DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl17 and Nepl5

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster

Alignment Length:	768	Identity:	182/768 - (23%)
Similarity:	311/768 - (40%)	Gaps:	171/768 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MERLPASACLIFVTLAVGSLAIQGGVFKELTTPL------GQQIMRIAKSAEMCSFMDTSVSPCD 59
            |.:|...|.|||      |||.:       |||.      ..|.::...:.::.|:|||...||:
  Fly     1 MLKLSLVAWLIF------SLAWR-------TTPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCE 52

  Fly    60 DFYGYACGNYATINAATSQKDTNIR-------------QLMFANYL--------RRVRQVL---N 100
            :||.|||||:    ....|:..::|             |::..:.|        |::..:|   |
  Fly    53 NFYQYACGNW----QIQQQEQHSLRDRDWTRDRQRYQGQMLPTDTLGLIDHSVNRKLELLLRRRN 113

  Fly   101 EPRISTDRPMEVRVKYFYESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVG-------F 158
            |....:|..:..:::.:|.||........|:...||         |......|..||       |
  Fly   114 ESSFESDSSILEQMRLYYRSCKRLKPYNLKKYLQLL---------PPSNSTQWPSVGRGWRPERF 169

  Fly   159 DAIEMMAQLLRRYGKLTLLGVYVVPDHFNSQIKRLQLGQRLDLAESDEFASLWKKYALK------ 217
            |.|..:       |:|.|.|:       |..:.|.::..|.|  :|..::....|.:.:
  Fly   170 DWITTL-------GRLRLHGL-------NGVLLREEVLPRWD--DSRNYSIYVNKPSRQETQPMG 218

  Fly   218 ----MRLRNLLGLSEELARKTAEEIIELELELSRSAFDHRM-----NRDPRLMRHLTMLSNMSDA 273
                :.|...:|.::..|...|.::.:.|.:|      ||:     :..||.|: |..|    |:
  Fly   219 EGAMIELLLDIGQTKRTANALARQVDDFERKL------HRLQELEDDEGPREMQ-LGYL----DS 272

  Fly   274 YGPILNVTRFVTS-WLGSEYNLP---VFESVPSYLFQVKKILLSTPNHVVANYMLSSLLTDFEIT 334
            |.|.|....|:.. .:.||.:|.   :.|::| ||..:..::.|.....|.:|::...|...:..
  Fly   273 YLPQLRWLSFMRQVRIDSELDLRSTLIIENIP-YLRALSDLMESESPDTVCSYIMLKWLAFLKQQ 336

  Fly   335 ANEEQQKVICHERITELFPDVVDHMVYHSLEQQNPYIANEMRSLWVELKSSFREMLS------SP 393
            ...:..:..|...:....|.....:|  ..:..:|...:.:.||:..||..|.::|:      ||
  Fly   337 GPADISRGECVAALRRAMPLASSWLV--GQQFSDPESESYVSSLFQRLKVRFGQILAENRMRLSP 399

  Fly   394 DIEWLEKQTREELLEKLNGMSFEIAGGQAVNFE--EQFGDLV-VSSADYYGNIQRLLEVKARI-L 454
            .:..:       |.:||..:..::...|....|  ||:...: :|...:|||  :|:.::.|: .
  Fly   400 PLVHI-------LQQKLRAVRLQMGFFQTEEIEDVEQYHVRIDLSGHSFYGN--QLVLLRQRVEA 455

  Fly   455 RTDLL---------RESSSVYY----YHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAALK 506
            ..|||         ...|::.|    :....::|:|....|||::|...:| ..:|.....|..:
  Fly   456 NHDLLYINVTNFANSTGSNLSYLSESWEASNSSPLYVRPRNLVLVPHGLLQ-LPIWHRNISALQQ 519

  Fly   507 YGTLGFTMAHEMAHGFDDLNRLYDSRGNL-----NDNWSTQTKVGFELVKNCLADQFSGMLYGNL 566
            :..:||.:|||:|||||.|...||:.||:     ....|.|.:.|.:    ||..|   |..|:
  Fly   520 HAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQ----CLQQQ---MATGS- 576

  Fly   567 RLRRLKSQAESIADNVGIRIAQSAYWKWLDQVEMEETESLPHMTQSPEQLFFLSAAQFMCSD--- 628
                 |...|.:||.|.:|:|...::...|:.|..: ..||..:|  .||||::.|||.|..
  Fly   577 -----KWIDEKLADFVALRLAYETFFGVRDKREPRD-PLLPQFSQ--RQLFFITFAQFFCGRTPV 633

  Fly   629 IYPERRANFVRNNFHPPYEARVFAMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681
            :.|  |:....:..|...|.||...:.|...|:..|.|...:||....:|.::
  Fly   634 LSP--RSQSEAHLKHAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	166/703 (24%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	164/703 (23%)
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	169/712 (24%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	164/704 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469648
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850