DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl17 and Phex

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_035207.1	Gene:	Phex / 18675	MGIID:	107489	Length:	749	Species:	Mus musculus

Alignment Length:	742	Identity:	187/742 - (25%)
Similarity:	317/742 - (42%)	Gaps:	97/742 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ASACLIFVTLAVGSLAIQGGVFKELTTPLGQQIMRIAKSAEMC-------------SFMDTSVSP 57
            |.|..|..||.:|:|...          :.|.::......|.|             |.::.||.|
Mouse    22 ALALFIGGTLVLGTLLFL----------VSQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVDP 76

  Fly    58 CDDFYGYACGNYATINAATSQKDT-NIRQLMFANYLRRVRQVLNEPRISTDRPMEV--RVKYFYE 119
            |::|:.:||..:.:.|.......: .:...:..|...:::.:| |..:|..|..|.  :.|..|.
Mouse    77 CENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKALL-EKSVSRRRDTEAVQKAKILYS 140

  Fly   120 SCLDTAALRTKQRSHLLSVLREFG-GMPAVEGK-----SWDYVGFDAIEMMAQLLRRYGKLTLLG 178
            ||::..|:.......||.:||... ..|.:|..     .|....|..::.:|....:|.....:.
Mouse   141 SCMNEKAIEKADAKPLLHILRHSPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIR 205

  Fly   179 VYVVPDHFNSQIKRLQLGQ-RLDLAESDEF------ASLWKK--YALKMRLRNLLGLSEELARKT 234
            :||.||...|....|:|.| .|.||..::|      |..::.  |...:....|||.:...|...
Mouse   206 LYVSPDDKASNEHILKLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLLGANSSRAEHD 270

  Fly   235 AEEIIELELELSRSAFDHRMNRDPRLMRHLTMLSNMS------DAYGPILNV--TRFVTSW--LG 289
            .:.::.||::::.....|. ||....|.:...:|.:|      |..|.|..|  ||.....  :|
Mouse   271 MKSVLRLEIKIAEIMIPHE-NRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIG 334

  Fly   290 SEYNLPVFESVPSYLFQVKKILLSTPNHVVANYM--------LSSLLTDFEITANEEQQKVICHE 346
            ...|:.|  .||.|...:.:||.:.....:|||:        :.:|...|:....|..:.:   :
Mouse   335 PSENVVV--RVPQYFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVI---Q 394

  Fly   347 RITELFPDVVDHMVYHSLEQQNPYIANEM----------RSLWVEL----KSSFREMLSSPDIEW 397
            ..|.|.|. .|..| :.:|...||:..:|          :.:..||    :.:|.:||...: ||
Mouse   395 GTTTLLPQ-WDKCV-NFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKEN-EW 456

  Fly   398 LEKQTREELLEKLNGMSFEIAGGQAV----NFEEQFGDLVVSSADYYGNIQRLLEVKARILRTDL 458
            ::..|:.:..||...:..::...:.:    ...|....:..|.:||:||:   |:.:..:.::|.
Mouse   457 MDAGTKRKAQEKARAVLAKVGYPEFIMNDTYVNEDLKAIKFSESDYFGNV---LQTRKYLAQSDF 518

  Fly   459 --LRES--SSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMA 519
              ||::  .:.::.:..|....|...||.:..|...:|..:.|...||.:|.||.:|..:.||..
Mouse   519 FWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFT 583

  Fly   520 HGFDDLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQFSGMLY--GNLRLRRLKSQAESIADNV 582
            ||||:..|.||..|||:..||.:::..|:....|:.:|:|...:  ..|.::..::..|:||||.
Mouse   584 HGFDNNGRKYDKNGNLDPWWSVESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNG 648

  Fly   583 GIRIAQSAYWKWL-DQVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPY 646
            |:|.|..||.||: |:.:..|...||.:|.:..||||||.|...|:...||.....|:...|.|.
Mouse   649 GLREAFRAYRKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPP 713

  Fly   647 EARVFAMMINSPAFAEAFQCSNSSKMN 673
            :.||...:.|...|.:||.|..:|.||
Mouse   714 QFRVNGAISNFEEFQKAFNCPRNSTMN 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	175/683 (26%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	175/680 (26%)
Phex	NP_035207.1	PepO	67..741	CDD:226118	177/687 (26%)
Phex	NP_035207.1	M13	74..747	CDD:189000	175/680 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920