Protein Alignment Nepl18 and nep-5

DIOPT Version :10

• Sequence 1: NP_651643.1
• Gene: Nepl18 / 43410
• FlyBaseID: FBgn0039611
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_001364754.1
• Gene: nep-5 / 173933
• WormBaseID: WBGene00017393
• Length: 694
• Species: Caenorhabditis elegans
• Alignment Length: 690
• Identity: 142/690 - (20%)
• Similarity: 259/690 - (37%)
• Gaps: 171/690 - (24%)

  Fly    48 AEMKTMMKPEVSPCDDFYTHACGNWHRHNPAQLLGDVMTDNFKLISKGFDRRLQRLLRANDLQSE 112
            ||:..:|...|:||::|:.|.|..:   ||.:              |.|    :||::..::|.:
 Worm   118 AELLELMDSSVNPCENFHHHVCNGF---NPRK--------------KDF----ERLMKLINIQEK 161

  Fly   113 LEKK-----MQRFYMSCNLVHRDDVHYKLALENVIREYGTLPA----LVGAQW-----------N 157
            .:.:     ::|....|.:...:::|....|.::|     ||.    |:...|           :
 Worm   162 PDHRKAVNVVRRMLSKCAMGKTEEIHQVGRLSSII-----LPGLPFPLLNNSWTKPSDPISTSNS 221

  Fly   158 SSDFSW---WRTVAQ-IQHKYGKQIIIGLEIMHDIRNTSVNRVYISQPDFKTINTRLTNLMEEVR 218
            |:.:|:   .:.:|. |.|.......:|::...|    |...:::.:| |..:   |||.  :.|
 Worm   222 STTYSYPFLTKILAHIILHNPDDAGFVGIKPSSD----SEFSLFVVKP-FSPV---LTNF--KFR 276

  Fly   219 TSMDLQQYFGLSSSVAKHTAEQLTELERTFSSGGSGAATLQESLSLYTVADLQEKYS-------- 275
            ...|:     |..:..:.:...:.:||            ......|..|..||.|..
 Worm   277 NMYDI-----LKRNAPESSTNGMIDLE------------FDRQRQLNDVIKLQTKLEKIEFKADP 324

  Fly   276 DHLNFTEF---LGLI-----------LGEENIPKSLYIYDEEYLDKALLTMRSTPLATQANYVLW 326
            :.:|.||.   :.:|           .|..::.:.:|.::..|.::....:.|||..|..|::..
 Worm   325 EVVNLTEIQRQMPIIDWKRLIDSWIPNGYAHLKEKVYGFNTSYYEEINAIISSTPSETIYNFLFL 389

  Fly   327 KLLEDFLVDAQPKDMVKWCTESTKKYF-GKLAEHAVYKRYRNPD----VESEVHKIWDQIKGIFR 386
            :....||......|:...|........ ||:    |......|:    :...:|.|.||:|
 Worm   390 RFSFKFLRTEVASDLEDTCLHQLSTTIPGKI----VLYGSEEPEALNLLNGMLHTIKDQLK---- 446

  Fly   387 QRLLGDKLDWISNATRTLAIEKLERMHLNINSYDEENFENVYGEVFIDRLNYVSNVQQLLI---A 448
             |.|. .|.|:.:.....|.:|..:.........|:..:.:.|:: ....||:|.:|.:|:   .
 Worm   447 -RSLA-TLKWMDSRGIEEAQKKFNKTKTVFGFTGEDLIDELVGKI-TPESNYISTLQNVLLWQTR 508

  Fly   449 KGIRFVARINQPADSVDATELLGFTPAYNIQENNITIPVALLQPRY-FWGDQYPEALKYATLGYL 512
            ...:.||..|       .|..|.....|::::|.|||..|||  .| |.....|....:||:...
 Worm   509 NMFKSVAENN-------VTVFLNSEVFYSVEKNEITISRALL--HYPFMSANLPNYTNFATIASK 564

  Fly   513 LAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSKLPESKDQSENI 577
            :..:|:|.||:.||.||:.||...||:.::...|:...:||....... :|.|
 Worm   565 ILPQMIHIFDERGRFYDSDGNHRNWWNTETERYFQIIVQCFDGMMQNV-FGVS------------ 616

  Fly   578 ADSGGLKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQ-LFFLGYAQLLCDDVQFLFQPWVSQS 641
                 :.:.:.||:     .::|  ...|:.|:..:|.: |||....:.:|          .|..
 Worm   617 -----VSIGWNAYD-----STKE--PYATLPGIQQSSDEALFFYSMVKTMC----------TSDP 659

  Fly   642 DRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAI 681
            |       .|...|::..:|...|.|:....|:|..||.:
 Worm   660 D-------NVNEALASVPQFNSAFKCNNGTKMNPPTKCKL 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	M13	58..679	CDD:341056	137/676 (20%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:472708	138/677 (20%)