DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl17 and MMEL1

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_258428.2	Gene:	MMEL1 / 79258	HGNCID:	14668	Length:	779	Species:	Homo sapiens

Alignment Length:	774	Identity:	178/774 - (22%)
Similarity:	323/774 - (41%)	Gaps:	126/774 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIFVTLAVGSLAIQGGVFKELTTPLGQQIMRIA------------------------KSAEMCSF 50
            |:.:.|...:|...|.::.:..   |:|:.|:|                        :.:|:|:.
Human    30 LLLLLLVTAALVALGVLYADRR---GKQLPRLASRLCFLQEERTFVKRKPRGIPEAQEVSEVCTT 91

  Fly    51 -------------MDTSVSPCDDFYGYACGNYATINAATSQKDTNIRQLMF---ANYLRRVRQVL 99
                         ||.:..||||||.:|||.:...:..   .:||.|..:|   .:.|..:.:.:
Human    92 PGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVI---PETNSRYSIFDVLRDELEVILKAV 153

  Fly   100 NEPRISTDRPMEVRVKYFYESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVGFD-AIEM 163
            .|...:.|||...:.:..|.||::.:.:..:....||.:|...||.|....:..:.||.: .:|.
Human   154 LENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVGGWPVAMDRWNETVGLEWELER 218

  Fly   164 MAQLLR-RYGKLTLLGVYVVPDHFNSQIKRLQLGQRLDLAESDEF------------ASLWKKYA 215
            ...|:. ::.:..|:.:::..|..||....:.:.|......|.|:            |.|....:
Human   219 QLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVS 283

  Fly   216 LKMRLRNLLGLSEE--LARKTAEEIIELELELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYG-PI 277
            :...||....|..:  |.::...:::|||.:|:::........|...:.|...|..:...:| ..
Human   284 VATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKG 348

  Fly   278 LNVTRFVTSWLGS------------EYNLPVFESVPSYLFQVKKILLSTPNHVVANYMLSSLLTD 330
            .|.|.|:.:.|.|            .|.:|       ||..::.|:.:.....:.||::..|:.|
Human   349 FNWTLFIQTVLSSVKIKLLPDEEVVVYGIP-------YLQNLENIIDTYSARTIQNYLVWRLVLD 406

  Fly   331 FEITANEEQQKVICHERITELFPDVVDHMVYHS-LEQQNPYIANEMRSLWV------ELKSSFRE 388
             .|.:..::.|.........||..:|:.:.:.. :...|..:.|.:.||:|      :.||..||
Human   407 -RIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRE 470

  Fly   389 MLSS---------PDIEWLEKQTREELLEKLNGMSFEIAGGQAV------NFEEQFGDLVVSSAD 438
            ::..         .::.|::::::::..||...:..:|.....:      ..:|::.:|..|...
Human   471 LIDKVRTVFVETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDL 535

  Fly   439 YYGNIQRLLEVKA-RILRTDLLRE--SSSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDI 500
            |:.|..:.|:|.| |.||.  |||  ..:::..........|....|.:|.|...:|..:...:
Human   536 YFENSLQNLKVGAQRSLRK--LREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKE- 597

  Fly   501 YPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQFSGMLYGN 565
            .|.||.:|.:|..:.||:.|||||..|.:|..||:.|.||..:...|.....|:..|     |||
Human   598 QPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQ-----YGN 657

  Fly   566 L--------RLRRLKSQAESIADNVGIRIAQSAYWKWLDQVEMEETESLPHMTQSPEQLFFLSAA 622
            .        .:....:..|:||||.|:|.|..||.||:  .|..:.:.||.:..:.|||||::.|
Human   658 YSWDLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWM--AEGGKDQQLPGLDLTHEQLFFINYA 720

  Fly   623 QFMCSDIYPERRANFVRNNFHPPYEARVFAMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681
            |..|....||.....::.:.|.|.:.||...:.|..|||:.|.|:..:.|:|..:|.::
Human   721 QVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	165/700 (24%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	165/687 (24%)
MMEL1	NP_258428.2	PepO	102..779	CDD:226118	168/697 (24%)
MMEL1	NP_258428.2	M13	111..777	CDD:189000	165/686 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920