DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl18 and Ecel1

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001264854.1	Gene:	Ecel1 / 13599	MGIID:	1343461	Length:	775	Species:	Mus musculus

Alignment Length:	758	Identity:	192/758 - (25%)
Similarity:	316/758 - (41%)	Gaps:	138/758 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LCLLVAIVPAM--AKPSDAGDPFADDLTSDYAKKIIVQAKVAEMKTMMKPEVSPCDDFYTHACGN 71
            ||.::|.:.|:  ..|..||...|........|.....|:.  :...:...:.||.|||:.|||.
Mouse    72 LCAILAAMLALKYLGPGAAGGGGACPEGCPERKAFARAARF--LSANLDASIDPCQDFYSFACGG 134

  Fly    72 WHRHNPAQLLGDVMT-DNFKLISKGFDRRLQRLLR--ANDLQSELEKKMQRFYMSCNLVHRDDVH 133
            |.|.:  .:..|.:| .....|.:..:.||:|||.  ........::|::.|:.|| |..|:
Mouse   135 WLRRH--AIPDDKLTYGTIAAIGEQNEERLRRLLARPTGGPGGAAQRKVRAFFRSC-LDMRE--- 193

  Fly   134 YKLALENVIREYGTLPALV------------------GAQWNSSDFSWWRTVAQIQHKYGKQIII 180
                    |...|..|.|.                  .|:|:.:     |.:.:.|..|....:.
Mouse   194 --------IERLGPRPMLEVIEDCGGWDLGGAADRPGAARWDLN-----RLLYKAQGVYSAAALF 245

  Fly   181 GLEIMHDIRNTS--VNRV------------YISQPD--------FKTINTRLTNLMEEVRTSMDL 223
            .|.:..|.||:|  |.|:            |::|.:        ::....||..|:.........
Mouse   246 SLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEESEKILAAYRVFMQRLLRLLGADAVEQKA 310

  Fly   224 QQYFGLSSSVAKHTAEQLTELERTFSSGGSGAATLQESLSLYTVADLQEKYSDHLNFTEFLGLIL 288
            |:...|...:|..:..:..:|.|..||          :.:..|:..|| |...||.:...|..|.
Mouse   311 QEILQLEQRLANISVSEYDDLRRDVSS----------AYNKVTLGQLQ-KIIPHLQWKWLLDQIF 364

  Fly   289 GEE-NIPKSLYIYDEEYLDKALLTMRSTPLATQANYVLWK-------------------LLEDFL 333
            .|: :..:.:.:...:|:.:....:||||.....||::|:                   |.::..
Mouse   365 QEDFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSSPFREALHELAKEME 429

  Fly   334 VDAQPKDMVKWCTESTKKYFGKLAEHAVYKRYRNPDVESEVHKIWDQIKGIFRQRLLGDKLDWIS 398
            .:.:|:::.:.|.....::||..........:.:...:::|.::.:.||.|..|||  ::|||:.
Mouse   430 GNDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRL--EELDWMD 492

  Fly   399 NATRTLAIEKLERMHLNINSYD----EENFENVYGEVFIDRLNYVSNVQQLLIAKGIRF-----V 454
            ..|:..|..||:.|.:.:...|    .|..:..| |..:....|..|     |...|||     |
Mouse   493 AQTKAAARAKLQYMMVMVGYPDFLLKPEAVDKEY-EFEVHEKTYFKN-----ILNSIRFSIQLSV 551

  Fly   455 ARINQPADSVDATELL---GFTPAYNIQENNITIPVALLQPRYFWGDQYPEALKYATLGYLLAHE 516
            .:|.|..|.  ::.||   .....|...:|.:..|..:|||..:..| :|::|.|..:|.::.||
Mouse   552 KKIRQEVDK--SSWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPD-FPQSLNYGGIGTIIGHE 613

  Fly   517 MLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSKLPESKDQSENIADSG 581
            :.||:||.|.|||.||||..||...|...|..:.:|....|..:.....::.......|||||.|
Mouse   614 LTHGYDDWGGQYDRSGNLLHWWTETSYSHFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMG 678

  Fly   582 GLKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQFLFQPWVSQS----- 641
            ||||||.||:.|:.:...|    ..:..|.:...||||:.:||..|...:       |||
Mouse   679 GLKLAYYAYQKWVREHGPE----HPLHRLKYTHNQLFFIAFAQNWCIKRR-------SQSIYLQV 732

  Fly   642 --DRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
              |:|||..|||:|.:|.|:||...|:|.:.:||:|.:||:::
Mouse   733 LTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	182/709 (26%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	180/702 (26%)
Ecel1	NP_001264854.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..52
Ecel1	NP_001264854.1	M13	121..773	CDD:341056	181/703 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841102
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840