Protein Alignment Nepl17 and KEL

DIOPT Version :10

• Sequence 1: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Alignment Length: 693
• Identity: 158/693 - (22%)
• Similarity: 287/693 - (41%)
• Gaps: 117/693 - (16%)

  Fly    52 DTSVSPCDDFYGYACGNYATINAATSQKDTNIRQLMFANYLRRVRQVLN--EPRISTDRPMEVRV 114
            :|||:||.||:.:|||.....|.:..:..|..:     |.|||:.:|.|  .|....::..:
Human   106 NTSVAPCTDFFSFACGRAKETNNSFQELATKNK-----NRLRRILEVQNSWHPGSGEEKAFQ--- 162

  Fly   115 KYFYESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVGFDAIEMMAQLLRRYGKLTLLGV 179
              ||.||:||.|:.......|..|:.|.||. .:.|| |..:.|:  ..:..|:.:||.......
Human   163 --FYNSCMDTLAIEAAGTGPLRQVIEELGGW-RISGK-WTSLNFN--RTLRLLMSQYGHFPFFRA 221

  Fly   180 YVVPDHFNSQIKRLQLGQ---RLDLAESDE---FASLWKKYALKM-RLRNLLGLSEELARKTAEE 237
            |:.|...:.....:|:.|   .:.|.:..|   :|.::::|...: :|..|||...    ...:|
Human   222 YLGPHPASPHTPVIQIDQPEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDP----SKVQE 282

  Fly   238 IIELELELSRSAFD-----HRMNRDPRLMRHLTM--LSNMSDA--YGPILNVTRFVTSWLGSEYN 293
            ...|.:.::...|.     .:.....:|.:.:|:  |..|:.|  :...|..| |....|....:
Human   283 HSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQAT-FTPMSLSPSQS 346

  Fly   294 LPVFESVPSYLFQ----VKKILLSTPNHVVANYMLSSLLT-------DFEITANEEQQKVICHER 347
            |.|.:  ..||..    |:::||...:.:.::.:|..::|       .|:....:..||:   ..
Human   347 LVVHD--VEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKL---RE 406

  Fly   348 ITELFPDVVDHMVYHSLEQQNPYIANEMRSLWV-------------ELKSSFREMLSS--PDIEW 397
            :||..|..........:|:...:....:.:|:|             :|.::.|:.|.:  .::.|
Human   407 LTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPW 471

  Fly   398 LEKQTREELLEKLNGMSFEIAGGQ-AVNFE---EQFGDLVVSSADYYGNIQRLLEVKARILRTDL 458
            :.::|:....:|:..:..|:...: |:..|   :::.|:.:.|:.....:..:..::|||:::.|
Human   472 MNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFL 536

  Fly   459 LRESSSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFD 523
            .......:..........|....::||.|...:|..:.... ||.|:.:|..|..||||:.|.|.
Human   537 QPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPG-YPRAVNFGAAGSIMAHELLHIFY 600

  Fly   524 DLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQFSGMLYGNLRLRR------LKSQA------- 575
            .|                      .|...|||.....:...:|.|:|      |.|:.
Human   601 QL----------------------LLPGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLT 643

  Fly   576 --ESIADNVGIRIAQSAYWKWLDQVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFV 638
              |:.||..|:.||..||.|.|.:...|..  ||.:..||:|:||.|.||.||....|:.
Human   644 FLENAADVGGLAIALQAYSKRLLRHHGETV--LPSLDLSPQQIFFRSYAQVMCRKPSPQD----- 701

  Fly   639 RNNFHPPYEARVFAMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681
            .::.|.|...||...:.::||||..|:|:..:.:||.::|.::
Human   702 SHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	M13	55..678	CDD:341056	155/685 (23%)
KEL	XP_005250050.1	M13	109..742	CDD:341056	155/686 (23%)