DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl17 and nep-11

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_494538.1	Gene:	nep-11 / 173685	WormBaseID:	WBGene00017557	Length:	848	Species:	Caenorhabditis elegans

Alignment Length:	745	Identity:	184/745 - (24%)
Similarity:	309/745 - (41%)	Gaps:	158/745 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KSAEMCS-------------FMDTSVSPCDDFYGYACGNYATINAATSQKDTNIRQLMFANYLRR 94
            |..|:||             .|:|||.|||||:.:|||.:   |......|.......||....:
Worm   156 KEPEVCSTPGCVRAATHFLNAMNTSVDPCDDFFEFACGQW---NDQHPIPDDMYGFGTFAYAREQ 217

  Fly    95 VRQ---VLNEPRISTDRPMEVRVKYFYESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYV 156
            |||   ||.|..:.|:.......:..|.||::...|.......|...|.|.|..|.:: ::||..
Worm   218 VRQQLRVLLEQEVVTESESINMARATYRSCMNKTQLDELMTGPLFETLTELGEWPLLQ-ENWDKT 281

  Fly   157 GFDAIEMMAQLLRRYGKLTLLGVYVVPDHFNSQIKRLQLGQR------------LDLAESDEFAS 209
            .|:...::....|.||......:|:..|..|:....|.:.|.            |:........:
Worm   282 KFNFTSLLVNSRRDYGVDVFFQLYIYADSKNTSRNTLFIDQSTLALGRGTRDYYLNTTLFSSHMT 346

  Fly   210 LWKKYALKMRLRNLLGLSEELARKTA------EEIIELELELSR--SAFDHRMNRDPRLMRHLTM 266
            .::||.  .::.:||.....|.|..:      |:||:.|:||::  .|.|.|.|.        |.
Worm   347 AYRKYL--RQIAHLLKTDGNLTRSESEMNADIEKIIDFEIELAKIIVAEDERRNN--------TR 401

  Fly   267 LSN---MSDAYGPILNVTRFVTSWLGSEYNLPVFESV-PS------------------YLFQVKK 309
            |.|   :.|.|..:..|     .|      :|.|:|: ||                  ||..|.:
Worm   402 LYNKRQIQDLYNLLPQV-----DW------VPFFQSIAPSDLTHLFHNETEIIICEIEYLQHVSE 455

  Fly   310 ILLSTPNHVVANYMLSSLLTDFEITANEEQQKVICHERITELFPDV-VDHMVYHSLEQQNP---- 369
            ::..|...::.||:|..::          |..|   ..:.|.|.|: .|.:...:.:||:|
Worm   456 LIEKTDVGLLTNYVLWRVV----------QSNV---RYLDERFEDIKQDFLKVMTGQQQSPPRWK 507

  Fly   370 -----------------YI--------ANEMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEK 409
                             |:        .:|...:.:.|::||.:::...|  |::::|:...:||
Worm   508 DCAQVPSTVLPLAAGAIYVQAHFQESDKHEALRMIMHLRNSFADLVRQND--WMDEETKAVAIEK 570

  Fly   410 LNGMSFEIAGGQAVN----FEEQFGDLVVSSADYYGNIQRLLEVKARI-LRTDLLRESSSVYYYH 469
            .|.|...|......|    .::|:..|.:|.:|.|..|.:    |:.: :::...::.:..:..|
Worm   571 ANSMINNIGYPDVTNDLPKLDKQYLGLSISDSDTYYYIMK----KSVVWMQSREFQKLTKPFDKH 631

  Fly   470 GVTATP-----IYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLY 529
            ....:|     .|..|.|.:..|...:|..: :...:|.|:.||.:|..:.||:.|||||....|
Worm   632 EFDISPAVVNAFYSPEKNAITFPAGILQPPF-FSGTFPKAVNYGAIGAVIGHEITHGFDDQGSQY 695

  Fly   530 DSRGNLNDNWSTQTKVGFELVKNCLADQFSGMLYG-------NLRLRRLKSQAESIADNVGIRIA 587
            |..|||::.||..:...|:..:.|:.:|     ||       |.|:....:|.|:||||.|::.|
Worm   696 DKDGNLHNWWSESSLNSFDTRRRCIVEQ-----YGNYTVPKTNFRVNGKLTQGENIADNGGVKEA 755

  Fly   588 QSAYWKWLDQVEMEETESLPHMTQ-SPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVF 651
            ..||.|::  .|..|...||.:.| :.||:||:|.|.|.|...........|..:.|.|...||.
Worm   756 FQAYQKYV--TENGEEPRLPGLQQYTNEQIFFVSYAHFWCGKKKEAAAMQQVLTDEHSPEVFRVI 818

  Fly   652 AMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681
            .::.|..|||:.::|..::.:||.:||:::
Worm   819 GVLSNMQAFADVYKCPRNAPVNPDHKCIVW 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	177/728 (24%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	175/715 (24%)
nep-11	NP_494538.1	PepO	174..848	CDD:226118	180/725 (25%)
nep-11	NP_494538.1	M13	181..845	CDD:189000	175/715 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020