DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl17 and Nepl8

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_609795.2	Gene:	Nepl8 / 34983	FlyBaseID:	FBgn0032585	Length:	619	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	156/738 - (21%)
Similarity:	274/738 - (37%)	Gaps:	193/738 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CLIFVTLAVGSLAIQGGVFKELTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFYGYACGNYATIN 73
            ||:.|.|...|          ..|.|...|:         |.:|...:||:::|.:|||.|...:
  Fly     5 CLLLVPLVAAS----------SNTRLLNGIL---------SHVDKEANPCENYYNHACGQYNMRH 50

  Fly    74 AATSQKDT--NIRQLMFANYLRRVRQVLNEPRISTDRP------MEVRVKYFYESCLDTAALRTK 130
            .    .||  :|.|::.....:.:.::::|..:|:..|      ::.:|..:|.||.. |.....
  Fly    51 I----DDTFFDIIQMLDHQVNQNLVKLMDELEMSSQLPDFNVSSVDGKVLRYYLSCRG-APRNMD 110

  Fly   131 QRSHLLSVLREFGGMP----AVEGKSWDYVGFDAIEMMAQLLRRYGKLT--LLGVYVVPDHFNSQ 189
            ..|..|.|:....|:.    ..:|.||....|..::.:|. |.||| ||  ...:.||.:..|:.
  Fly   111 SLSQYLKVISPGEGLTWPQFIPDGSSWPQENFKWLKALAH-LHRYG-LTNVFFNLEVVSNPRNAS 173

  Fly   190 IKRLQL-----GQRLDLAES-DEFASLWKKYALKMRLRNLLGLSEELARKTAEEIIELELELSRS 248
            ...::|     |:...|..| .|..|:  .|.:|:....::    .||||.  ..:||.|:...:
  Fly   174 EYMVELNTPTFGEESQLPNSFIEILSV--LYIIKVPSSEII----TLARKM--RTLELLLKTMIN 230

  Fly   249 AFDHRMNRDPRLMRHLTMLS-NMSDAYGPILNVTRFVTSWLGSEY--NLPVFESVPSYLFQVKKI 310
            ..|...|      |::::.. .|...:    |..||....:||..  .|.|......|...:|::
  Fly   231 PIDTLNN------RYISIRDFQMETGH----NWQRFFEILIGSSAAPELQVLVRNFRYFTALKEL 285

  Fly   311 LLSTPNHVVANYMLSSLLTDFEITANEE----QQKVICHERITELFPDVVDHMVY-HSLEQQNPY 370
            :......:||:|    ::|.|.|...:|    ::...|..::.... ::..:|:| ....:.:.:
  Fly   286 MDKQDARLVASY----IMTRFAIFLLDETMGGRESTECVSQVRRNM-NLAANMLYKERFFEDSTF 345

  Fly   371 IAN--EMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGMSFEIAGGQAVNFE------- 426
            .||  |::.::.:|:..|...:....:|....|           |.|.:...:|:...
  Fly   346 SANILEIKDIFEKLRHQFLLQVDQNHLELTALQ-----------MKFFVRKAEAIEINVVNLPKT 399

  Fly   427 --------EQFGDL--VVSSADYYGNIQRLLEVKARILRTDLLRESS-------SVYYYHGVTA- 473
                    :.:.||  .....||:....::|:.:.:    .:|.:||       ::..|....|
  Fly   400 DDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRTQ----KMLAQSSKGHSEEQNILTYRSQAAP 460

  Fly   474 ----TPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRGN 534
                .|.::.|:                :|::    ||..:|:.|||.:...|........|.||
  Fly   461 LPPPQPFFQLES----------------EDVF----KYSLMGYIMAHHLISAFATEGITIGSDGN 505

  Fly   535 LNDNWSTQTKVGFELVKNCLADQFSGMLYGNLRLRRLKSQAESIADNVGIRIAQSAYWKWLDQVE 599
            .....|.:    ||...:||:             |..::..||:.|..|:.:|...|.|......
  Fly   506 DQSFRSHR----FEEAVSCLS-------------RNSENIDESMGDIAGLELAYFTYAKMAKNRN 553

  Fly   600 MEETESLPHMTQSPEQLFFLSAAQFMC--SDIYPERRANFVR-----NNFHPPYEARVFAMMINS 657
            ..:...||     |||:|||:..||.|  ||:..:.:.:.||     ..|.|
  Fly   554 RLDFTHLP-----PEQIFFLNVGQFFCGNSDMLVQYKEDQVRLQRAIEGFEP------------- 600

  Fly   658 PAFAEAFQCSNSSKMNPP--NKC 678
              |.:||.|..    |.|  .||
  Fly   601 --FDKAFGCYR----NKPKHEKC 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	144/688 (21%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	144/690 (21%)
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	146/692 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840