DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl18 and nep-11

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_494538.1	Gene:	nep-11 / 173685	WormBaseID:	WBGene00017557	Length:	848	Species:	Caenorhabditis elegans

Alignment Length:	811	Identity:	203/811 - (25%)
Similarity:	332/811 - (40%)	Gaps:	176/811 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLWLCLLVAIVPAMAKPSDA------------------GDPFADDLTSDYAKKIIVQAKVAEMKT 52
            :|..|||.|::.|:...:|.                  |||..:...:  |:...|...|.|..|
Worm    80 LLLFCLLTAVLLAVIINTDKRIEAMKTDHATQTEHAGFGDPTENPTKT--AEDPRVPPIVPEAPT 142

  Fly    53 MMKPEVS---------------------------------PCDDFYTHACGNWHRHNPAQLLGDV 84
            ..:|||:                                 |||||:..|||.|:..:|      :
Worm   143 SPEPEVTTSTEKPKEPEVCSTPGCVRAATHFLNAMNTSVDPCDDFFEFACGQWNDQHP------I 201

  Fly    85 MTDNFKLISKGFD---------RRLQRLLRANDLQSELEK-KMQR-FYMSC-NLVHRDDVHYKLA 137
            ..|.:     ||.         |:..|:|...::.:|.|. .|.| .|.|| |....|::.....
Worm   202 PDDMY-----GFGTFAYAREQVRQQLRVLLEQEVVTESESINMARATYRSCMNKTQLDELMTGPL 261

  Fly   138 LENVIREYGTLPALVGAQWNSSDFSWWRTVAQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQP- 201
            .| .:.|.|..| |:...|:.:.|::...:...:..||..:...|.|..|.:|||.|.::|.|.
Worm   262 FE-TLTELGEWP-LLQENWDKTKFNFTSLLVNSRRDYGVDVFFQLYIYADSKNTSRNTLFIDQST 324

  Fly   202 --------DFKTINTRLTNLMEEVRTSM-DLQQYFGLSSSVAKHTAEQLTELERTFSSGGSGAAT 257
                    |:....|..::.|...|..: .:........::.:..:|...::|:........|..
Worm   325 LALGRGTRDYYLNTTLFSSHMTAYRKYLRQIAHLLKTDGNLTRSESEMNADIEKIIDFEIELAKI 389

  Fly   258 L------QESLSLYTVADLQEKYS-----DHLNF------TEFLGLILGEENIPKSLYIYDEEYL 305
            :      :.:..||....:|:.|:     |.:.|      ::...|...|..|    .|.:.|||
Worm   390 IVAEDERRNNTRLYNKRQIQDLYNLLPQVDWVPFFQSIAPSDLTHLFHNETEI----IICEIEYL 450

  Fly   306 DKALLTMRSTPLATQANYVLWKLL---------------EDFL--VDAQPKDMVKW--CTESTKK 351
            ......:..|.:....|||||:::               :|||  :..|.:...:|  |.:....
Worm   451 QHVSELIEKTDVGLLTNYVLWRVVQSNVRYLDERFEDIKQDFLKVMTGQQQSPPRWKDCAQVPST 515

  Fly   352 YFGKLAEHAVYKRYRNPDVESEVHK-------IWDQIKGIFRQRLLGDKLDWISNATRTLAIEKL 409
            .. .||..|:|.:....  ||:.|:       :.:....:.||.      ||:...|:.:||||.
Worm   516 VL-PLAAGAIYVQAHFQ--ESDKHEALRMIMHLRNSFADLVRQN------DWMDEETKAVAIEKA 571

  Fly   410 ERMHLNINSYDEEN----FENVY-GEVFIDRLNYVSNVQQLLIAKGIRFVARINQPADSVDATEL 469
            ..|..||...|..|    .:..| |....|...|...:::.::....|...::.:|.|..:
Worm   572 NSMINNIGYPDVTNDLPKLDKQYLGLSISDSDTYYYIMKKSVVWMQSREFQKLTKPFDKHE---- 632

  Fly   470 LGFTPA-----YNIQENNITIPVALLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYD 529
            ...:||     |:.::|.||.|..:|||.:|.| .:|:|:.|..:|.::.||:.|||||.|.|||
Worm   633 FDISPAVVNAFYSPEKNAITFPAGILQPPFFSG-TFPKAVNYGAIGAVIGHEITHGFDDQGSQYD 696

  Fly   530 ASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSKLPESK-------DQSENIADSGGLKLAY 587
            ..|||..||...|...|:.||:|...||..|     .:|::.       .|.|||||:||:|.|:
Worm   697 KDGNLHNWWSESSLNSFDTRRRCIVEQYGNY-----TVPKTNFRVNGKLTQGENIADNGGVKEAF 756

  Fly   588 AAYELWLGQQSEEVLQRETMEGL-PFNSRQLFFLGYAQLLCDDVQFLFQPWVSQSDRHAPSKYRV 651
            .||:.::.:..||    ..:.|| .:.:.|:||:.||...|...:.........:|.|:|..:||
Worm   757 QAYQKYVTENGEE----PRLPGLQQYTNEQIFFVSYAHFWCGKKKEAAAMQQVLTDEHSPEVFRV 817

  Fly   652 IGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
            ||.|||.|.|..|:.|.::||::|::||.::
Worm   818 IGVLSNMQAFADVYKCPRNAPVNPDHKCIVW 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	188/743 (25%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	184/736 (25%)
nep-11	NP_494538.1	PepO	174..848	CDD:226118	185/713 (26%)
nep-11	NP_494538.1	M13	181..845	CDD:189000	183/703 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020