Protein Alignment Nepl18 and nep-9

DIOPT Version :10

• Sequence 1: NP_651643.1
• Gene: Nepl18 / 43410
• FlyBaseID: FBgn0039611
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_494531.2
• Gene: nep-9 / 173683
• WormBaseID: WBGene00017554
• Length: 700
• Species: Caenorhabditis elegans
• Alignment Length: 682
• Identity: 152/682 - (22%)
• Similarity: 276/682 - (40%)
• Gaps: 104/682 - (15%)

  Fly    49 EMKTMMKPEVSPCDDFYTHACGNWHRHNPAQLLGDVMTDNF--KLISKGFDRRLQRLLRANDLQS 111
            |:|.........|:|||...|.|:..|.......|......  ||: :||   |||  ..:...|
 Worm    75 ELKAYSDTATKSCEDFYKATCENYKDHQALDRHRDCKKRKAVNKLV-RGF---LQR--DESTFTS 133

  Fly   112 ELEKKMQRFYMSCNLVHRDDVHYKLALENVIREYGTLPALVGAQWNSSDFSWWRTVAQIQHKYGK 176
            |.|..::..:..|:.:.|:..:  |.:...|::.|:.|.| ...|..|.|:....:|::. |.|
 Worm   134 ESESAIKLIFGKCDELSRNTSY--LDIFKDIKKIGSWPVL-EHNWKDSMFNLDDVIAKLV-KLG- 193

  Fly   177 QIIIGLEIMHDIRNTSVNR--VYISQPDFKTINTRLTNLM----------EEVRTSMDLQQYFGL 229
            ....|| ...::|..:...  |::|....:.|:.....::          :....|.||:.|
 Worm   194 STDFGL-FKLELRKLAFGHFAVFVSSKQEQNIHQLEKTILGILKANGIQQDRKELSDDLKDY--- 254

  Fly   230 SSSVAKHTAEQLTELERTFSSGGSGAATLQESL---SLYTVADLQEKYSDHLNFTEFLGLILGEE 291
             |....|..|...  |.|:......|.::.|:|   ||.|...|:....|..|......||..
 Worm   255 -SDFKNHLKEFYQ--EETYIEYRLYAGSIVENLGISSLTTQMALKSTGLDVFNHVNQRTLITN-- 314

  Fly   292 NIPKSLYIYDEEYLDKALLTMRSTPLATQANYVLWKLLEDFLVDAQPKDMVKWCTESTKKYFGKL 356
               .||:..:|..|.   :.::.||..|.||::::..::....|.  .:..|.|.|:......:.
 Worm   315 ---SSLFFGEENNLG---MIIQKTPKRTLANFLIFHFIDVMTTDL--ANATKACKETLIDLLPRA 371

  Fly   357 AEHAVYKRYRNPDVESEVHKIWDQIKGIFRQRL----LGDKLDWISNA-TRTLAIEKLERMHLNI 416
            :...:.:.:.|.|.:.::.|:...:|....:.:    ...|...:.:| .:...|:|::.:.: :
 Worm   372 SIQVLSRNFVNEDAQDDMVKMAQDLKTKITEMIDNSPFFTKFHLVFDAEEQKKLIQKVKAIGI-V 435

  Fly   417 NSYDEENFENVYGEVFIDRLNYVSN------VQQLLIAKGIRFVARINQPADSVDATELLGFTPA 475
            ..|.:|..:..:     :|||...:      :|:|...:..:.:..:....|..| |.:.| :..
 Worm   436 TEYPQEVLDRDF-----ERLNLTPSDSIYRTIQKLRRLRSEQLIEHLGGDLDPTD-TRVWG-SAH 493

  Fly   476 YNIQENNITIPVALLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDL 540
            |:...||:||...::...|| ...||..:....:|::|..|:....|....:.|..|....|...
 Worm   494 YDQTTNNLTIFAPIIDGPYF-DTSYPNYVNQFLMGFILGRELGRSLDSVRIRKDEKGQTENWLKP 557

  Fly   541 KSRYEFEERRKCFQAQYHEYQYGGSKLP---ESKD---------QSENIADSGGLKLAYAAYELW 593
            :|...|:|..||:..:|.:     |..|   |||.         |:|..||..|.:.::.|: :.
 Worm   558 ESLKRFDEHLKCWAEKYDK-----SADPLKSESKGIRQIEGRYIQNEMFADFIGHEASWRAF-MK 616

  Fly   594 LGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQFLF--QP------WVSQSDRHAPSKYR 650
            |..::||||  ||.:.:..  |::||         :||.|:  :|      |:|..:.|....:|
 Worm   617 LDVKNEEVL--ETFKVIKL--RRMFF---------NVQALYFCRPPSGSTDWLSYQEHHQHYSFR 668

  Fly   651 VIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
            |.|...|..:|...|.|:....|:|:.||:::
 Worm   669 VNGAFKNMPQFALAFECASDDDMNPQNKCSMF 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	M13	58..679	CDD:341056	148/668 (22%)
nep-9	NP_494531.2	GluZincin	87..698	CDD:472708	149/666 (22%)