DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and mme

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_031758820.1	Gene:	mme / 101734885	XenbaseID:	XB-GENE-1011098	Length:	746	Species:	Xenopus tropicalis

Alignment Length:	789	Identity:	200/789 - (25%)
Similarity:	338/789 - (42%)	Gaps:	184/789 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LCLL-----VAIVPAMAKPSDAGDPFADDLTS----DYAKKIIVQAKVAEMKTMMKPEVSPCDDF 64
            ||:.     :|::.|.|..:|.      ..||    ..|.:||..         |.....||:||
Frog    27 LCIFLGIISIAMILAYATSNDG------ICTSQACISTAARIIAN---------MDAATDPCNDF 76

  Fly    65 YTHACGNWHRHNPAQLLGDVMTDNFKLISKGFDRRLQRLLRAN---DLQSELE----------KK 116
            |.:|||.|.:.|.       :.|| .::|..||     :||.:   .|:..||          ||
Frog    77 YQYACGGWLKKNR-------IPDN-NIVSNTFD-----ILRTDIEVVLKDALEKESADDIPAIKK 128

  Fly   117 MQRFYMSCNLVHRDDVHYKLALENVIREYG----TLPALVGAQWNSSDFSW-------W---RTV 167
            ::.||.||    .|:     .::| :|:.|    |||||.  .|..:..:|       |   .::
Frog   129 VKTFYKSC----IDE-----TIKN-LRKGGPLIKTLPALY--DWPIAVDNWETRYGLVWSAQESI 181

  Fly   168 AQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQP----------DFK-TINTRLTNLMEE-VRTS 220
            |....|||:..:|.:.:..|:.|:|...::|.||          |.| |........||: |..:
Frog   182 AGFITKYGQSGLINVYVSEDLTNSSTYILHIDQPGLGLPSKDYYDCKGTSEIACLAYMEQMVSVA 246

  Fly   221 MDLQQYFGLSSSVAKHTAEQLTELERTFS-----SGGSGAATLQESLS-LY---TVADLQEKY-- 274
            |.:::...|:.:..|    .|:|:|:.|.     :....:..::|:|: :|   |::.:.:.|
Frog   247 MLIRKERNLTINEDK----ILSEMEKVFKLEREIAKAEASEEIRENLNDIYKKMTLSGIAKTYPL 307

  Fly   275 ---SDHLNFTEFLGLILG------EENIPKSLYIYDEEYLDKALLTMRSTPLATQANYVLWKLLE 330
               ..::|:.:.:..|:.      |||...:|...|  || |.|..:.........||:.|:.:.
Frog   308 KMNDQNINWLKLINAIISPGGVSIEENEQVALICSD--YL-KKLRFLNKYKARELQNYLGWRYIL 369

  Fly   331 DFLVD--------------------AQPKDMVKWCTESTKKYFGKLAEHAVYKRYRNPDVESEVH 375
            ..:.|                    |:..|   |.|..|  |.....|.|:.:.|....:.:::.
Frog   370 SAINDLSLEYKNTGIHLKKALYGNAAEGSD---WQTCVT--YLNDNMEDAIGRLYLKETLSADIE 429

  Fly   376 --KIWDQIKGI---FRQRLLG--DKLDWISNATRTLAIEKL----ERMHLNINSYDEENFENVYG 429
              |:.|::|.|   .|:..|.  :::||:...|:..|..|:    ||:..:.:..|:......|.
Frog   430 HVKVKDKVKEIIAEIRRAFLEMLEEMDWMDEDTKKRAARKVASINERIAFSEDIMDDFKLNEGYS 494

  Fly   430 -------EVFIDRLNYVSNVQQLLIAKGIRFVARINQ------PADSVDATELLGFTPAYNIQEN 481
                   |:|.::..|:..||:.:.:   |...::|:      || .|:|        .|::..|
Frog   495 ELEFRVDELFENKQKYIEFVQKKMTS---RLRKQVNKNEWVPGPA-HVNA--------FYSLTYN 547

  Fly   482 NITIPVALLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEF 546
            .|..|..:||..:|...| |.||.|..:|.::.||:.||||:.|..:|..|||..||...|...|
Frog   548 EIVFPAGILQTPFFSSSQ-PSALNYGGIGMIIGHEITHGFDNRGCNFDEHGNLVNWWTNASMMNF 611

  Fly   547 EERRKCFQAQYHEYQY---GGSKLPESKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQRETME 608
            ....:||..||..|.:   ||..|.......|||:|:||::.||.|::.::....|:    :.:.
Frog   612 SNLSQCFVNQYGNYSWDEAGGQYLNGISTLGENISDNGGIRGAYRAFKNYVKSHKED----DLLP 672

  Fly   609 GLPFNSRQLFFLGYAQLLCDDVQFLFQPWVSQSDRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPM 673
            |:..:|.||||:.:.|:.|...:..:...:.::..|.|..:||||.|.|..||...|:|..:|.|
Frog   673 GIDLDSDQLFFISFGQIWCGMHRPEYAATLIKTGSHTPGIFRVIGTLQNSPEFSKAFSCCNNAYM 737

  Fly   674 DPEYKCAIY 682
            :|..||.::
Frog   738 NPAVKCKLW 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	189/733 (26%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	186/726 (26%)
mme	XP_031758820.1	M13	71..744	CDD:341056	187/726 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020