LLIAKGIRFVARINQPADSVDAT--ELLGFTPAYNIQENNITIPVALLQPR-YFWGDQYPEALKY 506
            :..|:....:::|....|:.|.|  .:...|..||.....|.||:|.::|. |..||:.|....|
Worm   657 VGKAERDYTMSQIGTYLDNDDTTTFPISDPTMLYNSNVGAIVIPLAFIEPPIYLPGDEVPMYGIY 721

  Fly   507 ATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSKLPESK 571
            ::||......:...|               |..|....:.|    |....:..:      |..::
Worm   722 SSLGITTLQMISKVF---------------WQGLDKTSQLE----CLDNVFRGF------LDANR 761

  Fly   572 DQSENI----------ADSGGLKLAYAAYELWLGQQSEEVLQRETMEGL-PFNSRQLFFLGYAQL 625
            .:|.||          ||:  .|.|..:|..|  |....:...:|:... ..:|.:...|.::.:
Worm   762 QRSPNIEPELLATIELADA--FKSALYSYAKW--QNDHHIHHEKTLPAFDSTDSMRSLMLTFSTM 822

  Fly   626 LCDDVQFLFQPWVSQSDRHAPSKYR-VIGPLS-NFQEFPWVFNCSQSAPMDPEYKC 679
            .|           |.......|.|. :|..:: |.:.|...|||:.|:.:.....|
Worm   823 FC-----------SGEGSEPGSDYEAMINTVAENSRMFSIHFNCNNSSRLYNRRTC 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	145/702 (21%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	143/696 (21%)
nep-16	NP_001023203.2	GluZincin	254..>725	CDD:387391	111/514 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010