Protein Alignment Nepl17 and ECE2

DIOPT Version :10

• Sequence 1: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001093590.1
• Gene: ECE2 / 9718
• HGNCID: 13275
• Length: 811
• Species: Homo sapiens
• Alignment Length: 740
• Identity: 180/740 - (24%)
• Similarity: 312/740 - (42%)
• Gaps: 98/740 - (13%)

  Fly     1 MERLPASACLIFVTLAVGSLAIQGGVF---KELTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFY 62
            :|.:.|.|.|:...|.:|.|...|..:   ...:|.|.:..:|:|  .::...:|..||||:|||
Human   105 LELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVA--GKILESLDRGVSPCEDFY 167

  Fly    63 GYACGNYA-------------TINAATSQKDTNIRQLMFANYLRRVRQVLNEPRISTDRPMEVRV 114
            .::||.:.             |.|:...|....::.|            |.....::....|.:.
Human   168 QFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHL------------LENTTFNSSSEAEQKT 220

  Fly   115 KYFYESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVGFDAIEMMAQLLRRYGKLTLLGV 179
            :.||.|||....:.......|..::.:.||. .:.| .||...|  :|::..:...|.......|
Human   221 QRFYLSCLQVERIEELGAQPLRDLIEKIGGW-NITG-PWDQDNF--MEVLKAVAGTYRATPFFTV 281

  Fly   180 YVVPDHFNSQIKRLQLGQR----------LDLAESDEFASLWKKYALKMRLRNLLGLSEELARKT 234
            |:..|..:|....:|:.|.          |:...:::..:.:..|..::.:  |||......|:.
Human   282 YISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGM--LLGGRPTSTREQ 344

  Fly   235 AEEIIELELELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLGSEYNL----P 295
            .::::|||::|:.........||...:.|...:|.: .|..|.::...|: |:|.|...|    |
Human   345 MQQVLELEIQLANITVPQDQRRDEEKIYHKMSISEL-QALAPSMDWLEFL-SFLLSPLELSDSEP 407

  Fly   296 VFESVPSYLFQVKKILLSTPNHVVANYML--------SSLLTDFEITANEEQQKVI--------- 343
            |......||.||.:::..|...::.||::        |||...||    ..|:|::
Human   408 VVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFE----SAQEKLLETLYGTKKS 468

  Fly   344 CHERITELFPDVVDHM--------VYHSLEQQNPYIANEMRSLWVELKSSFREMLSSPDIEWLEK 400
            |..|......:..|.:        |..:.::|:..||..|.|   |::::|.|.|.  .:.|:::
Human   469 CVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMIS---EIRTAFEEALG--QLVWMDE 528

  Fly   401 QTREELLEKLNGMSFEIAGG-----QAVNFEEQFGDLVVSSADYYGNIQRLLEVKARILRTDLLR 460
            :||:...||.:.: :::.|.     :....::.:....:|...::.|:..|....|::: .|.||
Human   529 KTRQAAKEKADAI-YDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVM-ADQLR 591

  Fly   461 E--SSSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFD 523
            :  |...:.....|....|....|.:|.|...:|..: :...:|.||.:|.:|..|.||:.|.||
Human   592 KPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPF-YARNHPKALNFGGIGVVMGHELTHAFD 655

  Fly   524 DLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQFSGMLYGNLRLRRLKSQAESIADNVGIRIAQ 588
            |..|.||..|||...|..::...|.....|:.:|::.......||...::..|:||||.|::.|.
Human   656 DQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAY 720

  Fly   589 SAYWKWLDQVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAM 653
            :||..||.  :..|.:.||.:..:..||||:..||..||...||.....:..:.|.|...||...
Human   721 NAYKAWLR--KHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGT 783

  Fly   654 MINSPAFAEAFQCSNSSKMNPPNKC 678
            :.||..|...|.|...|.|||...|
Human   784 LSNSRDFLRHFGCPVGSPMNPGQLC 808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	M13	55..678	CDD:341056	166/681 (24%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..64
		M13	160..809	CDD:341056	167/683 (24%)