Protein Alignment Nepl17 and MME

DIOPT Version :10

• Sequence 1: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Alignment Length: 760
• Identity: 188/760 - (24%)
• Similarity: 322/760 - (42%)
• Gaps: 133/760 - (17%)

  Fly    10 LIFVTLAVGSLAI----QGGVFKELTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFYGYACGNYA 70
            |:...:||..:|:    ..|:.|....        |..:|.:...||.:..||.||:.||||.:.
Human    36 LLLTIIAVTMIALYATYDDGICKSSDC--------IKSAARLIQNMDATTEPCTDFFKYACGGWL 92

  Fly    71 TINAATSQKDTNIRQLMFANY--LRR-----VRQVLNEPRISTDRPMEVRVKYFYESCLDTAALR 128
            ..|..   .:|:.|   :.|:  ||.     ::.||.||: :.|.....:.|..|.||::.:|:.
Human    93 KRNVI---PETSSR---YGNFDILRDELEVVLKDVLQEPK-TEDIVAVQKAKALYRSCINESAID 150

  Fly   129 TKQRSHLLSVLREFGGMPAVEGKSWDY---VGFDAIEMMAQLLRRYGKLTLLGVYVVPDHFNSQI 190
            ::....||.:|.:..|.| |..::|:.   ..:.|.:.:|||..:|||..|:.::|..|..||..
Human   151 SRGGEPLLKLLPDIYGWP-VATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVN 214

  Fly   191 KRLQLGQ-RLDLAESD--EFASLWKK-----------YALKMRLRNLLGLSEELARKTAEEIIEL 241
            ..:.:.| ||.|...|  |...::|:           .|..:|....|.:.|........:::||
Human   215 HVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMEL 279

  Fly   242 ELELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLG------SEYNLPVFES- 299
            |.|::.:........||.|:.:...|:.:.:.:...:|...|  |||.      |..|:.:...
Human   280 EKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPF--SWLNFTNEIMSTVNISITNEE 342

  Fly   300 -----VPSYLFQVKKILLSTPNHVVANYM--------LSSLLTDFEITANEEQQKVI-------- 343
                 .|.||.::|.||.......:.|.|        :|||...::.:.|..::.:.
Human   343 DVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT 407

  Fly   344 ---CHERITELFPDVVDHMVYHSLEQQNPYIANEMRSLWVELKSSFREML--SSPDIEWLEKQTR 403
               |...:.....:.|..:...:.      .|.|.:.:..:|.:..||:.  :..|:.|::.:|:
Human   408 WRRCANYVNGNMENAVGRLYVEAA------FAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETK 466

  Fly   404 EELLEKLNGMSFEIAGGQAVNFEEQFG--DLVVSS---------------ADYYGN-IQRLLEVK 450
            :...||            |:..:|:.|  |.:||:               .:|:.| ||.|...:
Human   467 KRAEEK------------ALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQ 519

  Fly   451 ARILRTDLLRE--SSSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPA----ALKYGT 509
            ::.|:.  |||  ....:..........|.:..|.:|.|...:|..:     :.|    :|.||.
Human   520 SKQLKK--LREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPF-----FSAQQSNSLNYGG 577

  Fly   510 LGFTMAHEMAHGFDDLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQ---FSGMLYGNLRLRRL 571
            :|..:.||:.|||||..|.::..|:|.|.|:.|:...|:....|:..|   ||..|.|...|..:
Human   578 IGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGI 642

  Fly   572 KSQAESIADNVGIRIAQSAYWKWLDQVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRAN 636
            .:..|:||||.|:..|..||..::.  :..|.:.||.:..:.:|||||:.||..|....||...|
Human   643 NTLGENIADNGGLGQAYRAYQNYIK--KNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVN 705

  Fly   637 FVRNNFHPPYEARVFAMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681
            .::.:.|.|...|:...:.||..|:|||.|..:|.|||..||.::
Human   706 SIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	M13	55..678	CDD:341056	176/706 (25%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	177/705 (25%)