DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl18 and Gm49333

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_808810.1	Gene:	Gm49333 / 110599584	MGIID:	6121518	Length:	910	Species:	Mus musculus

Alignment Length:	703	Identity:	186/703 - (26%)
Similarity:	310/703 - (44%)	Gaps:	98/703 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 IIVQAKVAEMKTMMKPEVSPCDDFYTHACGNWHRHNPAQLLGDVMTDNFKLISKGFDRRLQRLLR 105
            |.|..|:.|   .:...||||.|||..:||.|.|.||.. .|....:.|..:.......|:.||.
Mouse   245 IRVAGKILE---SLDRGVSPCQDFYQFSCGGWIRRNPLP-NGRSRWNTFNSLWDQNQAILKHLLE 305

  Fly   106 AN--DLQSELEKKMQRFYMSCNLVHRDDVHYKLALENVIREYGTLPALVGAQWNSS----DFSWW 164
            ..  :..||.|:|.:.||:||....|.:......|.::|.:.|        .||.:    :.|:.
Mouse   306 NTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLRDLIDKIG--------GWNITGPWDEDSFM 362

  Fly   165 RTVAQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQ-----PDFKTINTRLTNLMEEVRTS---- 220
            ..:..:...|.......:.:..|.::::.|.:.:.|     |.......|..|  |:|.|:
Mouse   363 DVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFLPSRDYYLNRTAN--EKVLTAYLDY 425

  Fly   221 -MDLQQYFGLSSSVAKHTAEQLTELERTFSSGGSGAATLQESLSLY---TVADLQEKYSDHLNFT 281
             ::|....|...:..:...:|:.|||...::........::...:|   ::::|| ..:..:::.
Mouse   426 MVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ-ALAPAVDWL 489

  Fly   282 EFLGLILGEENIPKS--LYIYDEEYLDKALLTMRSTPLATQANYVLWKL-------LEDFLVDAQ 337
            |||..:|....:..|  :.:|..|||.:....:..|..:...||::|.|       |:.....||
Mouse   490 EFLSFLLSPLELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQ 554

  Fly   338 PKDM-----------VKW--CTESTKK----YFGKLAEHAVYKRYRNPDVESEVHKIWDQIKGIF 385
            .|.:           .:|  |..:|..    ..|.|...|.:.|......|..:    ::|:..|
Mouse   555 EKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMI----NEIRSAF 615

  Fly   386 RQRLLGDKLDWISNATRTLAIEKLERMHLNINSYD----EENFENVYGEVFIDRLNYVSNVQQLL 446
             :..||| |.|:...||..|.||.:.::..|...|    .:..::||....:...::..|:..|
Mouse   616 -EETLGD-LVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNL- 677

  Fly   447 IAKGIRFVARINQPADSV---DATELLGFTP----AYNI-QENNITIPVALLQPRYFWGDQYPEA 503
                ..|.|::  .||.:   .:.:....||    ||.: .:|.|..|..:||.. |:...:|:|
Mouse   678 ----YNFSAKV--MADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAP-FYAHNHPKA 735

  Fly   504 LKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSKLP 568
            |.:..:|.::.||:.|.|||.||:||..|||.|||..:|...|:....|.:.||.:||..|.:|.
Mouse   736 LNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLN 800

  Fly   569 ESKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQFL 633
            ..:...|||||:||||.||.||:.||.:..||    :.:..:...:.||||:|:||:.|.    :
Mouse   801 GLQTLGENIADNGGLKAAYNAYKAWLRKHGEE----QPLPAVGLTNHQLFFVGFAQVWCS----V 857

  Fly   634 FQPWVSQ----SDRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
            ..|..|.    :|.|:|:::||:|.|||.::|...|.|...:||:|...|.::
Mouse   858 RTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	182/688 (26%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	181/681 (27%)
Gm49333	NP_808810.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	248..901	CDD:226118	180/689 (26%)
		M13	259..908	CDD:189000	181/682 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841084
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850