DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and LOC100332538

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_021322193.1	Gene:	LOC100332538 / 100332538	-ID:	-	Length:	808	Species:	Danio rerio

Alignment Length:	791	Identity:	202/791 - (25%)
Similarity:	322/791 - (40%)	Gaps:	186/791 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LCLLVAIVPA----------------MAKPSDAGDPFADDLTSDYAKKIIVQAKVAEMKTMMKPE 57
            :|||.|:|.|                 |:..|:      ....|..|:..:......::..:.|.
Zfish    87 ICLLSALVFAAGMCVILGCMLALKFLXARSQDS------QCRQDCVKRRSLLRAARFVQGNIDPS 145

  Fly    58 VSPCDDFYTHACGNW-HRHN-PAQLLG-DVMTDNFKLISKGFDRRLQRLLRANDLQSEL---EKK 116
            |.||.|||:.|||.| .||. |...|. .::|    .|.:....:|||||:|...:.||   |:|
Zfish   146 VQPCHDFYSFACGGWLRRHGIPEDKLSYGIIT----AIGEQNQDKLQRLLQAPVQRRELESAERK 206

  Fly   117 MQRFYMSCNLVHRDDVHYKLALENVIRE------YGTLPALVGAQWNSS------DFSWWRTVAQ 169
            ::.||.||..:...|......:..||..      .|..|.  ||.|:|.      ||:  ..:.:
Zfish   207 VKEFYRSCINIKEIDRLGAGPMTEVIDSCGGWDLSGAPPG--GAGWDSGSAPIRPDFN--EMLYK 267

  Fly   170 IQHKYGKQIIIGLEIMHDIRNTSVNRVYISQPDFKTINTRLTNLMEEVRTSMDLQQYFGLSSSVA 234
            .|..|...:...|.:..|.:|:|.|.:.|.|               |..|..:...|.|......
Zfish   268 TQGVYSTSVFFSLTVSVDDKNSSRNAIRIDQ---------------EGLTLPERTLYLGQDEDSV 317

  Fly   235 KHTAEQLTELERTFSSGGSGAAT--------LQESLSLYTVADLQEKYSD--------------- 276
            |..|.....:||..|..|:..||        |:..|:..||::.:::..|
Zfish   318 KILASYKALMERLLSMLGAHNATLKSREILDLETKLANITVSEYEDQRKDISSMYNRITLKQLQK 382

  Fly   277 ---------------HLNFTEFLGLILGEENIPKSLYIYDEEYLDKALLTMRSTPLATQANYVLW 326
                           :.||:|       ||.|    .:...:|:......:::|......||:||
Zfish   383 MAPSFHWKRLLDRIFNDNFSE-------EEEI----VVLATDYMQTVSDIIKTTSKRVLHNYMLW 436

  Fly   327 KL---LEDFLVDA----------------QPKDMVKWCTESTKKYFGKLAEHAVYKRYRNPDVES 372
            ::   |.:.|..|                |..|:.:.|.....|:||........:::.:....:
Zfish   437 RMVAALSEHLSTAFRSTIHEFSREIDGTEQQLDLERLCLTQANKHFGMALGALFVQQHFSSSSRA 501

  Fly   373 EVHKIWDQIKGIFRQRLLGDKLDWISNATRTLAIEKLERMHLNINSY----------DEE-NFEN 426
            :|.::.:.||.....||  .:|||:...|:..|..||:.| :.:..|          ||| .|:
Zfish   502 KVQELVEDIKHSLDVRL--QELDWMDEETKDAARGKLQHM-MVMTGYPDFLLKPELIDEEYAFD- 562

  Fly   427 VYGEVFIDRLNYVSNVQQLLIAKGIRF-----VARINQPADSVDATELL---GFTPAYNIQENNI 483
                  ::...|..|     |...|::     :.:|::..|.  .|.||   .....|...:|.:
Zfish   563 ------VNEKTYFKN-----ILNSIKYNIKLSIKKIHKEVDK--TTWLLPPQALNAYYLPNKNQM 614

  Fly   484 TIPVALLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEE 548
            ..|..:|||. .:..::|::|.|..:|.::.||:.||:||.|.|||..|||..||..:|..:|::
Zfish   615 VFPAGILQPT-LYDPEFPQSLNYGGIGAIIGHELTHGYDDWGGQYDRYGNLKQWWTEESYRKFQK 678

  Fly   549 RRKCFQAQYHEYQYGGSKLPESKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQRETMEGLPFN 613
            :.:|....|..:.....::.......|||||.|||||:|.||:.|:.:...|    ..:.||...
Zfish   679 KTECIVKLYDNFTVYNQRVNGRLTLGENIADLGGLKLSYHAYQKWVREHGPE----RPLPGLKHT 739

  Fly   614 SRQLFFLGYAQLLCDD-------VQFLFQPWVSQSDRHAPSKYRVIGPLSNFQEFPWVFNCSQSA 671
            ..||||:.:||..|..       :|.|       :|:|||..|||||.:|.|:||..||:|.:.:
Zfish   740 HEQLFFIAFAQNWCMKRRSQSIYLQLL-------TDKHAPEHYRVIGSVSQFEEFGRVFHCPRGS 797

  Fly   672 PMDPEYKCAIY 682
            ||:|..||:::
Zfish   798 PMNPVNKCSVW 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	192/728 (26%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	189/721 (26%)
LOC100332538	XP_021322193.1	M13	146..806	CDD:189000	190/722 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585591
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850