DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl17 and nep-5

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001364754.1	Gene:	nep-5 / 173933	WormBaseID:	WBGene00017393	Length:	694	Species:	Caenorhabditis elegans

Alignment Length:	706	Identity:	152/706 - (21%)
Similarity:	288/706 - (40%)	Gaps:	124/706 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIFVTLAVGSLAIQG-GVFKELTTPLGQQIMRI------------AKSAEMCSFMDTSVSPCDDF 61
            |:.:..|:|:|.:.. ..||  ..|..|:.:||            ..|||:...||:||:||::|
Worm    72 LVLLIFALGALGLHDISAFK--WEPKPQKALRIMLDLPCQTKECVKYSAELLELMDSSVNPCENF 134

  Fly    62 YGYACGNYATINAATSQKDTNIRQLMFANYLRRVRQVLNEPRISTDRPMEVRVKYFYESCLDTAA 126
            :.:.|..:            |.|:..|    .|:.:::|.......|.....|:.....|.....
Worm   135 HHHVCNGF------------NPRKKDF----ERLMKLINIQEKPDHRKAVNVVRRMLSKCAMGKT 183

  Fly   127 LRTKQRSHLLSVLREFGGMP-AVEGKSWDYVGFDAIEMMAQLLRRYGKLTLLGVYVV---PD--- 184
            ....|...|.|::  ..|:| .:...||...........:.....|..||.:..:::   ||
Worm   184 EEIHQVGRLSSII--LPGLPFPLLNNSWTKPSDPISTSNSSTTYSYPFLTKILAHIILHNPDDAG 246

  Fly   185 ------HFNSQIKRLQLGQRLDLAESDEFASLW---KKYALKMRLRNLLGLSEELARKTAEEIIE 240
                  ..:|:.....:.....:..:.:|.:::   |:.|.:.....::.|..:..|: ..::|:
Worm   247 FVGIKPSSDSEFSLFVVKPFSPVLTNFKFRNMYDILKRNAPESSTNGMIDLEFDRQRQ-LNDVIK 310

  Fly   241 LELELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLGSEY---NLPVFESVPS 302
            |:.:|.:..|    ..||.:: :||.:....    ||::..|.:.||:.:.|   ...|:....|
Worm   311 LQTKLEKIEF----KADPEVV-NLTEIQRQM----PIIDWKRLIDSWIPNGYAHLKEKVYGFNTS 366

  Fly   303 YLFQVKKILLSTPNHVVANYMLSSLLTDFEITANEEQQKVICHERITELFPDVVDHMVYHSLEQQ 367
            |..::..|:.|||:..:.|::.......|..|......:..|..:::...|..:  ::|.|   :
Worm   367 YYEEINAIISSTPSETIYNFLFLRFSFKFLRTEVASDLEDTCLHQLSTTIPGKI--VLYGS---E 426

  Fly   368 NPYIANEMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGMS--FEIAGGQAVNFEEQFG 430
            .|...|.:..:...:|...:..|::  ::|::.:..||..:|.|...  |...|...:  :|..|
Worm   427 EPEALNLLNGMLHTIKDQLKRSLAT--LKWMDSRGIEEAQKKFNKTKTVFGFTGEDLI--DELVG 487

  Fly   431 DLVVSSADYYGNIQRLLEVKARILRTDLLRESSSVYYYHGVTATPIYETETNLVVLPVSYMQHRY 495
            .:...| :|...:|.:|..:.|.:...:...:.:|:    :.:...|..|.|.:.:..:.:.:.:
Worm   488 KITPES-NYISTLQNVLLWQTRNMFKSVAENNVTVF----LNSEVFYSVEKNEITISRALLHYPF 547

  Fly   496 LWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQFSG 560
            :..:: |....:.|:...:..:|.|.||:..|.|||.||..:.|:|:|:..|:::..|    |.|
Worm   548 MSANL-PNYTNFATIASKILPQMIHIFDERGRFYDSDGNHRNWWNTETERYFQIIVQC----FDG 607

  Fly   561 MLYGNLRLRRLKSQAESIADNV-GIRIAQSAYWKWLDQVEMEETESLPHMTQ-SPEQLFFLSAAQ 623
            |:                 .|| |:.:  |..|...|..: |...:||.:.| |.|.|||.|..:
Worm   608 MM-----------------QNVFGVSV--SIGWNAYDSTK-EPYATLPGIQQSSDEALFFYSMVK 652

  Fly   624 FMC-SDIYPERRANFVRNNFHPPYEARVFAMMINSPAFAEAFQCSNSSKMNPPNKC 678
            .|| ||  |:                .|...:.:.|.|..||:|:|.:|||||.||
Worm   653 TMCTSD--PD----------------NVNEALASVPQFNSAFKCNNGTKMNPPTKC 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	132/646 (20%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	134/646 (21%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:417498	136/648 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166979
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28686
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.820