DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl17 and Nep6

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	734	Identity:	188/734 - (25%)
Similarity:	303/734 - (41%)	Gaps:	177/734 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LTTPLGQQIMRIAKSAEMC-----SFMDTSVSPCDDFYGYACGNYATINAATSQK---DTNIRQL 86
            |...||..::::| :|:.|     :..|..|.||::|:.|||||:   .:.|||:   ..::|..
  Fly    11 LVVILGVMLLKLA-AAQDCQQQLDNDTDAEVKPCENFHQYACGNW---YSNTSQRILGAHDMRSK 71

  Fly    87 MFANYLRRVRQVLNEPRISTDRPMEVRVKYFYES---CLDTAALRTKQRSHLLS----------V 138
            ..||...::.:.|.|.. |||.        |..:   ...||.|.|..|..|||          :
  Fly    72 WVANLKLQLIRYLEESS-STDS--------FSANTSVTTSTAQLGTLYRCCLLSGQSIRTYTDAL 127

  Fly   139 LREFGGMPAV---EGKSWDYVGFDAIEMMAQLLRRYGKLTLLGVYVVPDHFNSQIKRL--QLGQR 198
            .|.....|.:   .|.|:|:|..:|      .||.||...|..: :|.|::.|..:|:  .|..:
  Fly   128 SRSGANFPLLANHTGGSFDWVLANA------ALRTYGAQGLWRL-LVKDNWQSADQRIFYMLPPK 185

  Fly   199 LDLA----ESDEFASLWKKYALKMRLRNLLGLSEELARKTAEEIIELELELSR----SAFDHRMN 255
            .||.    |.:||  |:::| ||:.|.. |||....|...||:::..|..|.:    .|....:.
  Fly   186 FDLLGRDDELNEF--LYQRY-LKILLLE-LGLRVRRAALLAEKLVAFEKSLQKLLPNDAEQTLVL 246

  Fly   256 RDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWL-GSEYNLPVFESVP--SYLFQVKKIL---LST 314
            |.|:.::.|       ::..|.|.:.|:..:.| |.:::......|.  .||..::::|   .|.
  Fly   247 RKPQSLKDL-------ESQLPRLELKRYFETILEGIDWDSKTLLLVADLDYLQGLQRLLAEHTSD 304

  Fly   315 PNHVVANYMLSSLLTDFEITANEE----QQKVICHERITELFPDVVDHM------------VYHS 363
            | .|::.::|..|...||:..:::    .|:..|.|::.:|.|..:..:            ||.:
  Fly   305 P-MVLSTWLLLQLPAYFELRLHDDDKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDT 368

  Fly   364 LEQQNPYIANEMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGMSF-------EIAGGQ 421
            ..||       :..|:.:||..|..:|:..::...:..||....:||..|..       .|.||.
  Fly   369 AIQQ-------IAVLFRDLKQQFELVLNETEVFNEDLVTRNLARDKLRAMRLLTPRLQDPINGGP 426

  Fly   422 AVNFEEQFGDLVVSSADYYGNIQRLLEVKARILRTDLLRESSSVYYYHGVTATPI---------- 476
            ..   .|.|          ||..      |.:|:..|   |.:...|..|...|:
  Fly   427 GT---PQLG----------GNCD------ANLLQLSL---SQAKLEYRQVFGEPVTSVPADPLSV 469

  Fly   477 ---YETETNLVVLPVSYM-----QHRYLWDDIYPAALKYGTLGFTMAHEMAHGF--DDLNRLYDS 531
               |..:.|.:.||:..|     |.:...:....|.|..| ||:.:||||.|.|  |.||  ||:
  Fly   470 NAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAG-LGYILAHEMVHAFDLDGLN--YDA 531

  Fly   532 RGNL-NDNWSTQTKVGFELVKNCLADQFSGMLYGNLRLRRLKSQAESIADNVGIRIAQSAYWKWL 595
            .|.| |..||.:..:.|.|...|    :.|:.|.|..|    :..|:|||..|:|:|...|
  Fly   532 TGQLANGQWSARAIIRFGLRAGC----YLGVRYSNATL----TVNENIADTEGLRLALDTY---- 584

  Fly   596 DQVEMEETESLPHMTQSPE-QLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAMMINSPA 659
                       .|.:.:.. :.||::.||..|..:     |:....:.|..:..||..::.|.|.
  Fly   585 -----------RHRSGATNLRTFFVAFAQNWCGTV-----ASTSGLSQHAGHAERVNNVVGNMPE 633

  Fly   660 FAEAFQCSNSSKMNPPNKC 678
            |.:.|:|..:|:|||.|||
  Fly   634 FGDTFECKATSQMNPVNKC 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	176/702 (25%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	179/702 (25%)
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	182/709 (26%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	181/704 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469656
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850