Protein Alignment Nepl17 and PHEX

DIOPT Version :10

• Sequence 1: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_000435.3
• Gene: PHEX / 5251
• HGNCID: 8918
• Length: 749
• Species: Homo sapiens
• Alignment Length: 750
• Identity: 187/750 - (24%)
• Similarity: 322/750 - (42%)
• Gaps: 115/750 - (15%)

  Fly     8 ACLIFV--TLAVGSLAIQGGVFKELTTPLGQQIMRIAKSAEMC-------------SFMDTSVSP 57
            |.::||  ||.:|::...          :.|.::.:....|.|             |.::.||.|
Human    22 ALVVFVGGTLVLGTILFL----------VSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDP 76

  Fly    58 CDDFYGYACGNYATINAATSQKDT-NIRQLMFANYLRRVRQVLNEPRISTDRPMEV--RVKYFYE 119
            ||:|:.:||..:.:.|.......: .:...:..|...:::::| |..||..|..|.  :.|..|.
Human    77 CDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELL-EKSISRRRDTEAIQKAKILYS 140

  Fly   120 SCLDTAALRTKQRSHLLSVLREFG-GMPAVEGK-----SWDYVGFDAIEMMAQLLRRYGKLTLLG 178
            ||::..|:.......||.:||... ..|.:|..     .|....|..::.:|....:|.....:.
Human   141 SCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIR 205

  Fly   179 VYVVPDHFNSQIKRLQLGQ-RLDLAESDEF------ASLWKK--YALKMRLRNLLGLSEELARKT 234
            :||.||...|....|:|.| .|.||..:::      |..::.  |...:....|||.:...|...
Human   206 LYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHD 270

  Fly   235 AEEIIELELELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLGSEYNLPVFES 299
            .:.::.||::::.....|. ||....|.:...:|.:|      ..:.:|  .|||  |...|.::
Human   271 MKSVLRLEIKIAEIMIPHE-NRTSEAMYNKMNISELS------AMIPQF--DWLG--YIKKVIDT 324

  Fly   300 ------------------VPSYLFQVKKILLSTPNHVVANYM--------LSSLLTDFEITANEE 338
                              ||.|...:.:||.|.....:|||:        :.:|...|:....|.
Human   325 RLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEF 389

  Fly   339 QQKVICHERITELFPDVVDHMVYHSLEQQNPYIANEM----------RSLWVEL----KSSFREM 389
            .:.:   :..|.|.|. .|..| :.:|...||:..:|          :.:..||    :.:|.:|
Human   390 SRVI---QGTTTLLPQ-WDKCV-NFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDM 449

  Fly   390 LSSPDIEWLEKQTREELLEKLNGMSFEIAGGQAV----NFEEQFGDLVVSSADYYGNIQRLLEVK 450
            |...: ||::..|:.:..||...:..::...:.:    :..|....:..|.|||:||:   |:.:
Human   450 LEKEN-EWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNV---LQTR 510

  Fly   451 ARILRTDL--LRES--SSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLG 511
            ..:.::|.  ||::  .:.::.:..|....|...||.:..|...:|..:.|...||.:|.||.:|
Human   511 KYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIG 575

  Fly   512 FTMAHEMAHGFDDLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQFSGMLY--GNLRLRRLKSQ 574
            ..:.||..||||:..|.||..|||:..|||:::..|:....|:.:|:|...:  ..|.::..::.
Human   576 VIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTL 640

  Fly   575 AESIADNVGIRIAQSAYWKWL-DQVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFV 638
            .|:||||.|:|.|..||.||: |:.:..|...||.:|.:..||||||.|...|:...||.....|
Human   641 GENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQV 705

  Fly   639 RNNFHPPYEARVFAMMINSPAFAEAFQCSNSSKMN 673
            :...|.|.:.||...:.|...|.:||.|..:|.||
Human   706 QIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMN 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	M13	55..678	CDD:341056	175/687 (25%)
PHEX	NP_000435.3	M13	74..740	CDD:341056	174/686 (25%)