Protein Alignment Nepl18 and nep-1

DIOPT Version :10

• Sequence 1: NP_651643.1
• Gene: Nepl18 / 43410
• FlyBaseID: FBgn0039611
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_496490.2
• Gene: nep-1 / 174787
• WormBaseID: WBGene00013926
• Length: 754
• Species: Caenorhabditis elegans
• Alignment Length: 710
• Identity: 170/710 - (23%)
• Similarity: 291/710 - (40%)
• Gaps: 124/710 - (17%)

  Fly    58 VSPCDDFYTHACGNWHRHNPAQLLGDVMT--DNFKLISKGFDRRLQRLLRANDL--QSELEKKMQ 118
            :.|||||:.:||..|...:|   :.|.:|  ..|....:.....:::|...|..  .|:....::
 Worm    84 LDPCDDFFEYACRAWVDSHP---IPDDLTSYSQFTATREKVLAEMRKLYEDNTSIPTSKSIALIK 145

  Fly   119 RFYMSC------NLVHRDDVHYKLALENVIREYGTLPALVGAQWNSSDFSWWRTVAQIQHKYGKQ 177
            :.|.:|      |.|...|:..|      |:.||..|.:...:|..|.|...:.::.........
 Worm   146 QIYNTCMDTEKHNAVGARDLLEK------IKTYGYWPMVHNEKWRESTFDLTKLLSNTIQSRDVS 204

  Fly   178 IIIGLEIMHDIRNTSVNRVYISQPDFKTINTRLTNLMEEVRTSMDLQQY---------------- 226
            :........|.||.|...:...|.......:.....::|.:....::.|
 Worm   205 VFFDFGPAEDSRNVSRRLLSFDQGSLGLGYSTRDYYLDEKKYEKQMKAYRKYTIGKVRYYTEDAG 269

  Fly   227 FGLSSSVAKHTAEQLTELERTFSSGGSGAATLQESLSLYTVA---DLQEKYSD------HLNFTE 282
            ..::.|..:...:::...|:.::.........:....||.|.   ||:|..|.      .|:.|.
 Worm   270 MAVNESKIESDVDEIIAFEKEWAQILVAEEDRRNYTKLYNVRRFDDLKEYMSIIDWKKLTLSTTP 334

  Fly   283 FLGLILGEENIPKSLYIYDEEYLDKALLTMRSTPLATQANYVL------W-----KLLED----- 331
            ||.....:.|  .|:.|.|.|||.|....:::|......||:|      |     |..||
 Worm   335 FLVHSYLKTN--PSIIISDVEYLQKMNTLLQNTDPRIVTNYILLRWAGSWSQEIGKKYEDLQQEF 397

  Fly   332 -FLVDAQPKDMVKW--CTESTKKYFGKL--AEHAVY-KRYRNPDVESEVHKIWDQIKGIFRQRLL 390
             |.:..:.:...:|  |..|..   |||  |..::| ::|.:.:.::....:...::..||..:.
 Worm   398 AFQMYGRKQRQPRWKDCVSSAG---GKLSYASGSMYVRKYFDANAKNTTLDMITDLQEAFRNMMH 459

  Fly   391 GDKLDWISNATRTLAIEKLERMHLNINSYDEENFENVYGEVFIDRLNYVSNVQQL---------- 445
            .:  ||:...|:..|:||.::|...|...|                 ::.|.::|
 Worm   460 AN--DWMDAETKKYALEKADQMLKQIGYPD-----------------FILNDEKLDDWYKGLEGA 505

  Fly   446 -------LIAKGIR-----FVARINQPADSVDATELLGFTPA-YNIQENNITIPVALLQPRYFWG 497
                   |:.|.|:     :..|:.:|.:..:.........| |:...|.|..|..:||..:| .
 Worm   506 PEDSFSQLVEKSIQWRNNFYYRRLLEPVNRFEFISSAAVVNAFYSPTRNAIAFPAGILQQPFF-D 569

  Fly   498 DQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQY 562
            .::|:||.|..:|.::.||:.|||||.|||:|..|||..|||..:..:|.||.:|...||.:.:.
 Worm   570 ARFPKALNYGGIGAVIGHEITHGFDDTGRQFDNVGNLRDWWDNTTSSKFNERTQCIIEQYADVKL 634

  Fly   563 GGS--KLPESKDQSENIADSGGLKLAYAAYELWL---GQQSEEVLQRETMEGLPFNSRQLFFLGY 622
            .|:  ::.....|.|||||:||:|.|:.||:.:|   |.|...:.|.|::     .:.||||:||
 Worm   635 RGTDLRINGKLTQGENIADNGGIKQAFKAYKSYLEKHGGQEARLPQFESL-----TNEQLFFVGY 694

  Fly   623 AQLLCDDVQFLFQPWVSQSDRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
            ||:.|.......:..:..:|.|:|...||...|:|..||...|.|...:||:|..:|.::
 Worm   695 AQVWCGAKTPETKTLLLLTDPHSPETARVNTVLTNQPEFAEAFKCPAGSPMNPTKRCVVW 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	M13	58..679	CDD:341056	169/705 (24%)
nep-1	NP_496490.2	M13	85..751	CDD:341056	169/704 (24%)