Protein Alignment Nepl17 and Phex

DIOPT Version :10

• Sequence 1: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_035207.1
• Gene: Phex / 18675
• MGIID: 107489
• Length: 749
• Species: Mus musculus
• Alignment Length: 742
• Identity: 187/742 - (25%)
• Similarity: 317/742 - (42%)
• Gaps: 97/742 - (13%)

  Fly     6 ASACLIFVTLAVGSLAIQGGVFKELTTPLGQQIMRIAKSAEMC-------------SFMDTSVSP 57
            |.|..|..||.:|:|...          :.|.::......|.|             |.::.||.|
Mouse    22 ALALFIGGTLVLGTLLFL----------VSQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVDP 76

  Fly    58 CDDFYGYACGNYATINAATSQKDT-NIRQLMFANYLRRVRQVLNEPRISTDRPMEV--RVKYFYE 119
            |::|:.:||..:.:.|.......: .:...:..|...:::.:| |..:|..|..|.  :.|..|.
Mouse    77 CENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKALL-EKSVSRRRDTEAVQKAKILYS 140

  Fly   120 SCLDTAALRTKQRSHLLSVLREFG-GMPAVEGK-----SWDYVGFDAIEMMAQLLRRYGKLTLLG 178
            ||::..|:.......||.:||... ..|.:|..     .|....|..::.:|....:|.....:.
Mouse   141 SCMNEKAIEKADAKPLLHILRHSPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIR 205

  Fly   179 VYVVPDHFNSQIKRLQLGQ-RLDLAESDEF------ASLWKK--YALKMRLRNLLGLSEELARKT 234
            :||.||...|....|:|.| .|.||..::|      |..::.  |...:....|||.:...|...
Mouse   206 LYVSPDDKASNEHILKLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLLGANSSRAEHD 270

  Fly   235 AEEIIELELELSRSAFDHRMNRDPRLMRHLTMLSNMS------DAYGPILNV--TRFVTSW--LG 289
            .:.::.||::::.....|. ||....|.:...:|.:|      |..|.|..|  ||.....  :|
Mouse   271 MKSVLRLEIKIAEIMIPHE-NRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIG 334

  Fly   290 SEYNLPVFESVPSYLFQVKKILLSTPNHVVANYM--------LSSLLTDFEITANEEQQKVICHE 346
            ...|:.|  .||.|...:.:||.:.....:|||:        :.:|...|:....|..:.:   :
Mouse   335 PSENVVV--RVPQYFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVI---Q 394

  Fly   347 RITELFPDVVDHMVYHSLEQQNPYIANEM----------RSLWVEL----KSSFREMLSSPDIEW 397
            ..|.|.|. .|..| :.:|...||:..:|          :.:..||    :.:|.:||...: ||
Mouse   395 GTTTLLPQ-WDKCV-NFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKEN-EW 456

  Fly   398 LEKQTREELLEKLNGMSFEIAGGQAV----NFEEQFGDLVVSSADYYGNIQRLLEVKARILRTDL 458
            ::..|:.:..||...:..::...:.:    ...|....:..|.:||:||:   |:.:..:.::|.
Mouse   457 MDAGTKRKAQEKARAVLAKVGYPEFIMNDTYVNEDLKAIKFSESDYFGNV---LQTRKYLAQSDF 518

  Fly   459 --LRES--SSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMA 519
              ||::  .:.::.:..|....|...||.:..|...:|..:.|...||.:|.||.:|..:.||..
Mouse   519 FWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFT 583

  Fly   520 HGFDDLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQFSGMLY--GNLRLRRLKSQAESIADNV 582
            ||||:..|.||..|||:..||.:::..|:....|:.:|:|...:  ..|.::..::..|:||||.
Mouse   584 HGFDNNGRKYDKNGNLDPWWSVESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNG 648

  Fly   583 GIRIAQSAYWKWL-DQVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPY 646
            |:|.|..||.||: |:.:..|...||.:|.:..||||||.|...|:...||.....|:...|.|.
Mouse   649 GLREAFRAYRKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPP 713

  Fly   647 EARVFAMMINSPAFAEAFQCSNSSKMN 673
            :.||...:.|...|.:||.|..:|.||
Mouse   714 QFRVNGAISNFEEFQKAFNCPRNSTMN 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	M13	55..678	CDD:341056	175/680 (26%)
Phex	NP_035207.1	M13	74..740	CDD:341056	173/678 (26%)