DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl17 and Ece1

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_006239337.1	Gene:	Ece1 / 94204	RGDID:	620293	Length:	769	Species:	Rattus norvegicus

Alignment Length:	730	Identity:	181/730 - (24%)
Similarity:	309/730 - (42%)	Gaps:	93/730 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIFVTL----AVGSLAIQGGVFKELTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFYGYACGNYA 70
            ::.|||    .|..||..|..::..|.|:......::.::.:.:.||.:|.||.||:.||||.:.
  Rat    69 VVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWI 133

  Fly    71 TINAATSQKDTNIRQLMFANYLRRVRQVLN---EPRISTDRPMEVRVKYFYESCLDTAALRTKQR 132
            ..|..   .|.:.|...|:|.....:.::.   |...::....|.:.:.:|.:|::...:...:.
  Rat   134 KANPV---PDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEKKAQVYYRACMNETRIEELRA 195

  Fly   133 SHLLSVLREFGGMPAVEGKSWDYVGFDAIEMMAQLLR----RYGKLTLLGVYVVPDHFNSQIKRL 193
            ..|:.::.:.||        |:..|..|.:.....|:    .|.......|||..|..||....:
  Rat   196 KPLMELIEKLGG--------WNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVI 252

  Fly   194 QLGQR----------LDLAESDEFASLWKKYALKMRLRNLL-GLSEELARKTAEEIIELELELSR 247
            |:.|.          |:..|:::..:.:..|  .::|..|| |..|:..|...::|::.|..|:.
  Rat   253 QVDQSGLGLPSRDYYLNKTENEKVLTGYLNY--MVQLGKLLGGGDEDSIRPQMQQILDFETALAN 315

  Fly   248 SAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLGSEYNLPVFESVP------SYLFQ 306
            ........||..|:.|....:.: ....|.:|...|:.:..   |.:.:.||.|      .||.|
  Rat   316 ITIPQEKRRDEELIYHKVTAAEL-QTLAPAINWLPFLNAIF---YPVEINESEPIVVYDKEYLRQ 376

  Fly   307 VKKILLSTPNHVVANYML-------SSLLTDFEITANEEQQKVI------CHERITELFPDVVDH 358
            |..::.||...::.|||:       ||.|......|:|:..:|:      |..|......|..::
  Rat   377 VSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENN 441

  Fly   359 M--------VYHSLEQQNPYIANEMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGMSF 415
            :        |..:..:.:..||:|   :.:|:|.:|.|.||:  ::|:::.||....||.:.: :
  Rat   442 LGFALGPMFVKATFAEDSKNIASE---IILEIKKAFEESLST--LKWMDEDTRRSAKEKADAI-Y 500

  Fly   416 EIAGGQAVNF-------EEQFGDLVVSSADYYGNIQRLLEVKARILRTDLLRESSSVYYYHGVTA 473
            .:.|  ..||       ::.|.|.......|:.|..|......|: ..|.||::.:...:   :.
  Rat   501 NMIG--YPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRV-TADQLRKAPNRDQW---SM 559

  Fly   474 TP-----IYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRG 533
            ||     .|....|.:|.|...:|..: :....|.||.:|.:|..:.||:.|.|||..|.||..|
  Rat   560 TPPMVNAYYSPTKNEIVFPAGILQAPF-YTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDG 623

  Fly   534 NLNDNWSTQTKVGFELVKNCLADQFSGMLYGNLRLRRLKSQAESIADNVGIRIAQSAYWKWLDQV 598
            ||...|...:...|:....|:..|::........:....:..|:||||.|::.|..||..|:.:.
  Rat   624 NLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKN 688

  Fly   599 EMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAMMINSPAFAEA 663
            ..|:.  ||.:..:..|||||..||..||...||.....:..:.|.|...||...:.||..|:|.
  Rat   689 GAEQI--LPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEH 751

  Fly   664 FQCSNSSKMNPPNKC 678
            |:|...|.|||.:||
  Rat   752 FRCPLGSPMNPRHKC 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	167/679 (25%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	168/679 (25%)
Ece1	XP_006239337.1	PepO	105..769	CDD:226118	172/694 (25%)
Ece1	XP_006239337.1	M13	118..767	CDD:189000	170/681 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920