Protein Alignment Nepl17 and ECE1

DIOPT Version :10

• Sequence 1: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Alignment Length: 732
• Identity: 185/732 - (25%)
• Similarity: 310/732 - (42%)
• Gaps: 98/732 - (13%)

  Fly    10 LIFVTLAVGSLAIQG--GVFKELTTP---LGQQIMRIAKSAEMCSFMDTSVSPCDDFYGYACGNY 69
            ::.|.||.|.:|...  |:..:..:|   |.:..:.:..|  :.|.||.:|.||.||:.||||.:
Human    79 VLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSS--ILSSMDPTVDPCHDFFSYACGGW 141

  Fly    70 ATINAATSQKDTNIRQLMFANYLRR----VRQVLNEPRISTDRPMEVRVKYFYESCLDTAALRTK 130
            ...|..   .|.:.|...|:|....    ::.:|.....|... .|.:.:.:|.:|::...:...
Human   142 IKANPV---PDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSE-AERKAQVYYRACMNETRIEEL 202

  Fly   131 QRSHLLSVLREFGGMPAVEGKSWDYVGFDAIEMMAQLLR----RYGKLTLLGVYVVPDHFNSQIK 191
            :...|:.::...||        |:..|..|.:.....|:    .|.......|||..|..||...
Human   203 RAKPLMELIERLGG--------WNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSN 259

  Fly   192 RLQLGQR----------LDLAESDEFASLWKKYALKMRLRNLL-GLSEELARKTAEEIIELELEL 245
            .:|:.|.          |:..|:::..:.:..|  .::|..|| |..||..|...::|::.|..|
Human   260 VIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNY--MVQLGKLLGGGDEEAIRPQMQQILDFETAL 322

  Fly   246 SRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLGSEYNLPVFESVP------SYL 304
            :.........||..|:.|....:.: ....|.:|...|:.:..   |.:.:.||.|      .||
Human   323 ANITIPQEKRRDEELIYHKVTAAEL-QTLAPAINWLPFLNTIF---YPVEINESEPIVVYDKEYL 383

  Fly   305 FQVKKILLSTPNHVVANYML-------SSLLTDFEITANEEQQKVI------CHERITELFPDVV 356
            .|:..::.:|...::.|||:       ||.|......|:|:..:|:      |..|......|..
Human   384 EQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTE 448

  Fly   357 DHM--------VYHSLEQQNPYIANEMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGM 413
            :::        |..:..:.:..||.|   :.:|:|.:|.|.||:  ::|::::||:...||.:.:
Human   449 NNLGFALGPMFVKATFAEDSKSIATE---IILEIKKAFEESLST--LKWMDEETRKSAKEKADAI 508

  Fly   414 SFEIAGGQAVNF-------EEQFGDLVVSSADYYGNIQRLLEVKARILRTDLLRESSSVYYYHGV 471
             :.:.|  ..||       ::.|.|.......|:.|..|......|: ..|.||::.:...:
Human   509 -YNMIG--YPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRV-TADQLRKAPNRDQW--- 566

  Fly   472 TATP-----IYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLYDS 531
            :.||     .|....|.:|.|...:|..: :....|.||.:|.:|..:.||:.|.|||..|.||.
Human   567 SMTPPMVNAYYSPTKNEIVFPAGILQAPF-YTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDK 630

  Fly   532 RGNLNDNWSTQTKVGFELVKNCLADQFSGMLYGNLRLRRLKSQAESIADNVGIRIAQSAYWKWLD 596
            .|||...|...:...|:....|:.:|:|........:....:..|:||||.|::.|..||..|:.
Human   631 DGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVK 695

  Fly   597 QVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAMMINSPAFA 661
            :...|  .|||.:..:..|||||..||..||...||.....:..:.|.|...||...:.||..|:
Human   696 KNGAE--HSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFS 758

  Fly   662 EAFQCSNSSKMNPPNKC 678
            |.|:|...|.||||:||
Human   759 EHFRCPPGSPMNPPHKC 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	M13	55..678	CDD:341056	171/680 (25%)
ECE1	XP_011539174.1	M13	127..776	CDD:341056	173/682 (25%)