Protein Alignment Nepl17 and nep-12

DIOPT Version :10

• Sequence 1: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001364537.1
• Gene: nep-12 / 173824
• WormBaseID: WBGene00017842
• Length: 832
• Species: Caenorhabditis elegans
• Alignment Length: 732
• Identity: 175/732 - (23%)
• Similarity: 310/732 - (42%)
• Gaps: 129/732 - (17%)

  Fly    31 TTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFYGYACGNYATINA-ATSQKDTNIRQLMFANYLRR 94
            :|.|..:.:|:|  |...:.|:...:||:|||.:|||.|||... |..:|...:...|.....|.
 Worm   149 STCLTPECIRLA--ASYLNNMNRDANPCEDFYEFACGKYATRKVIAEHEKKVTVLSEMKKEMDRH 211

  Fly    95 VRQVLNE-PRISTDRPMEVRVKYFYESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVGF 158
            ::.:|.: .|.:|.|.|::...|| :||:|..:........|:|::...||.|.:....:|.:.|
 Worm   212 LKDILEKTSRENTTRSMKLAQIYF-DSCMDEFSQDDLGVQPLMSMISNLGGWPLLTNARFDSIDF 275

  Fly   159 DAIEMMAQLLRRYGKLTLLGVYVVPDHFNSQIK--------RLQLGQR---LDLAESDEFASLWK 212
            . .|::|..|..||...:..|: |...|:...|        :|.|.::   .::..|:.:...::
 Worm   276 Q-WEVLAGHLALYGVDGIFRVF-VHSSFDDSDKNVLMFSPPKLFLEKKKFYREVPSSNVYLQYYR 338

  Fly   213 KYALKMRLRNLLGLSEE----LARKTAEEIIELE--------LELSRS---------------AF 250
            :|.|.  |.:|||:..|    :.....::||:.|        :||||:               .:
 Worm   339 QYILS--LLSLLGVDMEDETGVIEYQVDDIIDFERRIANLTRIELSRNHSSINNMITFGEFKRKY 401

  Fly   251 DHRMNRDPRLMRHLT-MLSNMSDAYGPILNVTRFVTSWLGSEYNLPVFESVPSYLFQVKKILLST 314
            | ::|.|......:. .|..|.|:.  ::||...                  :|...:..::.|.
 Worm   402 D-KINWDAFFNEEMRGNLGRMPDSL--VINVVDV------------------NYFDNLYSLIKSK 445

  Fly   315 PNHVVANYMLSSLLTDFEI-------------------TANEEQQKVICHERITE-LFPDVVDHM 359
            |...:.|:::..|::::::                   .::::....:|...:.| |...:....
 Worm   446 PLSSINNFLMWCLVSNYDMYLPAKYRKPMLDFRQKMYGVSSDDPLWEVCVGEVRENLAMPLSTEY 510

  Fly   360 VYHSLEQQNPYIANEMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGMSFEIAGGQAVN 424
            ......:::..:|.:|..   :||.:..:.|.:.|  |:::.|||..|.||:.|      |..:.
 Worm   511 AQKFFTKKDKLVAEDMIR---DLKKAMEQTLLNAD--WIDESTREAALMKLDAM------GHKIG 564

  Fly   425 FEEQ----------FGDLVVSSADYYGNIQRLLEVKARILRTDLLRESSSVYYYHGVTATPIYET 479
            |.:.          :..:.:::..|:.|...|.:...|...:.|.|..|.:.:...:.|...:..
 Worm   565 FPDSLLNETAVLLPYAGVRLTANQYFDNAISLKKAAYRDALSKLHRTPSLIDWASPIIAVDAFHY 629

  Fly   480 ET-NLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLYDSRGNLNDNWSTQT 543
            .| |.::.|...:|......|. ||...||.:|..:.||:.||:|||...||.:|||...|.|:|
 Worm   630 FTGNEIIFPAGILQFPMFVPDA-PAFSNYGAIGMGIGHEITHGYDDLGAQYDDKGNLRGWWHTET 693

  Fly   544 KVGFELVKNCLADQFSGMLY--------GNLRLRRLKSQAESIADNVGIRIAQSAYWKWLDQVEM 600
            ...|:..|.|...|:...:.        |.:.:      .|:||||.|:|:|..||....|:  .
 Worm   694 MTTFQKKKQCFVAQYGSKIEPQTGRKVDGKMTI------GENIADNGGLRVAFQAYQLRSDR--E 750

  Fly   601 EETESLPHMTQ-SPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAMMINSPAFAEAF 664
            :||..||.:|. ||.|||||:.|...|..:.|....:.:..:.|.....||...:.|.|||::.|
 Worm   751 KETRRLPGLTDFSPNQLFFLAYANTWCEALKPSAIDHIMDTDVHSLGMFRVNVPLQNLPAFSKEF 815

  Fly   665 QCSNSSKMNPPNKCLMY 681
            .|...|.|||..||.::
 Worm   816 DCPIGSPMNPFEKCRIW 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	M13	55..678	CDD:341056	167/703 (24%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	168/704 (24%)