DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl17 and Ece2

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_006248635.1	Gene:	Ece2 / 408243	RGDID:	1303039	Length:	912	Species:	Rattus norvegicus

Alignment Length:	725	Identity:	180/725 - (24%)
Similarity:	314/725 - (43%)	Gaps:	68/725 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MERLPASACLIFVTLAVGSLA---IQGGVFKELTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFY 62
            :|.:.|...|:...|.:|.|.   :|.......:|.:.:..:|:|  .::...:|..||||.|||
  Rat   206 LELVLAGLILVLAALLLGCLVALWVQYHRDPVHSTCITEACIRVA--GKILESLDRGVSPCQDFY 268

  Fly    63 GYACGNYATINAATSQKDT-NIRQLMFANYLRRVRQVLNEPRISTDRPMEVRVKYFYESCLDTAA 126
            .::||.:...|...|.:.. |....::......::.:|.....::....|.:.:.||.|||....
  Rat   269 QFSCGGWIRRNPLPSGRSRWNTFNSLWDQNQAILKHLLENSTFNSSSEAERKTRSFYLSCLHLER 333

  Fly   127 LRTKQRSHLLSVLREFGGMPAVEGKSWDYVGFDAIEMMAQLLRRYGKLTLLGVYVVPDHFNSQIK 191
            :.......|..::.:.||. .:.| .||...|  :|::..:...|.......|||..|..:|...
  Rat   334 IEKLGAKPLQDLIDKIGGW-NITG-PWDEDNF--MEVLKAVAGTYRAAPFFTVYVGADSKSSNSN 394

  Fly   192 RLQLGQR----------LDLAESDEFASLWKKYALKMRLRNLLGLSEELARKTAEEIIELELELS 246
            .:|:.|.          |:...:::..:.:..|.:::.:  |||......|...::::|||::|:
  Rat   395 IIQVDQSGLFLPSRDYYLNRTANEKVLAAYLDYMVELGM--LLGGQPTSTRAQMQQVLELEIQLA 457

  Fly   247 RSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLGSEYNL----PVFESVPSYLFQV 307
            .........||...:.|...:|.: ....|.::...|: |:|.|...|    ||......||.||
  Rat   458 TITVPQDQRRDEEKIYHKMSISEL-QTLAPSMDWLEFL-SFLLSPLELGDSEPVVVYGTEYLQQV 520

  Fly   308 KKILLSTPNHVVANYML--------SSLLTDFEITANEEQQKVI------CHERITELFPDVVDH 358
            .:::..|...::.||::        |||...|| ||.|:..:.:      |..|......:..|.
  Rat   521 SELINRTEPSILNNYLIWNLVQKTTSSLDQRFE-TAQEKLLETLYGTKKSCTPRWQTCISNTDDA 584

  Fly   359 M--------VYHSLEQQNPYIANEMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGMSF 415
            :        |..:.::|:..||..|.|   |::::|.|.|.  ::.|::::||....||.:.: :
  Rat   585 LGFALGSLFVKATFDRQSKEIAEGMIS---EIRAAFEETLE--NLVWMDEKTRLAAKEKADAI-Y 643

  Fly   416 EIAGG-----QAVNFEEQFGDLVVSSADYYGNIQRLLEVKARILRTDLLRE--SSSVYYYHGVTA 473
            ::.|.     :....::.:....||...::.|:..|....|::: .|.||:  |...:.....|.
  Rat   644 DMIGFPDFILEPRELDDVYDGYEVSEDSFFQNMLNLYNFSAKVM-ADQLRKPPSRDQWSMTPQTV 707

  Fly   474 TPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRGNLNDN 538
            ...|....|.:|.|...:|..: :...:|.||.:|.:|..|.||:.|.|||..|.||..|||...
  Rat   708 NAYYLPTKNEIVFPAGILQAPF-YAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDQEGNLRPW 771

  Fly   539 WSTQTKVGFELVKNCLADQFSGMLYGNLRLRRLKSQAESIADNVGIRIAQSAYWKWLDQVEMEET 603
            |..::...|:....|:.:|::.......||..|::..|:||||.|::.|.:||..||.  :..|.
  Rat   772 WQNESLTAFQNHTACMEEQYNQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLR--KHGEE 834

  Fly   604 ESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAMMINSPAFAEAFQCSN 668
            :.||.:..:..||||:..||..||...||.....:..:.|.|...||...:.||..|...|.|..
  Rat   835 QPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPV 899

  Fly   669 SSKMNPPNKC 678
            .|.|||...|
  Rat   900 GSPMNPGQLC 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	166/666 (25%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	168/666 (25%)
Ece2	XP_006248635.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	250..903	CDD:226118	167/673 (25%)
		M13	261..910	CDD:189000	169/668 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920