DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl17 and nep-20

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001317749.1	Gene:	nep-20 / 188176	WormBaseID:	WBGene00020293	Length:	834	Species:	Caenorhabditis elegans

Alignment Length:	710	Identity:	152/710 - (21%)
Similarity:	272/710 - (38%)	Gaps:	165/710 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 IAKSAEMCSFMDTSVSPCDDFYGYACGNYATINAATSQKDTNIRQLMFANYLRRVRQVLNEPRIS 105
            |..:.|:.::.|||||.|.:||...||.|....|....:|...::::    .|.||:.|.....|
Worm   221 ITLAFELSAYQDTSVSKCHNFYKATCGKYKHHQALDKHRDAKKKEVV----KRIVREFLRRNESS 281

  Fly   106 TDRPMEVRVKYFYESCLDTAALRTKQRSHLLSVLRE---FGGMPAVEGKSWDYVGFDAIEMMAQL 167
            .....|..::..:..|     .:..|....|.:.::   .|..|.:: ..|..|.|:..:.:..|
Worm   282 ITSKFEPAIRLMFGKC-----NKFSQNKTYLDIFKDIEKIGPWPVLK-SDWVDVMFNLNDYLLSL 340

  Fly   168 LR----RYGKLTL------LGVY--VVPDH--FNSQIKRLQL------GQRLDLAESDEFASLWK 212
            :.    .:|...|      .|.:  :.|..  ..:|::::.|      |.:.|..:..::...:.
Worm   341 VELGFTDFGLFKLEFRQLAFGQFPVIAPSEQKQGNQLEKIILEILEANGVQADRQKLSKYLREYS 405

  Fly   213 KYALKMRLRNLLGLSEELARKTAEEIIELELELSRSAFDHR---MNRDPRLMRHL---TMLSNMS 271
            ::..::|..:|.|.|.:..|..|.     .|.::.||...:   |:....|:|.:   .:::|.|
Worm   406 EFKSQLRHMSLEGTSVKYIRYNAS-----TLSVNISALVQKMAPMSTSSGLVRRIQSGILITNSS 465

  Fly   272 DAYGPILNVTRFVTSWLGSEYNLPVFESVPSYLFQVKKILLSTPNHVVANYMLSSLL--TDFEIT 334
            ..:|..|:.                             |:..|....:|||::...:  ..|::|
Worm   466 SFFGKNLDA-----------------------------IIQQTHKRTLANYLIFHFIDAVTFDLT 501

  Fly   335 ANEEQQKVICHERITELFP---------DVVDHMVYHSLEQQNPYIANEMRSLWVELKSSFREML 390
            :..:..:    ..:.:|.|         |.||.      |.|...:  ||..   :||....||:
Worm   502 SGAKHSE----HTLIDLLPRGSLQVLSQDFVDE------EDQGVMV--EMAK---DLKKHVVEMI 551

  Fly   391 ---SSPDIEWL--EKQTREELLEKLNGM------SFEIAGGQAVNFEEQFGDLVVSSADYYGNIQ 444
               ||.|...|  |::.|.:|:.|:..:      ..||..   .|||:       .:..|..::.
Worm   552 SEGSSLDKGHLVFEEKERRKLIRKVQDILVVTKYPLEILN---QNFEK-------LNLTYSDSLH 606

  Fly   445 RLLEVKARILRTDLLRESSSVYYYHGVTATPI---------YETETNLVVLPVSYMQHRYLWDDI 500
            :::: |.|..|::.|.|      |.|....|.         ||..||.:::....:...| :|..
Worm   607 KIIQ-KLRRFRSEQLIE------YLGGDLDPTDKGMWGSAHYEQATNDLIIIAPIIDGPY-FDTS 663

  Fly   501 YPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRGNLNDNW-STQTKVGFELVKNCLADQFSGMLYG 564
            ||..:....:||.::.|:....|.:....|.:|: .:|| .:::...|:....|...:.:|..:.
Worm   664 YPNYVNIFFMGFIISRELGRSLDSVRIRKDEKGH-TENWLKSESLKRFDNNVKCWRKKITGTRFL 727

  Fly   565 NLRLRRLKSQAESIADNVGIRIAQSAYWKWLDQVE---MEETESLPHMTQSPEQLFFLSAAQFMC 626
            |          |.:||:||...:..|..||..::.   :|:......||.  ||:||...|.:.|
Worm   728 N----------EMLADHVGHEASFMALKKWEKEMNGTIVEKIRGYESMTM--EQIFFHLQALYFC 780

  Fly   627 SDIYP-----ERRANFVRNNFHPPYEARVFAMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681
            ..  |     |..|...|.:    |..||.....|.|.||:||.||::..||...||..:
Worm   781 RP--PGGSTGELTAKDARQH----YSTRVNEAFKNMPQFAKAFGCSSNQNMNSKTKCTFF 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	146/691 (21%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	145/691 (21%)
nep-20	NP_001317749.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920