Protein Alignment Nepl18 and ecel1

DIOPT Version :10

• Sequence 1: NP_651643.1
• Gene: Nepl18 / 43410
• FlyBaseID: FBgn0039611
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: XP_012818808.2
• Gene: ecel1 / 100496473
• XenbaseID: XB-GENE-989944
• Length: 764
• Species: Xenopus tropicalis
• Alignment Length: 716
• Identity: 203/716 - (28%)
• Similarity: 319/716 - (44%)
• Gaps: 127/716 - (17%)

  Fly    49 EMKTMMK----------PEVSPCDDFYTHACGNW-HRHN-PAQLLGDVMTDNFKLISKGFDRRLQ 101
            |.|..|:          |.:|||.|||:.|||.| .||. |...|   :......|.:..:.:|:
 Frog    94 ERKAFMRASKFITNNIDPTISPCTDFYSFACGGWLRRHGIPEDKL---IYGTIAAIGEQNEEKLE 155

  Fly   102 RLLRANDLQ-------SELEKKMQRFYMSC-NLVHRDDVHYKLALENVIREYG--TLPALVGAQW 156
            .||    ||       ...|:|::.|:.|| |:...|.:..:..|: ||.:.|  .||.....||
 Frog   156 HLL----LQPVRRKHKGSAERKVKEFFKSCLNMRDIDRLGARPMLQ-VIEDCGGWDLPEDPRTQW 215

  Fly   157 NSSDFSWWRTVAQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQPDFKTINTRLTNLMEEVRTSM 221
            :.::..:     :.|..|...:...:.:..|.:|:|...:.|.| |..|:..|...|.::..:..
 Frog   216 DFNELLY-----KTQGVYSTAVFFSMTVSLDDKNSSRYIIRIDQ-DGLTLPERTLYLGQDEESIK 274

  Fly   222 DLQQY----------FGLSSSVAKHTAEQLTELER-----TFSSGGSGAATLQESLSLYTVADLQ 271
            .|:.|          .|:.:...|  ||::..||:     |.|........:....:..|:|.||
 Frog   275 VLEAYKVFMQTILSLLGVENVQKK--AEEILHLEQHLSNITISEFDDMRRDISTMYNKVTLAQLQ 337

  Fly   272 EKYSDHLNFTEFLGLILGEENIPKSLYIYDEE-------YLDKALLTMRSTPLATQANYVLWKL- 328
            : .:.|||:...|..|. ..|.|:     |||       |:.|....:||||.:...||:||::
 Frog   338 Q-ITPHLNWKNLLNRIF-HTNFPE-----DEEVVVLATDYMQKVSEMIRSTPASVLHNYMLWRIV 395

  Fly   329 --LEDFLV----DA------------QPKDMVKWCTESTKKYFGKLAEHAVYKRYRNPDVESEVH 375
              |.:.|.    ||            :..::.|.|.....|:||........:.|.:...:::|.
 Frog   396 VVLSEHLSTPFRDAIHELSKEMEGSEKQAELTKVCLTQANKHFGMALGALFVEEYFSSSSKAKVQ 460

  Fly   376 KIWDQIKGIFRQRLLGDKLDWISNATRTLAIEKLERMHLNINSYD----EENFENVYGEVFIDRL 436
            ::.:.||.|...||  ::|||:...|:..|.|||:.|.:.|...|    .|:.:..| |..::..
 Frog   461 QLVENIKHILDYRL--EELDWMDTETKQAAREKLKHMMVMIGYPDVLLQPESMDKEY-EFEVNEK 522

  Fly   437 NYVSNVQQLLIAKGIRF-----VARINQPADSVDATELL---GFTPAYNIQENNITIPVALLQPR 493
            .|..|     |...||:     |.||.|..|.  :..||   .....|...:|.:..|..:|||.
 Frog   523 TYFKN-----ILNSIRYSIKMAVRRIRQEVDK--SAWLLPPQALNAYYLPNKNQMVFPAGILQPT 580

  Fly   494 YFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYH 558
            .:..| :|::|.|..:|.::.||:.||:||.|.||||:||...||...|..:|.::.:|....|.
 Frog   581 LYDPD-FPQSLNYGGIGTIIGHELTHGYDDWGGQYDANGNPIQWWTEDSYSKFLKKAECIVDLYE 644

  Fly   559 EYQYGGSKLPESKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYA 623
            .:.....::.......|||||.|||||||.||:.|:.....|    ..:..|.:...||||:.:|
 Frog   645 NFTVYNQRVNGRTTLGENIADLGGLKLAYYAYQKWVRDNGPE----RPLPRLKYTHDQLFFIAFA 705

  Fly   624 QLLCDDVQFLFQPWVSQS-------DRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAI 681
            |..|...:       |||       |:|||..|||:|.:|.|:||..||:|.:::||:|.:||::
 Frog   706 QNWCIKRR-------SQSIYLQVLTDKHAPEHYRVMGSVSQFEEFGRVFHCPRNSPMNPVHKCSV 763

  Fly   682 Y 682
            :
 Frog   764 W 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	M13	58..679	CDD:341056	197/692 (28%)
ecel1	XP_012818808.2	M13	113..762	CDD:341056	198/693 (29%)