DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl17 and Nep2

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	787	Identity:	181/787 - (22%)
Similarity:	318/787 - (40%)	Gaps:	148/787 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPASACLIFVTLAVG------------------SLAIQGGVFKELTTPLGQQIM-RIAKSAEMC- 48
            |..|..::||.||.|                  :.|:.|........|.|.... :...|.::|
  Fly    21 LLVSLGIMFVVLATGFGLWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTASKGKSGDSGDVCL 85

  Fly    49 ------------SFMDTSVSPCDDFYGYACGNYATINAATSQKDTNIRQLMFANYLRRVRQVLNE 101
                        ..|...|.|||:||.:|||.|.   ...:..|..:....|:....::::.|.:
  Fly    86 TQECIHTASTVLRKMKPEVEPCDNFYEFACGTYL---EEENIPDDKVSISTFSVISDKLQEQLKD 147

  Fly   102 PRISTDRPMEVRVKYF------YESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVGFDA 160
             .|:.:|| |...|:|      |::|::...:.|.....:..|....||.|.::|.||:   .|.
  Fly   148 -IITAERP-ETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWN---ADD 207

  Fly   161 IEMMAQLLRRYGKLTLLGVYVVP-----DHFNSQIKRLQLGQRLDLAESDEF---------ASLW 211
            .....:.::::........|::.     |..||..:.:.|.|. .||.|.|:         .:.:
  Fly   208 SWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQS-SLALSREYLVKGFNETLVTAY 271

  Fly   212 KKYALKMRLRNLLGLSEELARKTAEEIIELELELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGP 276
            .||.:.:.:  |.|.:.:||:......:|.|:.|:..::.:...|:...:.:|...:.:..|| |
  Fly   272 YKYMVDIAV--LFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAY-P 333

  Fly   277 ILNVTRFVTSWLGSEYNLPVFE----SVPSYLFQVKKILLSTPNHVVANYM--------LSSLLT 329
            .:....::.:.|....|:...|    ||||:...:.|:|..||..|:||||        :..|..
  Fly   334 YVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSE 398

  Fly   330 DFE---------ITANEEQQ--------------KVICHERITELFPDVVDHMVYHSLEQQNPYI 371
            :|.         ::..:||:              ..:|.:....|...|....|.....:.:...
  Fly   399 EFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKAN 463

  Fly   372 ANEMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGMSFEIAGGQAV------------- 423
            |.||.:   |:::.|.::|.  ::.|::.:|::|...||:.|:..|.....:
  Fly   464 ALEMVN---EIRNVFNDILD--EVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKL 523

  Fly   424 -----NFEEQFGDLVVSSADYYGNIQRLLEVKARILRTDLLRESSSVYYYHGVTATPIYETETNL 483
                 .:.|.|..:.:...||..|..||     .:.:||.:|.:      ........|.:..|.
  Fly   524 DIDPDKYFESFLGMNIFGTDYSFNKLRL-----PVNKTDWVRHA------RPAIVNAFYSSLENS 577

  Fly   484 VVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRGNLNDNWSTQTKVGFE 548
            :..|...:|..: ::...|..:.:|.:|:.:.||:.|||||..|.:|.:|||.|.|...|:..:.
  Fly   578 IQFPAGILQGHF-FNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYL 641

  Fly   549 LVKNCLADQFSGMLYGN-------LRLRRLKSQAESIADNVGIRIAQSAYWKWLDQVEMEETESL 606
            ....|:.:|     |||       |.|..:.:|.|:||||.|::.:..||.:|.::...|  ..|
  Fly   642 AKAKCIIEQ-----YGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPE--AKL 699

  Fly   607 PHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAMMINSPAFAEAFQCSNSSK 671
            |.:..:|||:|:::|.|..|:....|.....:....|.|.|.||...:.|...||:.|.|...|.
  Fly   700 PGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSP 764

  Fly   672 MNPPNKC 678
            |||..||
  Fly   765 MNPVQKC 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	163/702 (23%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	165/702 (24%)
Nep2	NP_001246914.1	M13	104..772	CDD:189000	167/704 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920