Protein Alignment Nepl18 and Ece2

DIOPT Version :10

• Sequence 1: NP_651643.1
• Gene: Nepl18 / 43410
• FlyBaseID: FBgn0039611
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_647454.2
• Gene: Ece2 / 107522
• MGIID: 1101356
• Length: 763
• Species: Mus musculus
• Alignment Length: 703
• Identity: 186/703 - (26%)
• Similarity: 310/703 - (44%)
• Gaps: 98/703 - (13%)

  Fly    41 IIVQAKVAEMKTMMKPEVSPCDDFYTHACGNWHRHNPAQLLGDVMTDNFKLISKGFDRRLQRLLR 105
            |.|..|:.|   .:...||||.|||..:||.|.|.||.. .|....:.|..:.......|:.||.
Mouse    98 IRVAGKILE---SLDRGVSPCQDFYQFSCGGWIRRNPLP-NGRSRWNTFNSLWDQNQAILKHLLE 158

  Fly   106 AN--DLQSELEKKMQRFYMSCNLVHRDDVHYKLALENVIREYGTLPALVGAQWNSS----DFSWW 164
            ..  :..||.|:|.:.||:||....|.:......|.::|.:.|        .||.:    :.|:.
Mouse   159 NTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLRDLIDKIG--------GWNITGPWDEDSFM 215

  Fly   165 RTVAQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQ-----PDFKTINTRLTNLMEEVRTS---- 220
            ..:..:...|.......:.:..|.::::.|.:.:.|     |.......|..|  |:|.|:
Mouse   216 DVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFLPSRDYYLNRTAN--EKVLTAYLDY 278

  Fly   221 -MDLQQYFGLSSSVAKHTAEQLTELERTFSSGGSGAATLQESLSLY---TVADLQEKYSDHLNFT 281
             ::|....|...:..:...:|:.|||...::........::...:|   ::::|| ..:..:::.
Mouse   279 MVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ-ALAPAVDWL 342

  Fly   282 EFLGLILGEENIPKS--LYIYDEEYLDKALLTMRSTPLATQANYVLWKL-------LEDFLVDAQ 337
            |||..:|....:..|  :.:|..|||.:....:..|..:...||::|.|       |:.....||
Mouse   343 EFLSFLLSPLELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQ 407

  Fly   338 PKDM-----------VKW--CTESTKK----YFGKLAEHAVYKRYRNPDVESEVHKIWDQIKGIF 385
            .|.:           .:|  |..:|..    ..|.|...|.:.|......|..:    ::|:..|
Mouse   408 EKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMI----NEIRSAF 468

  Fly   386 RQRLLGDKLDWISNATRTLAIEKLERMHLNINSYD----EENFENVYGEVFIDRLNYVSNVQQLL 446
             :..||| |.|:...||..|.||.:.::..|...|    .:..::||....:...::..|:..|
Mouse   469 -EETLGD-LVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNL- 530

  Fly   447 IAKGIRFVARINQPADSV---DATELLGFTP----AYNI-QENNITIPVALLQPRYFWGDQYPEA 503
                ..|.|::  .||.:   .:.:....||    ||.: .:|.|..|..:||.. |:...:|:|
Mouse   531 ----YNFSAKV--MADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAP-FYAHNHPKA 588

  Fly   504 LKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSKLP 568
            |.:..:|.::.||:.|.|||.||:||..|||.|||..:|...|:....|.:.||.:||..|.:|.
Mouse   589 LNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLN 653

  Fly   569 ESKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQFL 633
            ..:...|||||:||||.||.||:.||.:..||    :.:..:...:.||||:|:||:.|.    :
Mouse   654 GLQTLGENIADNGGLKAAYNAYKAWLRKHGEE----QPLPAVGLTNHQLFFVGFAQVWCS----V 710

  Fly   634 FQPWVSQ----SDRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
            ..|..|.    :|.|:|:::||:|.|||.::|...|.|...:||:|...|.::
Mouse   711 RTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	M13	58..679	CDD:341056	181/681 (27%)
Ece2	NP_647454.2	M13	112..761	CDD:341056	181/682 (27%)