Protein Alignment Nepl17 and nep-18

DIOPT Version :10

• Sequence 1: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_494297.1
• Gene: nep-18 / 186911
• WormBaseID: WBGene00019343
• Length: 701
• Species: Caenorhabditis elegans
• Alignment Length: 715
• Identity: 177/715 - (24%)
• Similarity: 290/715 - (40%)
• Gaps: 136/715 - (19%)

  Fly    49 SFMDTSVSPCDDFYGYACGNYATINAATSQKDTNIRQLMFANYLRRVRQVLNEPRISTDRPMEVR 113
            ::.:.||.||:||:.:.||.|    :.....|.:...:.:...|.:|..:..:......:|.| :
 Worm    41 NYQNASVDPCEDFFEHTCGRY----SEHVMDDNSWGYVQYKQLLYQVFAIARKTNKFNSKPNE-Q 100

  Fly   114 VKYFYESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVGFDAIEMMAQLL----RRYGKL 174
            ::.|.:||||...:.......|.:.:.|.||.|.:: .:|:...||..:|:|:.|    .|.|.|
 Worm   101 LRIFTKSCLDRKEMDEDTFQDLRNDIEERGGFPMID-PNWNEEKFDLSDMLAKYLSINRNRMGFL 164

  Fly   175 TLLGVYVVPDHFNSQIKRLQLGQRLDLAESDEFASLWK------KYALKMRLRNLL-----GLSE 228
            ::.....:..  |..:.||.      ::....:...|.      |.::...||.||     .|:|
 Worm   165 SVEPYAAIEG--NKSVNRLY------VSPGPHWVYNWAMGISIYKDSVAFMLRRLLKLENRELNE 221

  Fly   229 ELARKTAEEIIELELELSRSAFDHRM----NRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLG 289
            .:..|...|:::||...|..| |:|.    |.:....|:||.|..|......|..:.........
 Worm   222 TIYDKEFAELVQLEANFSTLA-DYRNLALDNDNMSKSRNLTDLVKMIPEIDWIKILKALARHGTS 285

  Fly   290 SEYNLPVFESVP-----SYLF----QVKKILLSTPNHVVANYMLSSLLTDFEI------------ 333
            .|....:.|.|.     .|.|    ::.:|...||...:|||::...|.|..:
 Worm   286 EEDEEKLLERVTVHGAGEYFFGENRELARIATETPKSALANYLVVRQLIDVALYFYDKDQPRQNK 350

  Fly   334 TANEEQQKVICHERITELFPDVVDHMVYHSLEQQNPYIANE---------MRSLWVELKSSFREM 389
            ..|...|:..|..::...||          :...|.:|.:.         :..::|::|:.:.::
 Worm   351 FYNHVDQQSFCATQVASFFP----------MPSMNVFIESSQFKIENLKVIEEMFVKIKAEYEQI 405

  Fly   390 LSSPDIEWLEKQTREELLEKLNGMSFEIAGGQAVNFEEQFGDLVVSSADYYGNIQRLLE---VKA 451
            .:  :.|:||.:.||.|:.|||.:            :.:||      .|.|...:.|||   ...
 Worm   406 FT--ENEYLELEIREFLIRKLNAI------------DGKFG------LDQYTEGKPLLEKMYETL 450

  Fly   452 RILRTD--------LLRESSSVYYYHGVTATPI-------------YETETNLVVLPVSYMQHRY 495
            ..|.||        :.|..|.....|.|..||:             |:...|...:.:.|:  .|
 Worm   451 NFLDTDSPWQVYMKMWRHWSEQLVEHIVHDTPLDPVNLKMFGTHAAYQPYPNHFYINLPYL--TY 513

  Fly   496 LWDDI-YPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRGNLNDNWSTQT---KVGFELVKNCLAD 556
            .|.|. :||...||.||:.:.||:.|.||..:|..|..|.....|.|:|   ...:||.:.||.|
 Worm   514 PWMDADFPANTNYGYLGYVIGHEIGHAFDHFHRKLDESGRQQQYWFTETNSSNTEYELREKCLRD 578

  Fly   557 QFSGMLYG----NLRLRRLKSQAESIADNVGIRIAQSAYWKWLDQVEMEETESLPHMTQSPEQLF 617
            |:|.  |.    :..:.....:.|...|::|||.|    ::..::|:.|:...||.:..|.||||
 Worm   579 QYSA--YKEPGYDFFMNGTHCRYEIAGDHMGIRTA----FRVFEKVKKEDRFRLPGLEMSEEQLF 637

  Fly   618 FLSAAQFMCSDIY-PERRANFVRNNFHPPYEARVFAMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681
            |.:.|...| |:| |.:....:....||....||..::.|.|.|||||.|..:|.|||..||.:|
 Worm   638 FYNYAFRQC-DVYNPNKLPRNMLARQHPTNRYRVNGVIQNIPEFAEAFNCPKNSPMNPEMKCKLY 701

  Fly   682  681
             Worm   702  701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	M13	55..678	CDD:341056	173/704 (25%)
nep-18	NP_494297.1	M13	47..699	CDD:341056	174/705 (25%)