DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl17 and Mme

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001276391.1	Gene:	Mme / 17380	MGIID:	97004	Length:	750	Species:	Mus musculus

Alignment Length:	762	Identity:	190/762 - (24%)
Similarity:	321/762 - (42%)	Gaps:	137/762 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIFVTLAVGSLAI----QGGVFKELTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFYGYACGNYA 70
            |:...:||..:|:    ..|:.|....        |..:|.:...||.||.||.||:.||||.:.
Mouse    36 LLLTIIAVTMIALYATYDDGICKSSDC--------IKSAARLIQNMDASVEPCTDFFKYACGGWL 92

  Fly    71 TINA--ATSQKDTNIRQLMFANYLRR-----VRQVLNEPRISTDRPMEVRVKYFYESCLDTAALR 128
            ..|.  .||.:.:|.      :.||.     ::.||.||: :.|.....:.|..|.||::.:|:.
Mouse    93 KRNVIPETSSRYSNF------DILRDELEVILKDVLQEPK-TEDIVAVQKAKTLYRSCINESAID 150

  Fly   129 TKQRSHLLSVLREFGGMPAVEGKSWDY---VGFDAIEMMAQLLRRYGKLTLLGVYVVPDHFNSQI 190
            ::....||.:|.:..|.| |...:||.   ..:.|.:.:|||..:|||..|:..:|..|..||..
Mouse   151 SRGGQPLLKLLPDIYGWP-VASDNWDQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQ 214

  Fly   191 KRLQLGQ-RLDLAESD--EFASLWKK-----------YALKMRLRNLLGLSEELARKTAEEIIEL 241
            ..:...| ||.|...|  |...::|:           .|..:|....|.:.|........:::||
Mouse   215 HIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQSLPIDENQLSLEMNKVMEL 279

  Fly   242 ELELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLGSEYNLPVFESV------ 300
            |.|::.:........||.|:.:...|:.:.:.:...:|...|  ||  |.:...:..:|
Mouse   280 EKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEVNGKSF--SW--SNFTNEIMSTVNINIQN 340

  Fly   301 --------PSYLFQVKKILLSTPNHVVANYM--------LSSLLTDFEITANEEQQKVI------ 343
                    |.||.::|.||.......:.|.|        :|||..:::.:.|..::.:.
Mouse   341 EEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSET 405

  Fly   344 -----CHERITELFPDVVDHMVYHSLEQQNPYIANEMRSLWVELKSSFREML--SSPDIEWLEKQ 401
                 |...:.....:.|..:...:.      .|.|.:.:..:|.:..||:.  :..|:.|::.:
Mouse   406 ATWRRCANYVNGNMENAVGRLYVEAA------FAGESKHVVEDLIAQIREVFIQTLDDLTWMDAE 464

  Fly   402 TREELLEKLNGMSFEIAGGQAVNFEEQFG--DLVVSSA---------------DYYGN-IQRLLE 448
            |:::..||            |:..:|:.|  |.::|:.               :|:.| ||.|..
Mouse   465 TKKKAEEK------------ALAIKERIGYPDDIISNENKLNNEYLELNYREDEYFENIIQNLKF 517

  Fly   449 VKARILRTDLLRE--SSSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPA----ALKY 507
            .:::.|:.  |||  ....:..........|.:..|.:|.|...:|..:     :.|    :|.|
Mouse   518 SQSKQLKK--LREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPF-----FSAQQSNSLNY 575

  Fly   508 GTLGFTMAHEMAHGFDDLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQ---FSGMLYGNLRLR 569
            |.:|..:.||:.|||||..|.::..|:|.|.|:.|:...|:....|:..|   ||..|.|...|.
Mouse   576 GGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFSWDLAGGQHLN 640

  Fly   570 RLKSQAESIADNVGIRIAQSAYWKWLDQVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERR 634
            .:.:..|:||||.||..|..||..::.  :..|.:.||.:..:.:|||||:.||..|....||..
Mouse   641 GINTLGENIADNGGIGQAYRAYQNYVK--KNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYA 703

  Fly   635 ANFVRNNFHPPYEARVFAMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681
            .|.::.:.|.|...|:...:.||..||:||.|..:|.|||..||.::
Mouse   704 VNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	177/708 (25%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	177/708 (25%)
Mme	NP_001276391.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_001276391.1	M13	77..748	CDD:341056	178/709 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920