DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl17 and ece2b

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_017206531.1	Gene:	ece2b / 793465	ZFINID:	ZDB-GENE-131120-140	Length:	794	Species:	Danio rerio

Alignment Length:	729	Identity:	174/729 - (23%)
Similarity:	300/729 - (41%)	Gaps:	129/729 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 IAKSAEMCSFMDTSVSPCDDFYGYACG-------------NYATINAATSQKDTNIRQLMFANYL 92
            :..::::...:|.|..||.|||.||||             .::|.|:...|....::.|
Zfish   101 VTVASKIVEALDRSADPCQDFYQYACGGWVRKNPLPDGRSRWSTFNSIWDQNQAVLKHL------ 159

  Fly    93 RRVRQVLNEPRISTDRPMEVRVKYFYESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVG 157
                  |.....::....|.:.:.:|.|||:...:.......|:.::.:.||....|  |||...
Zfish   160 ------LENGTFNSSSEAERKTQSYYLSCLNEQRIEELGAQPLMDLITKIGGWNITE--SWDKEN 216

  Fly   158 F-DAIEMMAQLLRRYGKLTLLGVYVVPDHFNSQIKRLQLGQR-LDLAESDEFASLWKKYALK--- 217
            | |.:::::...|.....| :.|.|.|.:.||.:  :|:.|. |.|...|.:.:...:..||
Zfish   217 FLDVLKIISGPYRAQPFFT-VSVSVDPKNSNSNV--IQVDQSGLFLPSRDYYLNKTNEKVLKAYL 278

  Fly   218 ---MRLRNLLGLSEELARKTAEEIIELELELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILN 279
               :.|..|||..:...|...::|::.|..|:.........||...:.|...:::: ....|.:.
Zfish   279 DYMVELGLLLGGDKNSTRGQMQQILDFETALANITVPQDERRDEEKIYHKITIADL-QVLAPAIE 342

  Fly   280 VTRFVTSWLGS-EYN--LPVFESVPSYLFQVKKILLSTPNHVVANYML--------SSLLTDFEI 333
            ...::.|.|.. |.|  .||......|:.||.:::..|.:.::.|||:        |||...||
Zfish   343 WLDYLNSVLSPLELNDTEPVVVYAKEYMQQVSELINKTDHSLLNNYMIWNLVQKGASSLDQRFE- 406

  Fly   334 TANEEQQKVI---------CHERITELFPDVVDHM--------VYHSLEQQ-------------- 367
               ..|.|::         |..|......:..|.:        |..:.::|
Zfish   407 ---NAQDKLLESLYGTKKSCTPRWQTCIGNTDDTLGFALGALFVKATFDKQSKEIDLNGGAFLPS 468

  Fly   368 -----NPYIANEMRSLWV-------ELKSSFREMLSSPDIEWLEKQTREELLEKLNGMSFEIAGG 420
                 |..:.|.|.|:..       |::::|:..|.  |::|:::|||:...:|.:.: :::.|
Zfish   469 CGRNVNSTVHNLMFSVITQAEGMINEIRTAFKGALD--DLKWMDEQTRQAAKDKADAI-YDMIG- 529

  Fly   421 QAVNFEEQFGDLVVSSAD--------------YYGNIQRLLEVKARILRTDLLRE--SSSVYYYH 469
                    |.|.::.|.:              ::.|:.......||:: .|.||:  :...:...
Zfish   530 --------FPDFILDSKELDDVYDGYEVTEDNFFQNMINFYNFSARVM-ADQLRKPPNRDQWSMT 585

  Fly   470 GVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRGN 534
            ..|....|....|.:|.|...:|..:...| :|.||.:|.:|..|.||:.|.|||..|.||..||
Zfish   586 PPTVNAYYMPTKNGIVFPAGILQAPFYAQD-HPKALNFGGIGVVMGHELTHAFDDQGREYDKDGN 649

  Fly   535 LNDNWSTQTKVGFELVKNCLADQFSGMLYGNLRLRRLKSQAESIADNVGIRIAQSAYWKWLDQVE 599
            |...|...:...|:....|:.||::........:...::..|:||||.|::.|..||..|:.  :
Zfish   650 LRSWWQNSSVEAFKNRTECMVDQYTQYTINGEHINGKQTLGENIADNGGLKAAYHAYRSWVQ--K 712

  Fly   600 MEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAMMINSPAFAEAF 664
            ..|.:.||.:..:.:||||:..||..||...||.....:..:.|.|.:.||...:.|||.|||.|
Zfish   713 NGEEKRLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPKYRVIGTLSNSPEFAEHF 777

  Fly   665 QCSNSSKMNPPNKC 678
            ||...|.||..::|
Zfish   778 QCPLGSSMNSGHRC 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	171/713 (24%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	171/713 (24%)
ece2b	XP_017206531.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020