Protein Alignment Nepl17 and Mme

DIOPT Version :10

• Sequence 1: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_032630.2
• Gene: Mme / 17380
• MGIID: 97004
• Length: 750
• Species: Mus musculus
• Alignment Length: 762
• Identity: 190/762 - (24%)
• Similarity: 321/762 - (42%)
• Gaps: 137/762 - (17%)

  Fly    10 LIFVTLAVGSLAI----QGGVFKELTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFYGYACGNYA 70
            |:...:||..:|:    ..|:.|....        |..:|.:...||.||.||.||:.||||.:.
Mouse    36 LLLTIIAVTMIALYATYDDGICKSSDC--------IKSAARLIQNMDASVEPCTDFFKYACGGWL 92

  Fly    71 TINA--ATSQKDTNIRQLMFANYLRR-----VRQVLNEPRISTDRPMEVRVKYFYESCLDTAALR 128
            ..|.  .||.:.:|.      :.||.     ::.||.||: :.|.....:.|..|.||::.:|:.
Mouse    93 KRNVIPETSSRYSNF------DILRDELEVILKDVLQEPK-TEDIVAVQKAKTLYRSCINESAID 150

  Fly   129 TKQRSHLLSVLREFGGMPAVEGKSWDY---VGFDAIEMMAQLLRRYGKLTLLGVYVVPDHFNSQI 190
            ::....||.:|.:..|.| |...:||.   ..:.|.:.:|||..:|||..|:..:|..|..||..
Mouse   151 SRGGQPLLKLLPDIYGWP-VASDNWDQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQ 214

  Fly   191 KRLQLGQ-RLDLAESD--EFASLWKK-----------YALKMRLRNLLGLSEELARKTAEEIIEL 241
            ..:...| ||.|...|  |...::|:           .|..:|....|.:.|........:::||
Mouse   215 HIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQSLPIDENQLSLEMNKVMEL 279

  Fly   242 ELELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLGSEYNLPVFESV------ 300
            |.|::.:........||.|:.:...|:.:.:.:...:|...|  ||  |.:...:..:|
Mouse   280 EKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEVNGKSF--SW--SNFTNEIMSTVNINIQN 340

  Fly   301 --------PSYLFQVKKILLSTPNHVVANYM--------LSSLLTDFEITANEEQQKVI------ 343
                    |.||.::|.||.......:.|.|        :|||..:::.:.|..::.:.
Mouse   341 EEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSET 405

  Fly   344 -----CHERITELFPDVVDHMVYHSLEQQNPYIANEMRSLWVELKSSFREML--SSPDIEWLEKQ 401
                 |...:.....:.|..:...:.      .|.|.:.:..:|.:..||:.  :..|:.|::.:
Mouse   406 ATWRRCANYVNGNMENAVGRLYVEAA------FAGESKHVVEDLIAQIREVFIQTLDDLTWMDAE 464

  Fly   402 TREELLEKLNGMSFEIAGGQAVNFEEQFG--DLVVSSA---------------DYYGN-IQRLLE 448
            |:::..||            |:..:|:.|  |.::|:.               :|:.| ||.|..
Mouse   465 TKKKAEEK------------ALAIKERIGYPDDIISNENKLNNEYLELNYREDEYFENIIQNLKF 517

  Fly   449 VKARILRTDLLRE--SSSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPA----ALKY 507
            .:::.|:.  |||  ....:..........|.:..|.:|.|...:|..:     :.|    :|.|
Mouse   518 SQSKQLKK--LREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPF-----FSAQQSNSLNY 575

  Fly   508 GTLGFTMAHEMAHGFDDLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQ---FSGMLYGNLRLR 569
            |.:|..:.||:.|||||..|.::..|:|.|.|:.|:...|:....|:..|   ||..|.|...|.
Mouse   576 GGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFSWDLAGGQHLN 640

  Fly   570 RLKSQAESIADNVGIRIAQSAYWKWLDQVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERR 634
            .:.:..|:||||.||..|..||..::.  :..|.:.||.:..:.:|||||:.||..|....||..
Mouse   641 GINTLGENIADNGGIGQAYRAYQNYVK--KNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYA 703

  Fly   635 ANFVRNNFHPPYEARVFAMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681
            .|.::.:.|.|...|:...:.||..||:||.|..:|.|||..||.::
Mouse   704 VNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	M13	55..678	CDD:341056	177/708 (25%)
Mme	NP_032630.2	Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	77..748	CDD:341056	178/709 (25%)