DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl17 and Nepl7

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	727	Identity:	156/727 - (21%)
Similarity:	281/727 - (38%)	Gaps:	193/727 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 MCSFMDTSVSPCDDFYGYACG-------------NYATINAATSQKDTNIRQLMFANYLRR-VRQ 97
            :.|.|:.::.||::||.::||             |.:.:||...:.|..|:     .:|:. .::
  Fly    44 LLSTMNRTIDPCENFYEFSCGGWKKADLVPEQARNTSFLNAIQHKIDEQIQ-----GFLQNATKR 103

  Fly    98 VLNEPRISTDRPMEVRVKYFYESCLDTAAL--------------RTKQRSHLLSVLREFGGMPAV 148
            .|.:..::.....|::.|.||.||::..|.              |.|:|:...
  Fly   104 ELEDLGVNGTTSAEIKAKQFYASCVEMKANLSLGYQYFMEHDGDRLKERNATY------------ 156

  Fly   149 EGKSWDYVGFDAIEMMAQLLRRYGKLTLLGVYVVPDHFNSQIKRLQLGQRLDLAESDEFASLWKK 213
               .|.|:.|         :.:|....||.:.|   |:::..::..:
  Fly   157 ---DWMYINF---------MSKYDIYPLLALKV---HYSTSSRKFDI------------------ 188

  Fly   214 YALKMRLRNLLGLSEE-LARKTAEEIIELELELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPI 277
             .|.:..:.|.|.||| |...|.|..::...|..:. |....|...:..|:|..|:...:....:
  Fly   189 -LLTLPSKVLAGFSEEQLKNMTREFGLDSSAEKVKQ-FVENFNNLTQFERNLVSLAKSRNETEQL 251

  Fly   278 -------------LNVTRFV-TSWLGS-EYNLPV---FESVPSYLFQVKKILLSTPNHVVANYML 324
                         ||.|||. .::.|| |.:.||   .:::...:|.:::..|.|    :..|:.
  Fly   252 NFKEFLVKHKHDRLNWTRFFELAFNGSQESHWPVLNQLDNINDLVFFLEQTNLET----LKGYIK 312

  Fly   325 SSLLTDF---------------EITANEEQQ-----------KVICHERITELFPDVVDHMVYHS 363
            ...|..|               |..:..|..           ||...||..::.
  Fly   313 MRELVKFYGLWKTQTKTGGVQSECRSLSETYFNYALLPWFIGKVFDKERRADIL----------- 366

  Fly   364 LEQQNPYIANEMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGMSFEIAGGQAVNFEEQ 428
                         |:..::|.:|.::|...  .||::.||.:...||  .|.:|..|...:.:.:
  Fly   367 -------------SVAKDIKDTFYDLLDHH--TWLDEDTRSQAKTKL--ASMDILVGYTDDLQHR 414

  Fly   429 ------FGDLVVSSADYYGNIQRLLEVKARI-LRT------DLLRESSSVYYYHGVTATPIYETE 480
                  :.|:.: :.:::.|:..|...:||| ||:      .||..:.:|..|        |...
  Fly   415 EVIDGVYSDINM-TGNWFENLCILEGSRARIRLRSVDKALIPLLMPTRTVNAY--------YADF 470

  Fly   481 TNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRGNLNDNWSTQTKV 545
            .||..:.:...|..:...| :|..|||..:|..:.||||||||.....|:..|...:.||:.:..
  Fly   471 LNLAFITIGMAQWPFYHID-FPDVLKYAGVGNIIGHEMAHGFDSYCYQYNYDGKKTNWWSSASLR 534

  Fly   546 GFELVKNCLADQFSGMLYGNLRLRRLKSQAESIADNVGIRIAQSAYWK------WLDQVEMEETE 604
            .|:....||..|::..:...::.....:..::||||||.|:|..|:.:      ||:       :
  Fly   535 NFKERYRCLESQYNKFILMGVQTNGSLTSGDNIADNVGTRMAYYAFKRKTGDKAWLE-------K 592

  Fly   605 SLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAMMINSPAFAEAFQCSNS 669
            .|..:..:.:||||:..||..|:......:...::.:.|...|.||...:.|.|.|:|||.|...
  Fly   593 PLRGVNFNNKQLFFVKFAQTWCNGKDNGDKLRRLKTDVHAYDEFRVQGTLSNMPEFSEAFNCKLG 657

  Fly   670 SKMNPPNKCLMY 681
            ::|||..||:::
  Fly   658 TEMNPLKKCVVW 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	151/714 (21%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	152/714 (21%)
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	156/725 (22%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	152/714 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469678
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850