Protein Alignment Nepl17 and nep-1

DIOPT Version :10

• Sequence 1: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_496490.2
• Gene: nep-1 / 174787
• WormBaseID: WBGene00013926
• Length: 754
• Species: Caenorhabditis elegans
• Alignment Length: 747
• Identity: 176/747 - (23%)
• Similarity: 299/747 - (40%)
• Gaps: 163/747 - (21%)

  Fly    36 QQIMRIAKSAEMCSFMDTSVSPCDDFYGYACGNYATINAATSQKDTNIRQLMFANYLRRVRQVLN 100
            |:..|:.:.:     ::.|:.|||||:.|||  .|.:::.....|..    .::.:.....:||.
 Worm    70 QEASRLLQKS-----LNLSLDPCDDFFEYAC--RAWVDSHPIPDDLT----SYSQFTATREKVLA 123

  Fly   101 EPR--------ISTDRPMEVRVKYFYESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVG 157
            |.|        |.|.:.:.: :|..|.:|:||..........||..::.:|..|.|..:.|....
 Worm   124 EMRKLYEDNTSIPTSKSIAL-IKQIYNTCMDTEKHNAVGARDLLEKIKTYGYWPMVHNEKWREST 187

  Fly   158 FDAIEMMAQLLRRYGKLTLLGVYVVPDHFNSQIKRLQLGQ------------RLDLAESDEFASL 210
            ||..::::..::..............|..|...:.|...|            .||..:.::....
 Worm   188 FDLTKLLSNTIQSRDVSVFFDFGPAEDSRNVSRRLLSFDQGSLGLGYSTRDYYLDEKKYEKQMKA 252

  Fly   211 WKKYAL-KMRLRNL---LGLSEELARKTAEEIIELELELSR--SAFDHRMNRDPRLMRHLTMLSN 269
            ::||.: |:|....   :.::|.......:|||..|.|.::  .|.:.|.|
 Worm   253 YRKYTIGKVRYYTEDAGMAVNESKIESDVDEIIAFEKEWAQILVAEEDRRN-------------- 303

  Fly   270 MSDAYGPILNVTRF------------------VTSWLGSEY---NLPVFESVPSYLFQVKKILLS 313
                |..:.||.||                  .|.:|...|   |..:..|...||.::..:|.:
 Worm   304 ----YTKLYNVRRFDDLKEYMSIIDWKKLTLSTTPFLVHSYLKTNPSIIISDVEYLQKMNTLLQN 364

  Fly   314 TPNHVVANYMLSSLLTDFEITANEEQQKVICHERITELFPDVVDHMVY--HSLEQQNP------- 369
            |...:|.||:|......:.             :.|.:.:.|:.....:  :..:|:.|
 Worm   365 TDPRIVTNYILLRWAGSWS-------------QEIGKKYEDLQQEFAFQMYGRKQRQPRWKDCVS 416

  Fly   370 -------------YI--------ANEMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGM 413
                         |:        .|....:..:|:.:||.|:.:.|  |::.:|::..|||.:.|
 Worm   417 SAGGKLSYASGSMYVRKYFDANAKNTTLDMITDLQEAFRNMMHAND--WMDAETKKYALEKADQM 479

  Fly   414 SFEIA---------------GGQAVNFEEQFGDLVVSSADYYGNI--QRLLEVKARILRTDLLRE 461
            ..:|.               .|.....|:.|..||..|..:..|.  :||||   .:.|.:.:..
 Worm   480 LKQIGYPDFILNDEKLDDWYKGLEGAPEDSFSQLVEKSIQWRNNFYYRRLLE---PVNRFEFISS 541

  Fly   462 SSSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLN 526
            ::.|        ...|....|.:..|...:|..: :|..:|.||.||.:|..:.||:.|||||..
 Worm   542 AAVV--------NAFYSPTRNAIAFPAGILQQPF-FDARFPKALNYGGIGAVIGHEITHGFDDTG 597

  Fly   527 RLYDSRGNLNDNWSTQTKVGFELVKNCLADQFSGM-LYG-NLRLRRLKSQAESIADNVGIRIAQS 589
            |.:|:.|||.|.|...|...|.....|:.:|::.: |.| :||:....:|.|:||||.||:.|..
 Worm   598 RQFDNVGNLRDWWDNTTSSKFNERTQCIIEQYADVKLRGTDLRINGKLTQGENIADNGGIKQAFK 662

  Fly   590 AYWKWLD-----QVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEAR 649
            ||..:|:     :..:.:.|||.:     |||||:..||..|....||.:...:..:.|.|..||
 Worm   663 AYKSYLEKHGGQEARLPQFESLTN-----EQLFFVGYAQVWCGAKTPETKTLLLLTDPHSPETAR 722

  Fly   650 VFAMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681
            |..::.|.|.|||||:|...|.|||..:|:::
 Worm   723 VNTVLTNQPEFAEAFKCPAGSPMNPTKRCVVW 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	M13	55..678	CDD:341056	172/723 (24%)
nep-1	NP_496490.2	M13	85..751	CDD:341056	172/722 (24%)