DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and ecel1

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_012818808.2	Gene:	ecel1 / 100496473	XenbaseID:	XB-GENE-989944	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	716	Identity:	203/716 - (28%)
Similarity:	319/716 - (44%)	Gaps:	127/716 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 EMKTMMK----------PEVSPCDDFYTHACGNW-HRHN-PAQLLGDVMTDNFKLISKGFDRRLQ 101
            |.|..|:          |.:|||.|||:.|||.| .||. |...|   :......|.:..:.:|:
Frog    94 ERKAFMRASKFITNNIDPTISPCTDFYSFACGGWLRRHGIPEDKL---IYGTIAAIGEQNEEKLE 155

  Fly   102 RLLRANDLQ-------SELEKKMQRFYMSC-NLVHRDDVHYKLALENVIREYG--TLPALVGAQW 156
            .||    ||       ...|:|::.|:.|| |:...|.:..:..|: ||.:.|  .||.....||
Frog   156 HLL----LQPVRRKHKGSAERKVKEFFKSCLNMRDIDRLGARPMLQ-VIEDCGGWDLPEDPRTQW 215

  Fly   157 NSSDFSWWRTVAQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQPDFKTINTRLTNLMEEVRTSM 221
            :.::..:     :.|..|...:...:.:..|.:|:|...:.|.| |..|:..|...|.::..:..
Frog   216 DFNELLY-----KTQGVYSTAVFFSMTVSLDDKNSSRYIIRIDQ-DGLTLPERTLYLGQDEESIK 274

  Fly   222 DLQQY----------FGLSSSVAKHTAEQLTELER-----TFSSGGSGAATLQESLSLYTVADLQ 271
            .|:.|          .|:.:...|  ||::..||:     |.|........:....:..|:|.||
Frog   275 VLEAYKVFMQTILSLLGVENVQKK--AEEILHLEQHLSNITISEFDDMRRDISTMYNKVTLAQLQ 337

  Fly   272 EKYSDHLNFTEFLGLILGEENIPKSLYIYDEE-------YLDKALLTMRSTPLATQANYVLWKL- 328
            : .:.|||:...|..|. ..|.|:     |||       |:.|....:||||.:...||:||::
Frog   338 Q-ITPHLNWKNLLNRIF-HTNFPE-----DEEVVVLATDYMQKVSEMIRSTPASVLHNYMLWRIV 395

  Fly   329 --LEDFLV----DA------------QPKDMVKWCTESTKKYFGKLAEHAVYKRYRNPDVESEVH 375
              |.:.|.    ||            :..::.|.|.....|:||........:.|.:...:::|.
Frog   396 VVLSEHLSTPFRDAIHELSKEMEGSEKQAELTKVCLTQANKHFGMALGALFVEEYFSSSSKAKVQ 460

  Fly   376 KIWDQIKGIFRQRLLGDKLDWISNATRTLAIEKLERMHLNINSYD----EENFENVYGEVFIDRL 436
            ::.:.||.|...||  ::|||:...|:..|.|||:.|.:.|...|    .|:.:..| |..::..
Frog   461 QLVENIKHILDYRL--EELDWMDTETKQAAREKLKHMMVMIGYPDVLLQPESMDKEY-EFEVNEK 522

  Fly   437 NYVSNVQQLLIAKGIRF-----VARINQPADSVDATELL---GFTPAYNIQENNITIPVALLQPR 493
            .|..|     |...||:     |.||.|..|.  :..||   .....|...:|.:..|..:|||.
Frog   523 TYFKN-----ILNSIRYSIKMAVRRIRQEVDK--SAWLLPPQALNAYYLPNKNQMVFPAGILQPT 580

  Fly   494 YFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYH 558
            .:..| :|::|.|..:|.::.||:.||:||.|.||||:||...||...|..:|.::.:|....|.
Frog   581 LYDPD-FPQSLNYGGIGTIIGHELTHGYDDWGGQYDANGNPIQWWTEDSYSKFLKKAECIVDLYE 644

  Fly   559 EYQYGGSKLPESKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYA 623
            .:.....::.......|||||.|||||||.||:.|:.....|    ..:..|.:...||||:.:|
Frog   645 NFTVYNQRVNGRTTLGENIADLGGLKLAYYAYQKWVRDNGPE----RPLPRLKYTHDQLFFIAFA 705

  Fly   624 QLLCDDVQFLFQPWVSQS-------DRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAI 681
            |..|...:       |||       |:|||..|||:|.:|.|:||..||:|.:::||:|.:||::
Frog   706 QNWCIKRR-------SQSIYLQVLTDKHAPEHYRVMGSVSQFEEFGRVFHCPRNSPMNPVHKCSV 763

  Fly   682 Y 682
            :
Frog   764 W 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	201/709 (28%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	197/692 (28%)
ecel1	XP_012818808.2	M13	113..762	CDD:341056	198/693 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020