DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl17 and nep-26

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001022540.1	Gene:	nep-26 / 174593	WormBaseID:	WBGene00014171	Length:	807	Species:	Caenorhabditis elegans

Alignment Length:	795	Identity:	173/795 - (21%)
Similarity:	316/795 - (39%)	Gaps:	178/795 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ASACL--------IFVTLAVGSLAIQGGVFKELTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFY 62
            :..||        :||||   |.||...::.:......::.:..|  :.:...:|.||.|||:||
Worm    72 SKGCLLLTVLVIFLFVTL---SFAIACFLYYQTLPCTSEECVMTA--SRLLKRVDQSVEPCDNFY 131

  Fly    63 GYACGNYATINAATSQKDTNIRQLMFANYLRRVRQVLNEPRIST-------DRPM-----EVRVK 115
            .:|||.:  ||.:.:.|..:      .|.|...::..::..:..       ..|:     |....
Worm   132 QFACGGW--INQSVNLKYDS------WNTLYETQRTAHDQIVQAMHKINDGSYPLPTNAGERAAA 188

  Fly   116 YFYESCLDTAALRTKQRSHLLS-VLREFGG-MPAVEGKSWDYVGFDAIEMMAQLLRR-------- 170
            ..||.|:||..|. :...||.. .:.|.|| ||.::..:.:......||:.....:|
Worm   189 KMYEQCMDTDTLE-QTGLHLWERFVDELGGWMPELKNGALEQEESFEIELDEDEKKRRRFEIEDI 252

  Fly   171 ------YGKLTLLGVYVVPDHFNSQIKRLQLGQRLDLAESDEFASLWKKYALKMRL--------- 220
                  |....|....|..::.||:...:.:.::|.:..:.|      ||.....|
Worm   253 ILSAFNYSVFPLFWAGVEVNYLNSKEHLITIYEQLPILLAPE------KYHYNKELTPEMIYGKM 311

  Fly   221 ------RNLLGLSEELAR-----KTAEEI---------IELELELSRSAFDHRMNRDPRLMRHLT 265
                  |.|..:.|||:.     .|.|::         :|.::.::.|.| ::..::    |:..
Worm   312 EGPPVTRALQQVGEELSAVLGFDSTDEKVRMMIANMIYLEYQITMAGSTF-YKEKKE----RYTV 371

  Fly   266 MLSNMSDAYGPILNVTRFVTSWLGSEYN-------------LPVFESVPSYLFQVKKILLSTPNH 317
            ::........|.:|...|::..:|...:             :|:..::...|.|.:..:....|:
Worm   372 VMLRELQEIAPAINWHYFLSRLVGENLSHSEPIALKTGTQWIPILSAIVEKLKQSRSGVAVLKNY 436

  Fly   318 VVAN------------------YMLSSLLTDFEITANEEQQKVICHERITELFP----------D 354
            |...                  :|..||     .:....|:|..|..|::.:||          |
Worm   437 VKWKTIMFHLAYASPKCRDGLLWMAVSL-----YSGAASQRKEFCVLRLSGIFPLSLPSILRKID 496

  Fly   355 VVDHMVYHSLEQQNPYIANEMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGMSFEIAG 419
            .:||...:....||  ||:       .::..:.||:.|.:: :.:::|||.:::|:|.|:..|..
Worm   497 GIDHTEKNVKAVQN--IAD-------RIQEKYEEMVRSSNL-FSDRETRENVIDKVNNMTKFIGF 551

  Fly   420 GQAVNFEEQ------------FGDLVVSSADYYGNIQRLLEVKARILRTDLLRESSSVYYYHGVT 472
            ..|:..:.:            |..:|:.|:..|         |.|:.|..|..:..|........
Worm   552 PDAMRSDYEMEKEAVRLHDTLFWSMVLGSSSVY---------KERLQRLRLPVDPRSWVDTRPAI 607

  Fly   473 ATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRGNLND 537
            :.|.:..|.|||.:|...::..|. |:.......|..:|..:.||:.|.||...:|:...|||..
Worm   608 SVPAHNYERNLVQIPFDSLRLPYA-DEHQLDFANYAGIGTIIGHELTHAFDGQGKLHGPTGNLGV 671

  Fly   538 NWSTQTKVGFELVKNCLADQFSGMLYGNLRLRRLKSQAESIADNVGIRIAQSAYWKWLDQVEMEE 602
            .|||.:...|:..:.|...|::|::..:......:...|:|||.||:::|..| ||   ....:.
Worm   672 WWSTDSIREFKAREQCFVKQYAGLMDSHDMNAAKEGLYENIADQVGLKVAYEA-WK---SNGNQN 732

  Fly   603 TESLPHMTQ-SPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAMMINSPAFAEAFQC 666
            :..:|.:.: |.:|||||:..|..|:     .|:...:...|.....|:...:.|||.||.|::|
Worm   733 SGRMPGLEKYSQDQLFFLAYTQGWCA-----LRSKSYKLQPHMEERIRMLGSLQNSPEFASAWKC 792

  Fly   667 SNSSKMNPPNKCLMY 681
            |:.|.||||:||.::
Worm   793 SSESFMNPPDKCSIW 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	157/733 (21%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	159/733 (22%)
nep-26	NP_001022540.1	PepO	111..807	CDD:226118	164/751 (22%)
nep-26	NP_001022540.1	M13	124..805	CDD:189000	160/734 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020