Protein Alignment Nepl17 and nep-10

DIOPT Version :10

• Sequence 1: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_494532.2
• Gene: nep-10 / 173684
• WormBaseID: WBGene00017555
• Length: 711
• Species: Caenorhabditis elegans
• Alignment Length: 723
• Identity: 152/723 - (21%)
• Similarity: 286/723 - (39%)
• Gaps: 176/723 - (24%)

  Fly    41 IAKSAEMCSFMDTSVSPCDDFYGYACGNYATINAATSQKDTNIRQLMFANYLRRVRQVLNEPRIS 105
            |..:.|:.::.|.||.||.|||.:.||.:...:|....:....|..:    .:.:|:.|.:.:.|
 Worm    83 ITLAHELHNYKDPSVDPCQDFYQHFCGKFYEHSAIGQGRMATKRSTL----SKLIREFLLKNKTS 143

  Fly   106 TDRPMEVRVKYFYESC------LDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVGFDAIEMM 164
            |.: .|..:|..|..|      .|..::..:....:.|.:::.|..|.:: |.||...|:..||:
 Worm   144 TSK-SENTMKQVYAKCRELQKISDLNSIPPQALLDIFSDIKKIGAWPVLD-KDWDGSKFNLNEML 206

  Fly   165 AQLLRRYGKLTLLGVYVVPDHFN--------------------------------SQIKRLQLGQ 197
            .||: ..|: |.||.:    ||:                                ::|| :..|.
 Worm   207 RQLV-NLGE-THLGFF----HFDFIARPYVLIKPPLKQGVQKSVLEKVVKMILEANEIK-MDQGF 264

  Fly   198 RLDLAESDEFASLWKKYALKMRLRNLLGLSEELARKTAEEIIELELELSRSAFDHRMNRDPRLMR 262
            ..||.|..|.::..|...|....|:::||..::.|.....:| ||: :.||    :|||
 Worm   265 SEDLDEYFELSNRIKIDKLPRTSRSIVGLLPDVRRINFRGLI-LEM-MPRS----KMNR------ 317

  Fly   263 HLTMLSNMSDAYGPILNVTRFVTSWLGSEYNLPVFESVPSY---LF-------QVKKILLSTPNH 317
                                    :||:     :|:.|.:|   ||       .:..|:.||.|.
 Worm   318 ------------------------FLGT-----LFQKVVTYHHPLFVRDNETNHLDTIIRSTSNR 353

  Fly   318 VVANYMLSSLL------TDFEITANEEQ-QKVICHERITELFPDVVDHMVYHSLEQQNPYIANEM 375
            .:|||::.:.:      ..|.:.::.|: :|::    :.||....:...:.:.:::.|   ..|:
 Worm   354 ALANYLIFNFIHSSIKFLTFGLKSDRERCEKIV----VQELPRPSLRVFMRNCVDKGN---REEV 411

  Fly   376 RSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGMS--------FEIAGGQAVNFEEQFGDL 432
            ..|...:|.:..||:...|.  .....::.:|:|:..:.        |:..|    ..::::.:|
 Worm   412 AKLTETVKENVLEMIRESDS--FTPSVKKRVLKKVEAIGAIIGYPDHFDPPG----TLDKEYENL 470

  Fly   433 VVSSAD-YYGNIQRLLEVKARILRTDLLRESSSVYYYHGVTATPI------------YETETNLV 484
            .:.::| ||...|:|.:          ||....:.:..|  .||:            |:::.|.:
 Worm   471 TLDASDSYYKMSQKLHQ----------LRLQHQMEFLAG--QTPLSPSDQVLEVNAHYDSKDNAL 523

  Fly   485 VLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDD--LNRLYDSRGNLNDNW-STQTKVG 546
            .:...::...: :|..||..:.....||.:.||..|..|.  |.|         |.| .|:....
 Worm   524 TVLAPFLDDPF-FDSTYPEYVNLIFTGFLIGHEFGHSIDPKILRR---------DGWYKTEDMTE 578

  Fly   547 FELVKNCLADQFSGMLYGNLRLRRLKSQAESIADNVGIRIAQSAYWKWLDQVEMEETESL-PHMT 610
            :.....||.||:..  |.:....:..:....|.:.||..:.:...|:...::::.:.:.| ....
 Worm   579 YGKRAQCLIDQYDN--YDDPDHGKQMNGTYCIGEIVGDWVGRDVTWRAFKKMDLSKMQKLIGFED 641

  Fly   611 QSPEQLFFLSAAQFMCSDIYPERRANF--VRNNFHPPYEARVFAMMINSPAFAEAFQCSNSSKMN 673
            ::.:||:|...:.|.|.   |....:.  :.::.||....||..:..|.|.||:||.|...|.||
 Worm   642 KNLDQLYFRIQSLFFCG---PRSMKSLEQLLSDPHPTEVFRVNGIYSNMPQFAKAFNCPIGSPMN 703

  Fly   674 PPNKCLMY 681
            |..||.|:
 Worm   704 PEKKCKMF 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	M13	55..678	CDD:341056	145/704 (21%)
nep-10	NP_494532.2	M13	97..709	CDD:341056	146/705 (21%)