DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl17 and Nepl6

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	752	Identity:	178/752 - (23%)
Similarity:	294/752 - (39%)	Gaps:	179/752 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ACLIFVTLAVGSLAIQGGVFKELTTPLGQQIMRIAKSAEM---CSFMDTSVSPCDDFYGYACGNY 69
            |||..|.:.              ..|..|.:.....|..|   .|::....|.|..::.||||.|
  Fly     5 ACLFIVPIC--------------AAPTTQNVEADPNSRLMNNILSYVAEDSSACGTYFQYACGKY 55

  Fly    70 AT----------INAATSQKDTNIRQLMFANYLRRVRQVLNEPRISTDRPMEVRVKYFYESCLDT 124
            |.          |.....:.:.|:.|||...:.|......||..:      |.:|.:||.:|.:
  Fly    56 AVRHRDDPFTEIIQMLDHKVNGNLVQLMHELHQRSQSPGFNESSV------EAKVLHFYRTCRE- 113

  Fly   125 AALRTKQRSHLLSVL--------REFGGMPAVEGKSWDYVGFDAIEMMAQLLRRYG-KLTLLGVY 180
            |...|::..|.|.:.        .:|  ||  .|:.|....|..::.:..|. ||| ...|:.|.
  Fly   114 APPSTRKMEHYLRLAPPGQALTWPQF--MP--RGEPWPKAQFKWMKSLGHLY-RYGFTNVLVNVL 173

  Fly   181 VVPDHFNSQIKRLQLGQRLDLAESDEFASLWKKYALKMRLRNLLGLSEELARKTAEEIIELE--- 242
            |:....||  .|.:|...:...|.|              .::|.|....||   ..:||.:.
  Fly   174 VLRSSENS--NRFRLDISMPSLEGD--------------AQHLGGFLSTLA---TLQIIGVPTKS 219

  Fly   243 -LELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVT--SWLGSEYNLPVFESV---- 300
             |.|.|     ::.|....:|.||.:.:..::....|....:.|  :|.|...:: |..||
  Fly   220 ILPLVR-----KIRRLESAIRVLTEVDDDDESETWTLRQWEYKTGYAWQGFVESI-VGHSVSHHY 278

  Fly   301 ------PSYLFQVKKILLSTPNHVVANYMLSS----LLTDFEITANEEQQKVICHERITEL--FP 353
                  ..|...:|:::.||...|||||:::.    |:.|| |.:||.   :.|   :|::  ..
  Fly   279 VMQAQNAKYFTGLKRLMDSTDAEVVANYIMTRFVLYLIDDF-IDSNEH---IDC---VTDMRRNM 336

  Fly   354 DVVDHMVYH-------SLEQQNPYIANEMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLN 411
            ::..:::|.       :|:|    ...|:..::.:|:..|...::         :.|..|..:.|
  Fly   337 NLASNLLYKERFLDPATLQQ----YTQEVTKVFEQLRRQFLLQIN---------ENRLGLTSEQN 388

  Fly   412 GMSFEIAGGQAVNF-------------EEQFGDLV--VSSADYYGNIQRLLEVKAR--ILRTDLL 459
            .|....|....:|.             ...:.|||  :...||......|||.:.|  :|:.:..
  Fly   389 SMVATKAQHVVLNIGNLPRGRDHRSFVSRHYEDLVFPLPDFDYAREHLNLLEFRTRKQVLQLNQS 453

  Fly   460 RESSSVYYY-----HGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMA 519
            ..:...::|     ..:::.|.|....|::|:|...:|..:...|.:. ..||..|||.:|||:.
  Fly   454 APTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHD-IFKYSLLGFVLAHELM 517

  Fly   520 HGFDDLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQFSG---MLYGNLRLRRLKSQ--AESIA 579
            |..|.:...||..||:::                :..|.|.   .:.|...|.|..:|  .|.||
  Fly   518 HSVDTVGLYYDRYGNIHE----------------IGPQISSSPRFVAGLQCLNRNSTQYLDERIA 566

  Fly   580 DNVGIRIAQSAYWKWLDQVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHP 644
            |..|:.:|.|.|::...|:.:.:..::|     |:|:|||:.|||.|.|..|   .|||.   |.
  Fly   567 DIAGLDLAYSTYFQNSSQMSLTDFTTIP-----PQQIFFLNLAQFFCGDGDP---INFVG---HD 620

  Fly   645 PYEARVFAMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681
            ..|.|:..|:.....|.|||.|  .:|.|.|.||.::
  Fly   621 NDETRLQQMLNGFAPFHEAFGC--PAKSNQPEKCQLW 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	165/697 (24%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	167/697 (24%)
Nepl6	NP_609023.3	M13	42..653	CDD:189000	168/697 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469650
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840