Protein Alignment Nepl17 and nep-2

DIOPT Version :10

• Sequence 1: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_494343.2
• Gene: nep-2 / 188090
• WormBaseID: WBGene00020230
• Length: 736
• Species: Caenorhabditis elegans
• Alignment Length: 738
• Identity: 201/738 - (27%)
• Similarity: 319/738 - (43%)
• Gaps: 157/738 - (21%)

  Fly    41 IAKSAEMCSFMDTSVSPCDDFYGYACGNY-----ATINAATSQKDTNIRQ-LMFANYLRRVRQVL 99
            |..::.:.|.|::||.||||||.:|||.:     ...:|.:.....|:.| |.||     ::::|
 Worm    59 IKTASVILSSMNSSVDPCDDFYEFACGQWIKGHPIPDDAPSVSNFENLGQDLEFA-----LKELL 118

  Fly   100 NEPRISTDRPMEV------RVKYFYESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVGF 158
            :|    .|.|.:.      :.||||..||:.:.:....|:....|::.|||        |..:|.
 Worm   119 DE----NDEPYDYETSAVGKAKYFYNLCLNESEILDNWRTTFDEVVKSFGG--------WPSLGH 171

  Fly   159 D-----AIEMM-AQLLRRYGKLTLLGVYVVPDHFNSQIKRLQLGQ-RLDL--------AESDEFA 208
            .     :|||: |.::.::...:|....|.||..|||...|.:.| :|:|        ||::|
 Worm   172 QMKPDASIEMLYADMVAKFKADSLFKATVQPDDKNSQRHVLLIDQPQLNLFARDFYVAAENEE-- 234

  Fly   209 SLWKKYALKMRLRN-LLGLSEELARKT--AEEIIELELELSR--SAFDHR-----------MNRD 257
                :.|....:|: |:.|..:..|.|  |:|||:.|..|:.  .|.:||           :...
 Worm   235 ----RMAYLQLIRDVLILLDADRTRATLDAKEIIDFETALANITMADEHRHDIAELYTKITLGEM 295

  Fly   258 PRLMRHLT-------MLSNMSDAYGPILNV---TRFVTSWLGSEYNLPVFESVPSYLFQVKKILL 312
            .|.:.|..       |..::.:..|..:..   |..|.  .|.|:...:...:|.|
 Worm   296 RRSLPHFNWPLFFNRMFKDLHEKNGKRITFDDNTEVVV--YGYEFLRRLDVLIPQY--------- 349

  Fly   313 STPNHVVANY---------MLSSLLTDFEITANE--------EQQKVI---CHERITELFPDVVD 357
              .|.::.||         ||..|...|.:|..:        ..|||.   |..||..|.| :..
 Worm   350 --DNRLIVNYLEWCWFFKTMLRDLPDPFALTIFKFYKTLNIMNVQKVRWHGCVTRINSLMP-MAT 411

  Fly   358 HMVY------HSLEQQNPYIANEMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGMSFE 416
            ..:|      |..:||    ..||.||.:|   ||.::|.|.|  ||.|:|::...:|:|.|..:
 Worm   412 SAIYVKNHFDHEAKQQ----VEEMISLIME---SFVDLLLSED--WLTKETKQTAKQKVNEMKRK 467

  Fly   417 IA------GGQAVN-----FEEQFGDLVVSSADYYGNIQRLLEVKARILRTDLL-RESSSVYYYH 469
            |.      ...|||     |:...|....:...:|...||  :|..||  |:.: ||.   :...
 Worm   468 IGYPDYLNDPAAVNNEYKTFKVYPGHYYQTKFSFYEQYQR--DVLERI--TEAVDRER---WVAG 525

  Fly   470 GVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRGN 534
            .......|...||.::.|...:|..:...| :|:::.:|.:|..:.||:.|||||..||||:.||
 Worm   526 AALVNAFYSPNTNEIIFPAGILQPVFYSKD-FPSSMNFGGIGVVIGHEITHGFDDRGRLYDNLGN 589

  Fly   535 LNDNWSTQTKVGFELVKNCLADQFSGMLYG--NLRLRRLKSQAESIADNVGIRIAQSAYWKWLDQ 597
            :...|...|...||....|:..|:|..:..  |:::....::.|:||||.|::.|..||.|:
 Worm   590 IRQWWDNATISKFEHKAQCIEKQYSSYVLDQINMQINGKSTKGENIADNGGLKQAYRAYKKY--- 651

  Fly   598 VEMEETES----LPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAMMINSP 658
               |:..|    ||.:..:.:|||||:.||..|..:..:.....:|.:.|.|...||...:.||.
 Worm   652 ---EKRHSRPPRLPGVNLTHDQLFFLNYAQIWCGTMNDKEAIRKLRTSEHSPGPIRVKGPLSNSY 713

  Fly   659 AFAEAFQCSNSSKMNPPNKCLMY 681
            .||:|:.|...|:|||..||.::
 Worm   714 DFAKAYNCEPGSQMNPREKCRVW 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	M13	55..678	CDD:341056	195/719 (27%)
nep-2	NP_494343.2	M13	73..734	CDD:341056	196/720 (27%)