DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nepl17 and MME

DIOPT Version :9

Sequence 1:NP_651641.1 Gene:Nepl17 / 43408 FlyBaseID:FBgn0039609 Length:681 Species:Drosophila melanogaster
Sequence 2:NP_000893.2 Gene:MME / 4311 HGNCID:7154 Length:750 Species:Homo sapiens


Alignment Length:760 Identity:188/760 - (24%)
Similarity:322/760 - (42%) Gaps:133/760 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LIFVTLAVGSLAI----QGGVFKELTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFYGYACGNYA 70
            |:...:||..:|:    ..|:.|....        |..:|.:...||.:..||.||:.||||.:.
Human    36 LLLTIIAVTMIALYATYDDGICKSSDC--------IKSAARLIQNMDATTEPCTDFFKYACGGWL 92

  Fly    71 TINAATSQKDTNIRQLMFANY--LRR-----VRQVLNEPRISTDRPMEVRVKYFYESCLDTAALR 128
            ..|..   .:|:.|   :.|:  ||.     ::.||.||: :.|.....:.|..|.||::.:|:.
Human    93 KRNVI---PETSSR---YGNFDILRDELEVVLKDVLQEPK-TEDIVAVQKAKALYRSCINESAID 150

  Fly   129 TKQRSHLLSVLREFGGMPAVEGKSWDY---VGFDAIEMMAQLLRRYGKLTLLGVYVVPDHFNSQI 190
            ::....||.:|.:..|.| |..::|:.   ..:.|.:.:|||..:|||..|:.::|..|..||..
Human   151 SRGGEPLLKLLPDIYGWP-VATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVN 214

  Fly   191 KRLQLGQ-RLDLAESD--EFASLWKK-----------YALKMRLRNLLGLSEELARKTAEEIIEL 241
            ..:.:.| ||.|...|  |...::|:           .|..:|....|.:.|........:::||
Human   215 HVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMEL 279

  Fly   242 ELELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLG------SEYNLPVFES- 299
            |.|::.:........||.|:.:...|:.:.:.:...:|...|  |||.      |..|:.:... 
Human   280 EKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPF--SWLNFTNEIMSTVNISITNEE 342

  Fly   300 -----VPSYLFQVKKILLSTPNHVVANYM--------LSSLLTDFEITANEEQQKVI-------- 343
                 .|.||.::|.||.......:.|.|        :|||...::.:.|..::.:.        
Human   343 DVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT 407

  Fly   344 ---CHERITELFPDVVDHMVYHSLEQQNPYIANEMRSLWVELKSSFREML--SSPDIEWLEKQTR 403
               |...:.....:.|..:...:.      .|.|.:.:..:|.:..||:.  :..|:.|::.:|:
Human   408 WRRCANYVNGNMENAVGRLYVEAA------FAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETK 466

  Fly   404 EELLEKLNGMSFEIAGGQAVNFEEQFG--DLVVSS---------------ADYYGN-IQRLLEVK 450
            :...||            |:..:|:.|  |.:||:               .:|:.| ||.|...:
Human   467 KRAEEK------------ALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQ 519

  Fly   451 ARILRTDLLRE--SSSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPA----ALKYGT 509
            ::.|:.  |||  ....:..........|.:..|.:|.|...:|..:     :.|    :|.||.
Human   520 SKQLKK--LREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPF-----FSAQQSNSLNYGG 577

  Fly   510 LGFTMAHEMAHGFDDLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQ---FSGMLYGNLRLRRL 571
            :|..:.||:.|||||..|.::..|:|.|.|:.|:...|:....|:..|   ||..|.|...|..:
Human   578 IGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGI 642

  Fly   572 KSQAESIADNVGIRIAQSAYWKWLDQVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRAN 636
            .:..|:||||.|:..|..||..::.  :..|.:.||.:..:.:|||||:.||..|....||...|
Human   643 NTLGENIADNGGLGQAYRAYQNYIK--KNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVN 705

  Fly   637 FVRNNFHPPYEARVFAMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681
            .::.:.|.|...|:...:.||..|:|||.|..:|.|||..||.::
Human   706 SIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nepl17NP_651641.1 PepO 49..672 CDD:226118 175/706 (25%)
M13 55..678 CDD:189000 176/706 (25%)
MMENP_000893.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Stop-transfer sequence. /evidence=ECO:0000255 16..23
M13 79..748 CDD:189000 177/705 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG3590
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D282463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11733
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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