DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and nep-12

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001364537.1	Gene:	nep-12 / 173824	WormBaseID:	WBGene00017842	Length:	832	Species:	Caenorhabditis elegans

Alignment Length:	715	Identity:	184/715 - (25%)
Similarity:	303/715 - (42%)	Gaps:	135/715 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 MKPEVSPCDDFYTHACGNWHRHNPAQLLGDVMTDNFKLIS------KGFDRRLQRLL----RAND 108
            |..:.:||:|||..|||.:....       |:.::.|.::      |..||.|:.:|    |.|.
Worm   167 MNRDANPCEDFYEFACGKYATRK-------VIAEHEKKVTVLSEMKKEMDRHLKDILEKTSRENT 224

  Fly   109 LQSELEKKMQRFYMSC-NLVHRDDVHYKLALENVIREYGTLPALVGAQWNSSDFSWWRTVAQIQH 172
            .:|  .|..|.::.|| :...:||:..: .|.::|...|..|.|..|:::|.||. |..:|....
Worm   225 TRS--MKLAQIYFDSCMDEFSQDDLGVQ-PLMSMISNLGGWPLLTNARFDSIDFQ-WEVLAGHLA 285

  Fly   173 KYGKQIIIGLEIMHDIRNTSVNRVYISQPDFKTINTRLTNLMEEVRTSMDLQQYF---------- 227
            .||...|..:.:.....::..|.:..|.|   .:.........||.:|....||:
Worm   286 LYGVDGIFRVFVHSSFDDSDKNVLMFSPP---KLFLEKKKFYREVPSSNVYLQYYRQYILSLLSL 347

  Fly   228 -GL----SSSVAKHTAEQLTELERTFSSGGSGAATLQESL--SLYTVADLQEKYSDHLNFTEFLG 285
             |:    .:.|.::..:.:.:.||..::......:...|.  ::.|..:.:.|| |.:|:..|
Worm   348 LGVDMEDETGVIEYQVDDIIDFERRIANLTRIELSRNHSSINNMITFGEFKRKY-DKINWDAF-- 409

  Fly   286 LILGEE------NIPKSLYI--YDEEYLDKALLTMRSTPLATQANYVLWKLLEDF---------- 332
              ..||      .:|.||.|  .|..|.|.....::|.||::..|:::|.|:.::
Worm   410 --FNEEMRGNLGRMPDSLVINVVDVNYFDNLYSLIKSKPLSSINNFLMWCLVSNYDMYLPAKYRK 472

  Fly   333 -LVDAQPK------DMVKW--C-------------TESTKKYFGK----LAEHAVYKRYRNPDVE 371
             ::|.:.|      |...|  |             ||..:|:|.|    :||..:
Worm   473 PMLDFRQKMYGVSSDDPLWEVCVGEVRENLAMPLSTEYAQKFFTKKDKLVAEDMI---------- 527

  Fly   372 SEVHKIWDQIKGIFRQRLLGDKLDWISNATRTLAIEKLERMHLNINSYDEENFENV----YGEVF 432
                   ..:|....|.||  ..|||..:||..|:.||:.|...|...|....|..    |..|.
Worm   528 -------RDLKKAMEQTLL--NADWIDESTREAALMKLDAMGHKIGFPDSLLNETAVLLPYAGVR 583

  Fly   433 IDRLNYVSNVQQLLIAKGIRFVARINQPADSVD-ATELLGFTPAYNIQENNITIPVALLQPRYFW 496
            :....|..|...|..|.....::::::....:| |:.::.....:....|.|..|..:||...|.
Worm   584 LTANQYFDNAISLKKAAYRDALSKLHRTPSLIDWASPIIAVDAFHYFTGNEIIFPAGILQFPMFV 648

  Fly   497 GDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQ 561
            .|. |....|..:|..:.||:.||:||.|.|||..|||..||..::...|:::::||.|||
Worm   649 PDA-PAFSNYGAIGMGIGHEITHGYDDLGAQYDDKGNLRGWWHTETMTTFQKKKQCFVAQY---- 708

  Fly   562 YGGSKL-PESKDQ-------SENIADSGGLKLAYAAYELWLGQQSEEVLQRETMEGL-PFNSRQL 617
              |||: |::..:       .|||||:|||::|:.||:|    :|:...:...:.|| .|:..||
Worm   709 --GSKIEPQTGRKVDGKMTIGENIADNGGLRVAFQAYQL----RSDREKETRRLPGLTDFSPNQL 767

  Fly   618 FFLGYAQLLCDDVQFLFQPWVSQSDRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
            |||.||...|:.::......:..:|.|:...:||..||.|...|...|:|...:||:|..||.|:
Worm   768 FFLAYANTWCEALKPSAIDHIMDTDVHSLGMFRVNVPLQNLPAFSKEFDCPIGSPMNPFEKCRIW 832

Fly 683 682
Worm 833 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	183/713 (26%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	180/706 (25%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	181/707 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880