Protein Alignment Nepl17 and Phex

DIOPT Version :10

• Sequence 1: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_037136.2
• Gene: Phex / 25512
• RGDID: 3323
• Length: 749
• Species: Rattus norvegicus
• Alignment Length: 742
• Identity: 187/742 - (25%)
• Similarity: 316/742 - (42%)
• Gaps: 97/742 - (13%)

  Fly     6 ASACLIFVTLAVGSLAIQGGVFKELTTPLGQQIMRIAKSAEMC-------------SFMDTSVSP 57
            |.|..|..||.:|:|...          :.|.::......|.|             |.::.||.|
  Rat    22 ALALFITGTLVLGTLLFL----------VSQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVDP 76

  Fly    58 CDDFYGYACGNYATINAATSQKDT-NIRQLMFANYLRRVRQVLNEPRISTDRPMEV--RVKYFYE 119
            |::|:.:||..:.:.|.......: .:...:..|...:::.:| |..:|..|..|.  :.|..|.
  Rat    77 CENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKALL-EKSVSRRRDTEAVQKAKILYS 140

  Fly   120 SCLDTAALRTKQRSHLLSVLREFG-GMPAVEGK-----SWDYVGFDAIEMMAQLLRRYGKLTLLG 178
            ||::..|:.......||.:||... ..|.:|..     .|....|..::.:|....:|.....:.
  Rat   141 SCMNEKAIEKADAKPLLHILRHSPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIR 205

  Fly   179 VYVVPDHFNSQIKRLQLGQ-RLDLAESDEF------ASLWKK--YALKMRLRNLLGLSEELARKT 234
            :||.||...|....|:|.| .|.||..::|      |..::.  |...:....|||.:...|...
  Rat   206 LYVSPDDKASNEHILKLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLLGANSSRAEHD 270

  Fly   235 AEEIIELELELSRSAFDHRMNRDPRLMRHLTMLSNMS------DAYGPILNV--TRFVTSW--LG 289
            .:.::.||::::.....|. ||....|.:...:|.:|      |..|.|..|  ||.....  :|
  Rat   271 MKSVLRLEIKIAEIMIPHE-NRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIG 334

  Fly   290 SEYNLPVFESVPSYLFQVKKILLSTPNHVVANYM--------LSSLLTDFEITANEEQQKVICHE 346
            ...|:.|  .||.|...:.:||.:.....:|||:        :.:|...|:....|..:.:   :
  Rat   335 PSENVVV--RVPQYFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVI---Q 394

  Fly   347 RITELFPDVVDHMVYHSLEQQNPYIANEM----------RSLWVEL----KSSFREMLSSPDIEW 397
            ..|.|.|. .|..| :.:|...||:..:|          :.:..||    :.:|.:||...: ||
  Rat   395 GTTTLLPQ-WDKCV-NFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKEN-EW 456

  Fly   398 LEKQTREELLEKLNGMSFEIAGGQAV----NFEEQFGDLVVSSADYYGNIQRLLEVKARILRTDL 458
            ::..|:.:..||...:..::...:.:    ...|....:..|.:||:||:   |:.:..:.::|.
  Rat   457 MDAGTKRKAQEKARAVLAKVGYPEFIMNDTYVNEDLKAIKFSESDYFGNV---LQTRKYLAQSDF 518

  Fly   459 --LRES--SSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMA 519
              ||::  .:.::.:..|....|...||.:..|...:|..:.|...||.:|.||.:|..:.||..
  Rat   519 FWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFT 583

  Fly   520 HGFDDLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQFSGMLY--GNLRLRRLKSQAESIADNV 582
            ||||:..|.||..|||:..||..::..|:....|:.:|:|...:  ..|.::..::..|:||||.
  Rat   584 HGFDNNGRKYDKNGNLDPWWSVDSEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNG 648

  Fly   583 GIRIAQSAYWKWL-DQVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPY 646
            |:|.|..||.||: |:.:..|...||.:|.:..||||||.|...|:...||.....|:...|.|.
  Rat   649 GLREAFRAYRKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPP 713

  Fly   647 EARVFAMMINSPAFAEAFQCSNSSKMN 673
            :.||...:.|...|.:||.|..:|.||
  Rat   714 QFRVNGAISNFEEFQKAFNCPANSTMN 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	M13	55..678	CDD:341056	175/680 (26%)
Phex	NP_037136.2	M13	74..740	CDD:341056	173/678 (26%)