DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl17 and ECEL1

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_004817.2	Gene:	ECEL1 / 9427	HGNCID:	3147	Length:	775	Species:	Homo sapiens

Alignment Length:	767	Identity:	176/767 - (22%)
Similarity:	303/767 - (39%)	Gaps:	152/767 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ASACLIFVTLA----VGSLAIQGGVFKELTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFYGYAC 66
            |..|.|...:.    :|.:|..||...| ..|..:...|.|:.  :.:.:|.|:.||.|||.:||
Human    70 AGLCAILAAMLALKYLGPVAAGGGACPE-GCPERKAFARAARF--LAANLDASIDPCQDFYSFAC 131

  Fly    67 G-------------NYATINAATSQKDTNIRQLMFANYLRRVRQVLNEPRISTDRPMEVRVKYFY 118
            |             .|.||.|...|.:            .|:|::|..|........:.:|:.|:
Human   132 GGWLRRHAIPDDKLTYGTIAAIGEQNE------------ERLRRLLARPGGGPGGAAQRKVRAFF 184

  Fly   119 ESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVG----------FDAIEMMAQLLRRYGK 173
            .||||...:.......:|.|:.:.||        ||..|          :|...::.:....|..
Human   185 RSCLDMREIERLGPRPMLEVIEDCGG--------WDLGGAEERPGVAARWDLNRLLYKAQGVYSA 241

  Fly   174 LTLLGVYVVPDHFNSQIKRLQLGQ--------RLDLAESDEFASLWKKYALKM-RLRNLLGLSEE 229
            ..|..:.|..|..||....:::.|        .|.||:.::...:...|.:.| |:.:|||  .:
Human   242 AALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEDSEKILAAYRVFMERVLSLLG--AD 304

  Fly   230 LARKTAEEIIELELELSR-SAFDH-RMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVT-SWLGSE 291
            ...:.|:||:::|.:|:. :..:| .:.||...|.:...|       |.:..:|..:. .||..:
Human   305 AVEQKAQEILQVEQQLANITVSEHDDLRRDVSSMYNKVTL-------GQLQKITPHLRWKWLLDQ 362

  Fly   292 YNLPVFES-----------VPSYLFQVKKILLSTPNHVVANYMLSSLLTDFEITANEEQQKVICH 345
                :|:.           ...|:.||.:::.|||:.|:.||::..::             |:..
Human   363 ----IFQEDFSEEEEVVLLATDYMQQVSQLIRSTPHRVLHNYLVWRVV-------------VVLS 410

  Fly   346 ERITELFPDVVDHMVYHSLE--------------QQNPYIANEMRSLWV-------------ELK 383
            |.::..|.:.: |.:...:|              |.|.:....:.:|:|             :|.
Human   411 EHLSPPFREAL-HELAQEMEGSDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLV 474

  Fly   384 SSFREMLSS--PDIEWLEKQTREELLEKLNGMSFEIA------GGQAVNFEEQFGDLVVSSADYY 440
            ...:.:|..  .:::|::.:||.....||..|...:.      ...||:.|.:|   .|....|:
Human   475 EDIKYILGQRLEELDWMDAETRAAARAKLQYMMVMVGYPDFLLKPDAVDKEYEF---EVHEKTYF 536

  Fly   441 GNIQRLLEVKARILRTDLLRE-SSSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAA 504
            .||...:....::....:.:| ..|.:..........|....|.:|.|...:|.. |:|..:|.:
Human   537 KNILNSIRFSIQLSVKKIRQEVDKSTWLLPPQALNAYYLPNKNQMVFPAGILQPT-LYDPDFPQS 600

  Fly   505 LKYGTLGFTMAHEMAHGFDDLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQFSGMLYGNLRLR 569
            |.||.:|..:.||:.||:||....||..|||...|:..:...|.....|:...:......|.|:.
Human   601 LNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLRKAECIVRLYDNFTVYNQRVN 665

  Fly   570 RLKSQAESIADNVGIRIAQSAYWKWLDQVEMEETESLPHMTQSPEQLFFLSAAQFMC-----SDI 629
            ...:..|:|||..|:::|..||.||:.:...|  ..||.:..:.:||||::.||..|     ..|
Human   666 GKHTLGENIADMGGLKLAYHAYQKWVREHGPE--HPLPRLKYTHDQLFFIAFAQNWCIKRRSQSI 728

  Fly   630 YPERRANFVRNNFHPPYEARVFAMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681
            |.:     |..:.|.|...||...:.....|..||.|...|.|||.:||.::
Human   729 YLQ-----VLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPAHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	160/709 (23%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	161/709 (23%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	162/710 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920