Protein Alignment Nepl17 and mmel1

DIOPT Version :10

• Sequence 1: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: XP_017213856.1
• Gene: mmel1 / 560703
• ZFINID: ZDB-GENE-101112-2
• Length: 765
• Species: Danio rerio
• Alignment Length: 713
• Identity: 177/713 - (24%)
• Similarity: 312/713 - (43%)
• Gaps: 85/713 - (11%)

  Fly    31 TTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFYGYACGNYATINAATSQKDTNIRQLMFANYLRRV 95
            |||     ..:..:|.:...||.||.||.:||.||||.:...:..   .:|:....:| |.||..
Zfish    76 TTP-----QCVTAAARLLQNMDPSVDPCQNFYQYACGGWIERHVI---PETSSLHSVF-NILRDE 131

  Fly    96 RQV----LNEPRISTDRPMEVRVKYFYESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYV 156
            .::    :.|.....||....:.|..|.||::...:..:....||.::...|..| |..:.|:..
Zfish   132 LEIVLKGVLEMENKDDREAFKKAKTLYSSCMNEILIEQRDSQPLLRLIDSIGDWP-VASEVWNGT 195

  Fly   157 G---FDAIEMMAQLLRRYGKLTLLGVYVVPDHFNSQIKRLQLGQ-RLDLAESDEFAS-------- 209
            .   :...:.:|.|..||.|..:|.::|.||..:|....:.:.| .|.:...|.:.|
Zfish   196 SEQTWSLEDTLAVLNGRYNKKAVLEMFVWPDDRDSSRYIIHVDQPALGMPSRDYYLSDGNYKKVR 260

  Fly   210 -LWKKYALKM-RL----RNLLGLSEELARKTAEEIIELELELSRSAFDHRMNRDPRLMRHLTMLS 268
             .:.::.:.| |:    |||. ..||...:...:::|||.:::.:........|      :|:|.
Zfish   261 EAYLEFMVSMARIAREDRNLT-QDEERVLEDMSQVLELETDIANATSPAEERND------ITVLY 318

  Fly   269 N---MSDAYGPI----LNVTRFVTSWLGS-----EYNLPVFESVPSYLFQVKKILLSTPNHVVAN 321
            |   :.:|....    .|.||::...:.|     :.:.|:......||.::.::|....:..:.|
Zfish   319 NKMTLREAQQTFNLNGFNWTRYIQGIMSSVSISVQSDEPIVIYCSPYLEKLSEVLSKHSHRTLQN 383

  Fly   322 YMLSSLLTDFEITANEEQQKVICHER-------ITEL-FPDVVDHM------VYHSLEQQNPYIA 372
            |::..|:.|...:.:...:.|..|.|       :.|. :.|.|.::      ...:|..:..:..
Zfish   384 YLVWMLIMDRVSSMSRRFKDVRAHYRKALHGTTVEEARWRDCVRYVQGNMENAVGALYVRETFSG 448

  Fly   373 NEMR---SLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGMSFEIAGGQAV------NFEEQ 428
            |..|   .|..:::.::.|.|.  ::.|:::|::.:..||...:|.:|.....:      ..:::
Zfish   449 NSKRMVGELIKKIQEAYVETLE--ELSWMDEQSKVKAREKAMAISEQIGYPDHILEEENKKLDQE 511

  Fly   429 FGDLVVSSADYYGNIQRLLEVKARILRTDLLRE--SSSVYYYHGVTATPIYETETNLVVLPVSYM 491
            :..|..|..:|:.||...|...|: .....|||  ...::..........|....|.:|.|...:
Zfish   512 YAHLNFSEENYFENILENLAASAQ-KGHKKLREPVDPDMWIIGAAVVNAFYSHNRNQIVFPAGIL 575

  Fly   492 QHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRGNLNDNWSTQTKVGFELVKNCLAD 556
            |..: :.:....||.:|.:|..:.||:.|||||..|.:|..||:.:.||..:...||....|:.:
Zfish   576 QPPF-FSEKQLQALNFGGIGMVIGHEITHGFDDHGRNFDKDGNMYNWWSNYSAERFEDQSKCMVE 639

  Fly   557 Q---FSGMLYGNLRLRRLKSQAESIADNVGIRIAQSAYWKWLDQVEMEETESLPHMTQSPEQLFF 618
            |   ||..|.|...:..:.:..|:||||.|:|.|..||.||::: |.||.. ||.:..:.:||||
Zfish   640 QYGRFSWKLAGGQNVSGITTLGENIADNGGVRQAYKAYVKWVER-EGEEPR-LPGLDMNHKQLFF 702

  Fly   619 LSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681
            |:.||..|....||.....::.:.|.|.|.||...:.|..||:|||.|:..:.|||..||.::
Zfish   703 LNFAQVWCGACRPEYAIQTIKTDPHSPLEYRVLGSLQNFEAFSEAFHCARGAPMNPEEKCRVW 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	M13	55..678	CDD:341056	168/684 (25%)
mmel1	XP_017213856.1	M13	95..763	CDD:341056	169/685 (25%)