DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl17 and ece1

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001071260.1	Gene:	ece1 / 777750	ZFINID:	ZDB-GENE-061110-100	Length:	752	Species:	Danio rerio

Alignment Length:	730	Identity:	172/730 - (23%)
Similarity:	312/730 - (42%)	Gaps:	78/730 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RLPASACLIFVTLAVGSLAIQGGVFKE------LTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDF 61
            :|....|.:.|.|.:..::: |..:||      |:.|.      ::.::.:...:|.||.||.||
Zfish    50 KLVVLVCALSVALFICIVSL-GLHYKESHPGLCLSEPC------VSVASAVLGSLDRSVDPCQDF 107

  Fly    62 YGYACGNYATINAATSQKDTNIRQLMFANY----LRRVRQVLNEPRISTDRPMEVRVKYFYESCL 122
            |.:|||.:...|.....|.   |...|:|.    :..::.:|....:.:....|.:.:::|::|:
Zfish   108 YNFACGGWMRKNPLPEGKS---RWGPFSNLWEHNMAVMKNLLENTSMKSLSRAEQKAQWYYQACM 169

  Fly   123 DTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVGFDAIEMMAQLLRRYGKLTLLGVYVVPDHFN 187
            :.:.:.......|..::.:.||. .::| .|:...|.  |::..:...:.......|:|..|..:
Zfish   170 NESKIEELGAKPLQDLINQTGGW-GLKG-PWEKDNFQ--EVLRIVSANFRTSPFFTVFVSTDSKS 230

  Fly   188 SQIKRLQLGQR----------LDLAESDEFASLWKKYALKMRLRNLLGLSEELARKTAEEIIELE 242
            |....:|:.|.          |:...::::.:.:..:.:::.:  |||.|::.::|..|||||.|
Zfish   231 SNSNIIQVDQSGLGLPSREYYLNKTANEKYLNAYLNFLVELGV--LLGGSQDTSQKMMEEIIEFE 293

  Fly   243 LELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTS-WLGSEYN--LPVFESVPSYL 304
            ..|:.........||...:.:......:: ...|.::...|::| :...|.|  .||......||
Zfish   294 TTLANITVPQVERRDEEKIYYKIQAKELA-TLAPAIDWMPFLSSVFAPVELNNSEPVVVYAKEYL 357

  Fly   305 FQVKKILLSTPNHVVANYMLSSLLTDFEITANEEQQ-------------KVICHERITELFPDVV 356
            .:|.:::.:|...|:.|||:..::.......:::.|             |..|..|......|..
Zfish   358 QKVSELISNTNKSVLNNYMIMKVVRKMVSILDQKFQDAEQRFLEVMYGTKKSCMPRWKLCVSDTD 422

  Fly   357 DHM--------VYHSLEQQNPYIANEMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGM 413
            ..:        |..:..:.:.....:|.|   |:|.:|.:.|.:  :.|::.:|::...||.:.:
Zfish   423 SALGFALGALFVKATFSEDSKAFVEDMVS---EIKWAFEDSLKT--VSWMDPETKKAAKEKADAI 482

  Fly   414 SFEIAG-----GQAVNFEEQFGDLVVSSADYYGNIQRLLEVKARILRTDLLRESSS--VYYYHGV 471
             :.:.|     ......::.|.|..|.|..|:.|:.......||: ..|.||::.:  .:.....
Zfish   483 -YNMVGYPKFIMNPKELDKVFNDFDVVSDLYFQNVMNYYNFSARV-TADQLRKAPNRDQWSMTPP 545

  Fly   472 TATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRGNLN 536
            |....|....|.:|||....|..: ::..:|.|:.:|.:|..|.||:.|.|||..|.||..|||.
Zfish   546 TVNAYYNPTKNEMVLPAGIFQAPF-YNHAWPKAMNFGGIGVVMGHELTHAFDDQGRKYDKDGNLA 609

  Fly   537 DNWSTQTKVGFELVKNCLADQFSGMLYGNLRLRRLKSQAESIADNVGIRIAQSAYWKWLDQVEME 601
            ..|...:...|:....|:.:|:|.....|..|....:..|:||||.|:..|..||..|:.  :..
Zfish   610 KWWQNSSVEAFQHQTQCMVEQYSNYSINNEPLNGKHTLGENIADNGGLNAAYKAYVNWIK--KNG 672

  Fly   602 ETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAMMINSPAFAEAFQC 666
            |..|||.:..:..||||:..||..||...||.....|..:.|.|...||...:.||..|:|.|.|
Zfish   673 EEASLPALGMNNHQLFFVGFAQVWCSVRTPESSHEGVITDPHSPSRFRVIGTISNSHEFSEHFGC 737

  Fly   667 SNSSKMNPPNKCLMY 681
            ...|.|||..||.::
Zfish   738 KADSPMNPKRKCELW 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	158/667 (24%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	159/667 (24%)
ece1	NP_001071260.1	PepO	94..752	CDD:226118	163/677 (24%)
ece1	NP_001071260.1	M13	101..750	CDD:189000	160/668 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020