DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and nep-17

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001254395.1	Gene:	nep-17 / 174996	WormBaseID:	WBGene00010070	Length:	1589	Species:	Caenorhabditis elegans

Alignment Length:	819	Identity:	192/819 - (23%)
Similarity:	312/819 - (38%)	Gaps:	230/819 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 DYAKKIIVQAKVAEM-----------------KTMMKPEVSPCDDFYTHACGNWHRHNPAQLLGD 83
            |.|.|::..|:.|::                 |..:...|.||:|||.:.|||:.        ||
Worm    73 DIASKVLNVAQPAKVSPGTDKYNSYQQVVQLFKASVNLSVDPCNDFYAYTCGNFK--------GD 129

  Fly    84 V---MTDNFKLISKGFDRRLQRLLRANDL---QSELEKKMQRFYMSCNLVHRDDVHYKLALENVI 142
            :   ::||     ...:..:.||  .||.   .:.|..:..|:|....:..|.:       .|.|
Worm   130 MSFDISDN-----SNTNDMVTRL--TNDTYISTAPLPVQQTRWYFDTCVNARQN-------WNTI 180

  Fly   143 REYGTLPALV--------GAQWNSSDFSW----WRT-VAQIQHKYGKQIIIG---LEIMHDIRNT 191
            .:...:.|.:        |...||:.|.:    .:| |.....::|...:.|   .:.:..|.:.
Worm   181 ADGSVVTAAINQLAAGNPGKHENSTKFPFPMLDQKTDVTTFPDRFGLGYLTGSLTAQGVDTIISA 245

  Fly   192 SVNRVY------------ISQP-----------DFKTINTRLTNLMEEVRTSMDLQQYFGLSSSV 233
            .|:..:            |.||           ||..:|..||..:.|....:...|...|.:::
Worm   246 GVDTNWKDPAGPEGFAYLIDQPTTFAPNTYYLKDFDALNASLTYQITENMLQLAKVQNKTLDANI 310

  Fly   234 AKHTAEQLTELE----RTFSSGGSGAATLQESLSLYTVADLQEKY-SDHLNFTEFLGLILGEENI 293
            .....:.:.:|:    ..||:..:.......|.:..|:..|..:| .|..::..||.:.:|..
Worm   311 LAKDVQDIIKLDYLLATKFSTDDTTRRQYDRSYNPNTLPQLLTQYHKDVFSWHMFLPIAVGTA-- 373

  Fly   294 PKSLYIYDEEYLDKAL---------LTMRSTPL-----------------ATQANYVLWKL---L 329
                    |..|||.|         :||..|.|                 ....||..::|   |
Worm   374 --------EHVLDKLLDQGSGYNYYITMEPTKLNMLLTSLNKDNTLGITPRALVNYFYYRLVDSL 430

  Fly   330 EDFL--------------VDAQPKDMVKWCTESTKKYFGKLAE---HAVYK--------RYRN-- 367
            .:||              ::.||....:......:||..||.|   .|.|.        :|.|
Worm   431 SEFLPAPPAGNMIRPFVKIERQPVGRPRHVLPEDRKYERKLIEDLTEAQYSCAQETIDIQYANAR 495

  Fly   368 -------------PDVESEVHKIWDQIKGIFRQRLLGDKLDWISNATRTLAIEKLERMHLNINSY 419
                         .:|...|.|:...|...||..:  |:|:|::.:|:..|..|:|.:..|| :|
Worm   496 LFIDQIYPTATDRKNVREHVAKVASSIVIGFRSMI--DQLNWMTPSTKKGAYNKIENLVKNI-AY 557

  Fly   420 DE--------------ENF--ENVYGEVF--IDRLNYVSNVQQLLIAKGIRFVARINQPADSVDA 466
            .:              .||  .:.|.::|  :...|..|...||           :..|||....
Worm   558 PDWITDDAQLTAYHAPMNFTKTDTYVDMFFNVQNFNLYSQWDQL-----------VQGPADRTGF 611

  Fly   467 TELLGFTPA-YNIQENNITIPVALLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDA 530
            ....|.|.| |..:.|:||.|..:|: :.|:...:|.::.:..:|.:..||:.|||||.|.|::.
Worm   612 NGPPGITNAWYQPELNSITFPAGILK-KPFYDFNWPASVNFGAMGVIAGHELTHGFDDQGVQWNG 675

  Fly   531 SGNLAPWWDLKSRYEFEERRKCFQAQYHEY------QYGGSK-LPESKDQSENIADSGGLKLAYA 588
            .|.|:.|.|..|:..|....:|...:|..:      .||.:. :..::.|.|||||:||:..|:.
Worm   676 VGTLSGWMDATSKVSFTNMAQCVVNEYSGFCPLDKATYGSAACIDGAQTQGENIADNGGIHSAFR 740

  Fly   589 AYELWLGQQSEEVLQRETMEGLP------FNSRQLFFLGYAQLLCD----DVQFLFQPWVSQSDR 643
            ||:.::.....:.:       ||      ||..|||||.:||:.|.    |.|||.|..|   |.
Worm   741 AYKNYVDLYGPDPV-------LPDPQLQYFNPDQLFFLSFAQVWCQMPYTDAQFLRQILV---DV 795

  Fly   644 HAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
            |:||.|||:|.:.||..|...||| .|:...|:..|.::
Worm   796 HSPSIYRVLGTIQNFPAFKTAFNC-PSSTYAPDNHCNVW 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	186/782 (24%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	185/775 (24%)
nep-17	NP_001254395.1	PepO	108..833	CDD:226118	186/782 (24%)
		M13	112..830	CDD:189000	185/775 (24%)
		PepO	880..1583	CDD:226118
		M13	884..1581	CDD:189000
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020