Protein Alignment Nepl18 and Nep1

DIOPT Version :10

• Sequence 1: NP_651643.1
• Gene: Nepl18 / 43410
• FlyBaseID: FBgn0039611
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: XP_553645.4
• Gene: Nep1 / 1279203
• VectorBaseID: AGAMI1_011171
• Length: 869
• Species: Anopheles gambiae
• Alignment Length: 746
• Identity: 203/746 - (27%)
• Similarity: 332/746 - (44%)
• Gaps: 105/746 - (14%)

  Fly    11 LLVAIVPAM----AKPSDAGDPFA---DDLTSDYAKKIIV------QAKVAEMKTMMKPEVSPCD 62
            |||.:|...    .|...:.||||   .|:|.:..:...:      ....:.:...|.....||.
Mosquito   155 LLVYLVGRYRQLDGKSGCSADPFAPGCPDVTDESRRSSNICLTDECVRTASSLLAAMDRTADPCK 219

  Fly    63 DFYTHACGNWHRHN--PAQLLG----DVMTDNFKLISKGFDRRLQRLLRANDLQSELEKKMQRFY 121
            ||:..|||.|::.:  |.....    :|:.|..:.|.||.   |:..:...|  :...||.:.||
Mosquito   220 DFFQFACGTWNKMHVIPEDRSSISTFEVLADQQQAILKGV---LEEPVNKED--NRATKKAKAFY 279

  Fly   122 MSC-NL--VHRDDVHYKLALENVIREYGTLPALVGAQWNSSDFSWWRTVAQIQHKYGKQIIIGLE 183
            .|| ||  :...||.   ||...:::.|..| ::...|.....|....:.::..:|.:..::.|.
Mosquito   280 KSCMNLEQIRLLDVQ---ALRKSLKKLGGWP-VIEKNWTVPSTSIEHLLGKLTGEYDEPGLVELY 340

  Fly   184 IMHDIRNTSVNRVYISQPDFKTINTRLTNLMEEVRTSMDLQQY----------FGLSSSVAKHTA 238
            :..|.:|:|:|.:.:.|. ...:.:|...|.|.  :..|::.|          .|.....|....
Mosquito   341 VGADDKNSSMNIIQVDQL-LLALPSRDYYLKES--SEGDMKAYHRYMTQIAILMGADKDKAAEEL 402

  Fly   239 EQLTELERTFSSGGSGAATLQESLSLYTVADLQE--KYSDHLNFTEFLGLILGEENI--PKSLYI 299
            :::.|.|...::.....|...::.::||...|.|  :....:|:.|:|...||...:  .:|:..
Mosquito   403 QRIVEFEVRLANATLPEADRHDTSAIYTKITLPELQRRVPQINWKEYLQTTLGTVALHPNESIVS 467

  Fly   300 YDEEYLDKALLTMRSTPLATQANYVLWKLLEDF---LVDAQPKDMV--------------KW--C 345
            |...||.:....:|.|......||.:|:|:...   ::|...|:.|              :|  |
Mosquito   468 YAMPYLVELGKILRDTDRRIVHNYAIWRLVMSIMTHMIDDYQKERVEFRRKLLGIQSERNRWSQC 532

  Fly   346 TESTKKYFGKLAEHAVYKRYRNPDVESE------VHKIWDQIKGIFRQRLLGDKLDWISNATRTL 404
            .|.|.|..| :|..|::.| .|.:.||:      :|.|.:..     ..||.| :||:.:.||.:
Mosquito   533 VEWTNKKLG-MAVGALFIR-DNFNQESKETALTMIHTIREAF-----NELLAD-IDWMDDETRAV 589

  Fly   405 AIEKLERMHLNINSYD--------EENFEN--VYGEVFIDRLNYVSNVQQLLIAKGIRFVARINQ 459
            |.||.:.|:..|...|        |:.:.|  ::|.:|::      |:..:|..:..|.:..:.:
Mosquito   590 AKEKADAMNERIGYPDILTNADELEKEYVNLTIHGGLFLE------NILSILKWEAERNLQLLRK 648

  Fly   460 PADSVD-ATELLGFTPAYNIQENNITIPVALLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDD 523
            |.|... |||.......||..:|:|..|..:||| .|:...:|::|.|..:|.::.||:.|||||
Mosquito   649 PVDKNKWATEPAVVNAFYNPNKNDIVFPAGILQP-LFYSQNFPKSLNYGGIGVVIGHEITHGFDD 712

  Fly   524 DGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYG--GSKLPESKDQSENIADSGGLKLA 586
            .|||:|..||:..||:..:...|.||.:|...||..|:..  |..:.....|.|||||:||||.:
Mosquito   713 KGRQFDKDGNMMQWWNNATIKTFRERAQCIIDQYSRYKIDEVGLYMDGRMTQGENIADNGGLKQS 777

  Fly   587 YAAYELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQFLFQPWVSQSDRHAPSKYRV 651
            |.||..|:.|...|    ..:.||.....|||||.|||:.|..::........:|..|:|...||
Mosquito   778 YRAYRKWVSQHGSE----PDLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSSVHSPGIIRV 838

  Fly   652 IGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
            ||||||.::|...:.|...:||:|..||:::
Mosquito   839 IGPLSNSRDFAEAYRCPLGSPMNPVSKCSVW 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	M13	58..679	CDD:341056	189/681 (28%)
Nep1	XP_553645.4	None